Methyl 2-broMo-4-fluoro-6-Methylbenzoate
- Product Name
- Methyl 2-broMo-4-fluoro-6-Methylbenzoate
- CAS No.
- 1262396-04-2
- Chemical Name
- Methyl 2-broMo-4-fluoro-6-Methylbenzoate
- Synonyms
- Methyl 2-broMo-4-fluoro-6-Methylbenzoate;2-bromo-4-fluoro-6-methylbenzoic acid methyl ester;Benzoic acid, 2-bromo-4-fluoro-6-methyl-, methyl ester
- CBNumber
- CB12668803
- Molecular Formula
- C9H8BrFO2
- Formula Weight
- 247.06
- MOL File
- 1262396-04-2.mol
Methyl 2-broMo-4-fluoro-6-Methylbenzoate Property
- Boiling point:
- 255.6±35.0 °C(Predicted)
- Density
- 1.506±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M221870
- Product name
- Methyl2-Bromo-4-Fluoro-6-Methylbenzoate
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- CS-0061258
- Product name
- Methyl2-bromo-4-fluoro-6-methylbenzoate
- Packaging
- 100mg
- Price
- $68
- Updated
- 2021/12/16
- Product number
- CS-0061258
- Product name
- Methyl2-bromo-4-fluoro-6-methylbenzoate
- Packaging
- 250mg
- Price
- $103
- Updated
- 2021/12/16
- Product number
- CS-0061258
- Product name
- Methyl2-bromo-4-fluoro-6-methylbenzoate
- Packaging
- 1g
- Price
- $258
- Updated
- 2021/12/16
- Product number
- CS-0061258
- Product name
- Methyl2-bromo-4-fluoro-6-methylbenzoate
- Packaging
- 5g
- Price
- $775
- Updated
- 2021/12/16
Methyl 2-broMo-4-fluoro-6-Methylbenzoate Chemical Properties,Usage,Production
Synthesis
1003709-47-4
74-88-4
1262396-04-2
The general procedure for the synthesis of methyl 2-bromo-4-fluoro-6-methylbenzoate from 2-bromo-4-fluoro-6-methylbenzoic acid and iodomethane was as follows: 2-bromo-4-fluoro-6-methylbenzoic acid (1.94 g, 8.33 mmol), anhydrous potassium carbonate (1.72 g, 12.5 mmol), and iodomethane (2.36 g, 17 mmol) were mixed in N,N- dimethylformamide (15 mL) at 20°C with vigorous stirring for 23 hours. After completion of the reaction, the suspension was poured into 70 mL of water for liquid-liquid separation. The product was extracted with ethyl acetate (4 × 25 mL), and the combined organic phases were washed sequentially with water (5 × 20 mL) and brine (2 × 20 mL). The organic phase was dried over anhydrous sodium sulfate, filtered and concentrated to give 2.07 g (100% yield) of methyl 2-bromo-4-fluoro-6-methylbenzoate. The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 7.18 (dd, 3JH-F = 8.1 Hz, 4JH-H = 2.4 Hz, 1H, Ar), 6.91 (dd, 3JH-F = 9.0 Hz, 4JH-H = 2.2 Hz, 1H, Ar), 3.96 (s, 3H, OCH3), 2.35 (s. 3H, CH3).
References
[1] Patent: WO2011/6803, 2011, A1. Location in patent: Page/Page column 35-36
[2] Patent: WO2014/64149, 2014, A1. Location in patent: Page/Page column 27; 28
Methyl 2-broMo-4-fluoro-6-Methylbenzoate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl 2-broMo-4-fluoro-6-Methylbenzoate manufacturers
- Product
- Methyl 2-broMo-4-fluoro-6-Methylbenzoate 1262396-04-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 97%
- Supply Ability
- 100kg
- Release date
- 2020-02-01