6-BroMo-1-Methyl-1H-benzo[d][1,2,3]triazole

6-BroMo-1-Methyl-1H-benzo[d][1,2,3]triazole Property

Boiling point:

332.6±15.0 °C(Predicted)

Density 

1.76±0.1 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

0.36±0.30(Predicted)

Appearance

Off-white to light brown Solid

Safety

HS Code 

2933998090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

6-BroMo-1-Methyl-1H-benzo[d][1,2,3]triazole Chemical Properties,Usage,Production

Synthesis

Example 2003: Compound 2003A (400 mg, 2.0 mmol) was dissolved in 10 mL of tetrahydrofuran (THF) and sodium methanolate (4 mL, 2.0 mmol) was added and reacted for 30 minutes. Subsequently, iodomethane (0.5 mL, 8.0 mmol) was added and the reaction mixture was stirred for 4 hours at room temperature. After completion of the reaction, the mixture was poured into a mixture of ethyl acetate and water. The aqueous layer was extracted twice with ethyl acetate, all organic layers were combined, washed with saturated brine solution and dried with anhydrous sodium sulfate. The solvent was removed by rotary evaporator and the product was purified by silica gel column chromatography to afford compounds 2003B (105 mg, 25% yield), 2003C (110 mg, 26% yield) and 2003D (106 mg, 25% yield), respectively.

References

[1] Patent: WO2007/84451, 2007, A1. Location in patent: Page/Page column 167