2,4(1H,3H)-Quinazolinedione, 5-Methoxy-
- Product Name
- 2,4(1H,3H)-Quinazolinedione, 5-Methoxy-
- CAS No.
- 61948-86-5
- Chemical Name
- 2,4(1H,3H)-Quinazolinedione, 5-Methoxy-
- Synonyms
- 5-Methoxy-1H-quinazoline-2,4-dione;5-Methoxyquinazoline-2,4(1H,3H)-dione;2,4(1H,3H)-Quinazolinedione, 5-Methoxy-;5-Methoxy-1,2,3,4-tetrahydroquinazoline-2,4-dione
- CBNumber
- CB12676660
- Molecular Formula
- C9H8N2O3
- Formula Weight
- 192.17
- MOL File
- 61948-86-5.mol
2,4(1H,3H)-Quinazolinedione, 5-Methoxy- Property
- storage temp.
- Inert atmosphere,Room Temperature
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M342538
- Product name
- 5-Methoxyquinazoline-2,4(1H,3H)-dione
- Packaging
- 100mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- A102345
- Product name
- 5-Methoxyquinazoline-2,4(1H,3H)-dione
- Purity
- 98%
- Packaging
- 1g
- Price
- $151
- Updated
- 2021/12/16
- Product number
- CD11088880
- Product name
- 5-Methoxyquinazoline-2,4(1H,3H)-dione
- Purity
- 98%
- Packaging
- 1g
- Price
- $248
- Updated
- 2021/12/16
- Product number
- CM123287
- Product name
- 5-methoxyquinazoline-2,4(1H,3H)-dione
- Purity
- 98%
- Packaging
- 1g
- Price
- $264
- Updated
- 2021/12/16
- Product number
- 61-11189
- Product name
- 5-Methoxyquinazoline-2,4(1H,3H)-dione
- Purity
- 95-98%
- Packaging
- 1g
- Price
- $430
- Updated
- 2021/12/16
2,4(1H,3H)-Quinazolinedione, 5-Methoxy- Chemical Properties,Usage,Production
Synthesis
53600-33-2
61948-86-5
The general procedure for the synthesis of 5-methoxyquinazoline-2,4(1H,3H)-dione from 2-amino-6-methoxybenzoic acid was as follows: 2-amino-6-methoxybenzoic acid (1.25 g, 7.5 mmol) was suspended in a mixed solution of water (45 mL) and acetic acid (0.75 mL) at 35 °C. Subsequently, an aqueous solution of sodium cyanate (1.2 g, 18 mmol) was added dropwise to this suspension (5 mL). After the reaction mixture was reacted under stirring for 0.5 h, sodium hydroxide (13 g, 330 mmol) was added in batches and precipitation was observed to be generated. After the reaction mixture was cooled to room temperature, the pH was adjusted with concentrated hydrochloric acid to 7. The resulting precipitate was collected by filtration, washed thoroughly with water, and dried in an oven to give Intermediate 28 as a white solid (1.0 g, 69% yield).1H NMR (400 MHz, DMSO-d6) δ ppm: 3.80 (s, 3H), 6.68-6.71 (m, 2H). 7.49 (t, J = 8.35Hz, 1H), 10.88 (s, 1H), 10.98 (s, 1H).
References
[1] Journal of the American Chemical Society, 2009, vol. 131, # 48, p. 17605 - 17614
[2] Patent: WO2007/30582, 2007, A2. Location in patent: Page/Page column 91
[3] Patent: US5688803, 1997, A
2,4(1H,3H)-Quinazolinedione, 5-Methoxy- Preparation Products And Raw materials
Raw materials
Preparation Products
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