ChemicalBook > CAS DataBase List > BOC-LYS-OTBU

BOC-LYS-OTBU

Product Name: BOC-LYS-OTBU
CAS No.: 7750-42-7
Chemical Name: BOC-LYS-OTBU
Synonyms: N2-Boc-L-Lys-OtBu;Boc-Lys-OtBu (Syrup);N-Boc-Lysine Tert-butyl Ester;N2-Boc-L-lysine tert-butyl ester;(Tert-Butoxy)Carbonyl Lys-OtBu (Syrup);tert-butyl N-tert-butyloxycarbonyl-L-lysinate;(S)-tert-Butyl 6-amino-2-((tert-butoxycarbonyl)amino)hexanoate;tert-butyl (2S)-6-amino-2-{[(tert-butoxy)carbonyl]amino}hexanoate;L-Lysine, N2-[(1,1-dimethylethoxy)carbonyl]-, 1,1-dimethylethyl ester;(S)-tert-Butyl 6-amino-2-((tert-butoxycarbonyl)amino)hexanoate - [B92196]
CBNumber: CB12685318
Molecular Formula: C15H30N2O4
Formula Weight: 302.41
MOL File: 7750-42-7.mol

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BOC-LYS-OTBU Property

Boiling point:: 406.7±40.0 °C(Predicted)
Density: 1.021±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
solubility: Chloroform (Sparingly), Methanol (Sparingly)
pka: 11.16±0.46(Predicted)
form: Solid
color: Off-White
optical activity: 7.867°(C=0.01g/ml CHCL3)
InChI: InChI=1S/C15H30N2O4/c1-14(2,3)20-12(18)11(9-7-8-10-16)17-13(19)21-15(4,5)6/h11H,7-10,16H2,1-6H3,(H,17,19)/t11-/m0/s1
InChIKey: LVUBESNUUMLEHL-NSHDSACASA-N
SMILES: C(OC(C)(C)C)(=O)[C@H](CCCCN)NC(OC(C)(C)C)=O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Activate Scientific

Product number: AS116096
Product name: (S)-tert-Butyl 6-amino-2-((tert-butoxycarbonyl)amino)hexanoate
Purity: 97+% ee
Packaging: 250mg
Price: $260
Updated: 2021/12/16

Activate Scientific

Product number: AS116096
Product name: (S)-tert-Butyl 6-amino-2-((tert-butoxycarbonyl)amino)hexanoate
Purity: 97+% ee
Packaging: 1g
Price: $580
Updated: 2021/12/16

Ambeed

Product number: A275334
Product name: (S)-tert-Butyl6-amino-2-((tert-butoxycarbonyl)amino)hexanoate
Purity: 98%
Packaging: 5g
Price: $408
Updated: 2021/12/16

Crysdot

Product number: CD21002833
Product name: (S)-tert-Butyl6-amino-2-((tert-butoxycarbonyl)amino)hexanoate
Purity: 90%
Packaging: 1g
Price: $475
Updated: 2021/12/16

Ambeed

Product number: A275334
Product name: (S)-tert-Butyl6-amino-2-((tert-butoxycarbonyl)amino)hexanoate
Purity: 98%
Packaging: 100mg
Price: $34
Updated: 2021/12/16

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BOC-LYS-OTBU Chemical Properties,Usage,Production

Uses

N-Boc-Lysine Tert-butyl Ester is used in preparation of Tetrahydroisoquinoline derivatives as blood coagulation factor inhibitors useful in the treatment of thromboembolic disorders.

Synthesis

135727-85-4

7750-42-7

General procedure for the synthesis of (S)-6-amino-2-((tert-butoxycarbonyl)amino)hexanoic acid tert-butyl ester from (S)-6-(((benzyloxy)carbonyl)amino)-2-((tert-butoxycarbonyl)amino)hexanoic acid tert-butyl ester: (0133) (0134) (S)-6-(((benzyloxy)carbonyl)amino)-2-((tert-butoxycarbonyl)amino)hexanoic acid tert-butyl ester was butyl ester (98.8 mg, 0.226 mmol) and 10% Pd/C (12.1 mg, 11.4 μmol) were dissolved in methanol (1 mL) and stirred for 2 h at room temperature in a hydrogen atmosphere. Upon completion of the reaction, the solid catalyst was removed by diatomaceous earth filtration and the filtrate was concentrated under reduced pressure to afford tert-butyl (S)-6-amino-2-((tert-butoxycarbonyl)amino)hexanoate in 96% (66.1 mg) yield. The resulting product was used directly in the next reaction without further purification.

References

[1] Angewandte Chemie - International Edition, 2009, vol. 48, # 9, p. 1633 - 1635
[2] Patent: EP2952504, 2015, A1. Location in patent: Paragraph 0133-0134
[3] Tetrahedron Letters, 2014, vol. 55, # 46, p. 6343 - 6346
[4] Journal of Agricultural and Food Chemistry, 2018, vol. 66, # 15, p. 3957 - 3965
[5] Journal of the American Chemical Society, 1997, vol. 119, # 17, p. 4086 - 4087

BOC-LYS-OTBU Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from BOC-LYS-OTBU manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: boc-lys-otbu 7750-42-7
Price: US $1.10-9.90/KG
Min. Order: 1KG
Purity: 99%min
Supply Ability: 100KG
Release date: 2025-08-20

7750-42-7, BOC-LYS-OTBURelated Search:

tert-butyl (2S)-6-amino-2-{[(tert-butoxy)carbonyl]amino}hexanoate

(S)-tert-Butyl 6-amino-2-((tert-butoxycarbonyl)amino)hexanoate

(Tert-Butoxy)Carbonyl Lys-OtBu (Syrup)

tert-butyl N-tert-butyloxycarbonyl-L-lysinate

Boc-Lys-OtBu (Syrup)

L-Lysine, N2-[(1,1-dimethylethoxy)carbonyl]-, 1,1-dimethylethyl ester

N-Boc-Lysine Tert-butyl Ester

N2-Boc-L-lysine tert-butyl ester

N2-Boc-L-Lys-OtBu

tert-butyl (2S)-6-amino-2-[(2-methylpropan-2-yl)oxycarbonylamino]hexanoate

(S)-tert-Butyl 6-amino-2-((tert-butoxycarbonyl)amino)hexanoate - [B92196]

7750-42-7