3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone
- Product Name
- 3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone
- CAS No.
- 342808-40-6
- Chemical Name
- 3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone
- Synonyms
- EF-24;EF24, 10 mM in DMSO;3,5-Bis(2-fluorobenzylidene)piperidin-4-one;5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone;3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone;4-Piperidinone, 3,5-bis[(2-fluorophenyl)methylene]-;(3E,5E)-3,5-bis[(2-fluorophenyl)methylene]-4-piperidinone;ERK,EF24,Caspase,inhibit,Inhibitor,Extracellular signal regulated kinases
- CBNumber
- CB12695159
- Molecular Formula
- C19H15F2NO
- Formula Weight
- 311.33
- MOL File
- 342808-40-6.mol
3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone Property
- storage temp.
- -20°C
- solubility
- DMSO: ≥10mg/mL
- form
- powder
- color
- yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H400Very toxic to aquatic life
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P273Avoid release to the environment.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P391Collect spillage. Hazardous to the aquatic environment
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- E8409
- Product name
- EF-24
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $76.3
- Updated
- 2025/07/31
- Product number
- E8409
- Product name
- EF-24
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $431
- Updated
- 2025/07/31
- Product number
- B434770
- Product name
- 3,5-Bis[(2-fluorophenyl)methylene]-4-piperidinone
- Packaging
- 2.5g
- Price
- $1650
- Updated
- 2021/12/16
- Product number
- CHM0151819
- Product name
- (3E,5E)-3,5-BIS[(2-FLUOROPHENYL)METHYLENE]-4-PIPERIDINONE
- Purity
- 95.00%
- Packaging
- 10MG
- Price
- $1963.5
- Updated
- 2021/12/16
- Product number
- CHM0151819
- Product name
- (3E,5E)-3,5-BIS[(2-FLUOROPHENYL)METHYLENE]-4-PIPERIDINONE
- Purity
- 95.00%
- Packaging
- 1MG
- Price
- $750.75
- Updated
- 2021/12/16
3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone Chemical Properties,Usage,Production
Uses
3,5-Bis[(2-fluorophenyl)methylene]-4-piperidinone is an analog of curcumin that acts as a kinase inhibitor which mediates anticancer properties.
Biological Activity
EF-24 is a IKK inhibitor and curcumin analog. EF-24 is more potent and bioavailable than curcumin, with 10-fold greater potency in cell death induction. It is also more efficacious in anti-cancer screens and less toxic than Cisplatin. EF-24 inhibits HIF-1alpha posttranscriptional activity and induces microtubule stabilization, in contrast to Curcumin. EF-24 up-regulates PTEN expression via inhibition of ubiquitination. EF-24 induces cell death through direct inhibition of IkappaB kinase (IKK), resulting in suppression in NFKB activity.', 'EF-24 is a IKK inhibitor and curcumin analog. EF-24 is more potent and bioavailable than curcumin, with 10-fold greater potency in cell death induction. It is also more efficacious in anti-cancer screens and less toxic than Cisplatin. EF-24 inhibits HIF-1α posttranscriptional activity and induces microtubule stabilization, in contrast to Curcumin. EF-24 up-regulates PTEN expression via inhibition of ubiquitination. EF-24 induces cell death through direct inhibition of IK B kinase (IKK), resulting in suppression in NFKB activity. EF-24/(3E,5E)-3,5-bis[(2-fluorophenyl)methylene]-4-piperidinone is a curcuminoid, th at helps to decrease cisplatin-mediated reactive oxygen species in zebrafish. It is highly bioavailable than curcumin and has the ability to target cancer.
in vivo
EF24 (0.4 mg/kg, i.p., a single dose for 6 h) markedly ameliorates the post-hemorrhage morphologic changes and inflammatory cell infiltration, inhibits hemorrhage-induced NF-kB phosphorylation in rat model of hemorrhage[4].
| Animal Model: | Rat model of hemorrhage[4] |
| Dosage: | 0.4 mg/kg |
| Administration: | i.p., a single dose for 6 h |
| Result: | Prevented the hemorrhage-induced increase in myeloperoxidase activity and phospho-NF-kB p65 in hemorrhaged lung tissue. |
3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone Preparation Products And Raw materials
Raw materials
Preparation Products
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