LEE011 (succinate hydrate)

Product Name: LEE011 (succinate hydrate)
CAS No.: 1374639-79-8
Chemical Name: LEE011 (succinate hydrate)
Synonyms: Ribociclib succite hydrate;LEE011 (succinate hydrate);Ribociclib Succinate hydrat;Ribociclib (succinate hydrate);Ribociclib (LEE011) succinate hydrate;RIBOCICLIB SUCCINATE HYDRATE (LEE011 SUCCINATE HYDRATE)
CBNumber: CB12682009
Molecular Formula: C27H36N8O5
Formula Weight: 552.64
MOL File: 1374639-79-8.mol

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LEE011 (succinate hydrate) Property

storage temp.: Store at -20°C
solubility: DMSO: ≥ 19 mg/mL (33.30 mM)
form: Powder
color: White to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-2278
Product name: Ribociclibsuccinatehydrate
Purity: 99.96%
Packaging: 5mg
Price: $60
Updated: 2021/12/16

ChemScene

Product number: CS-2278
Product name: Ribociclibsuccinatehydrate
Purity: 99.96%
Packaging: 10mg
Price: $84
Updated: 2021/12/16

ChemScene

Product number: CS-2278
Product name: Ribociclibsuccinatehydrate
Purity: 99.96%
Packaging: 50mg
Price: $144
Updated: 2021/12/16

ChemScene

Product number: CS-2278
Product name: Ribociclibsuccinatehydrate
Purity: 99.96%
Packaging: 100mg
Price: $216
Updated: 2021/12/16

Crysdot

Product number: CD31003701
Product name: LEE011succinatehydrate
Purity: 98+%
Packaging: 50mg
Price: $315
Updated: 2021/12/16

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LEE011 (succinate hydrate) Chemical Properties,Usage,Production

Description

LEE011 succinate hydrate is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex.

Uses

Ribociclib succinate hydrate (LEE011 succinate hydrate) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex.

in vitro

In Vitro:Treating a panel of 17 neuroblastoma cell lines with LEE011 (Ribociclib) across a four-log dose range (10 to 10,000 nM). Treatment with LEE011 significantly inhibits substrate adherent growth relative to the control in 12 of the 17 neuroblastoma cell lines examined (mean IC50=306±68 nM, considering sensitive lines only, where sensitivity is defined as an IC50 of less than 1 μM. LEE011 treatment of two neuroblastoma cell lines (BE2C and IMR5) with demonstrated sensitivity to CDK4/6 inhibition results in a dose-dependent accumulation of cells in the G0/G1 phase of the cell cycle. This G0/G1 arrest becomes significant at LEE011 concentrations of 100 nM (p=0.007) and 250 nM (p=0.01), respectively[2].

in vivo

In Vivo:CB17 immunodeficient mice bearing BE2C, NB-1643 (MYCN amplified, sensitive in vitro), or EBC1 (non-amplified, resistant in vitro) xenografts are treated once daily for 21 days with LEE011 (200 mg/kg) or with a vehicle control. This dosing strategy is well tolerated, as no weight loss or other signs of toxicity are observed in any of the xenograft models. Tumor growth is significantly delayed throughout the 21 days of treatment in mice harboring the BE2C or 1643 xenografts (both, p<0.0001), although growth resumed post-treatment[2].

IC 50

CDK4: 10 nM (IC₅₀); CDK6: 39 nM (IC₅₀)

References

References:[1]. VanArsdale T, et al. Molecular Pathways: Targeting the Cyclin D-CDK4/6 Axis for Cancer Treatment. Clin Cancer Res. 2015 Jul 1;21(13):2905-10. [2]. Rader J, et al. Dual CDK4/CDK6 Inhibition Induces Cell-Cycle Arrest and Senescence in Neuroblastoma. Clin Cancer Res. 2013 Nov 15;19(22):6173-82.

LEE011 (succinate hydrate) Preparation Products And Raw materials

Raw materials

Preparation Products

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LEE011 (succinate hydrate) Suppliers

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View Lastest Price from LEE011 (succinate hydrate) manufacturers

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Product: Ribociclib Succinate 1374639-79-8
Price: US $0.00/g
Min. Order: 1g
Purity: More Than 99%
Supply Ability: 100kg/Month
Release date: 2024-08-09

Career Henan Chemical Co

Product: LEE011 (succinate hydrate) 1374639-79-8
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000kg
Release date: 2019-08-31

1374639-79-8, LEE011 (succinate hydrate)Related Search:

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1374639-79-8