ChemicalBook > CAS DataBase List > PNU-159682

PNU-159682

Product Name
PNU-159682
CAS No.
202350-68-3
Chemical Name
PNU-159682
Synonyms
PNU-159682;PNU-159682 95%;PNU-159682 >95%; 5-hydroxy-6-tert.-butyl-1,1-pentamethylene-3,3-dimethyl-indane;inhibit,non-Hodgkin’s lymphoma,PNU159682,ADCs Toxin,PNU-159682,acute myeloid leukemia,ADC Payload,EDV nanocell,AML,Inhibitor,ADC Cytotoxin,PNU 159682,Topoisomerase,NMS249,NHL;(8S,10S)-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-10-{[(2S,4R,6S,7S,9R,10S)-10-methoxy-6-methyl-5,8,11-trioxa-1-azatricyclo[7.4.0.02,?]tridecan-4-yl]oxy}-5,7,8,9,10,12-hexahydrotetracene-5,12-dione;(8S,10S)-6,8,11-Trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-10-(((1S,3R,4aS,9S,9aR,10aS)-9-methoxy-1-methyloctahydro-1H-pyrano[4',3':4,5]oxazolo[2,3-c][1,4]oxazin-3-yl)oxy)-7,8,9,10-tetrahydrotetracene-5,12-dione;(8S,10S)-7,8,9,10-Tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-10-[[(1S,3R,4aS,9S,9aR,10aS)-octahydro-9-methoxy-1-methyl-1H-pyrano[4',3':4,5]oxazolo[2,3-c][1,4]oxazin-3-yl]oxy]-5,12-naphthacenedione;5,12-Naphthacenedione, 7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-10-[[(1S,3R,4aS,9S,9aR,10aS)-octahydro-9-methoxy-1-methyl-1H-pyrano[4',3':4,5]oxazolo[2,3-c][1,4]oxazin-3-yl]oxy]-, (8S,10S)-
CBNumber
CB12702958
Molecular Formula
C32H35NO13
Formula Weight
641.62
MOL File
202350-68-3.mol
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PNU-159682 Property

Boiling point:
838.5±65.0 °C(Predicted)
Density 
1.58±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
DMSO: 2mg/mL, clear
form 
Solid
pka
7.34±0.60(Predicted)
color 
Reddish Brown to red
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-3298
Product name
PNU-159682
Purity
97.24%
Packaging
5mg
Price
$750
Updated
2021/12/16
ChemScene
Product number
CS-3298
Product name
PNU-159682
Purity
97.24%
Packaging
10mg
Price
$1000
Updated
2021/12/16
ChemScene
Product number
CS-3298
Product name
PNU-159682
Purity
97.24%
Packaging
50mg
Price
$2400
Updated
2021/12/16
Crysdot
Product number
CD31002752
Product name
PNU-159682
Purity
98+%
Packaging
50mg
Price
$3750
Updated
2021/12/16
Crysdot
Product number
CD31002752
Product name
PNU-159682
Purity
98+%
Packaging
100mg
Price
$6150
Updated
2021/12/16
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PNU-159682 Chemical Properties,Usage,Production

Characteristics

PNU-159682, a metabolite of the anthracycline neomycin metabolite, is a DNA topoisomerase I (TopoI) inhibitor with excellent cytotoxicity. It is a more potent and tolerable ADC cytotoxin than doxorubicin in ADC synthesis.

Uses

PNU-159682 can be used in EDV nanocell technology to overcome drug resistance.

Biological Activity

PNU-159682, an active nemorubicin metabolite, is a highly potent anthracycline toxin th at retains antitumor activity in vivo. Similarly to other anthracyclines PNU-159682 intercalates between the CG base pairs of DNA, but the stability of the complexes is much higher.

PNU-159682 Preparation Products And Raw materials

Raw materials

Preparation Products

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PNU-159682 Suppliers

China 78 United States 8 Global 86
WuYan Pharmaceutical Technology (Shanghai) Co., Ltd.
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View Lastest Price from PNU-159682 manufacturers

Wuhan Topule Biopharmaceutical Co., Ltd
Product
PNU-159682 202350-68-3
Price
US $10.00/mg
Min. Order
10mg
Purity
95%+
Supply Ability
500g
Release date
2023-06-13
Career Henan Chemical Co
Product
PNU-159682 202350-68-3
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2020-02-13

202350-68-3, PNU-159682Related Search:


  • PNU-159682
  • PNU-159682 >95%
  • (8S,10S)-7,8,9,10-Tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-10-[[(1S,3R,4aS,9S,9aR,10aS)-octahydro-9-methoxy-1-methyl-1H-pyrano[4',3':4,5]oxazolo[2,3-c][1,4]oxazin-3-yl]oxy]-5,12-naphthacenedione
  • PNU-159682 95%
  • 5,12-Naphthacenedione, 7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-10-[[(1S,3R,4aS,9S,9aR,10aS)-octahydro-9-methoxy-1-methyl-1H-pyrano[4',3':4,5]oxazolo[2,3-c][1,4]oxazin-3-yl]oxy]-, (8S,10S)-
  • 5-hydroxy-6-tert.-butyl-1,1-pentamethylene-3,3-dimethyl-indane
  • inhibit,non-Hodgkin’s lymphoma,PNU159682,ADCs Toxin,PNU-159682,acute myeloid leukemia,ADC Payload,EDV nanocell,AML,Inhibitor,ADC Cytotoxin,PNU 159682,Topoisomerase,NMS249,NHL
  • (8S,10S)-6,8,11-Trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-10-(((1S,3R,4aS,9S,9aR,10aS)-9-methoxy-1-methyloctahydro-1H-pyrano[4',3':4,5]oxazolo[2,3-c][1,4]oxazin-3-yl)oxy)-7,8,9,10-tetrahydrotetracene-5,12-dione
  • (8S,10S)-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-10-{[(2S,4R,6S,7S,9R,10S)-10-methoxy-6-methyl-5,8,11-trioxa-1-azatricyclo[7.4.0.02,?]tridecan-4-yl]oxy}-5,7,8,9,10,12-hexahydrotetracene-5,12-dione
  • 202350-68-3