FLLL32
- Product Name
- FLLL32
- CAS No.
- 1226895-15-3
- Chemical Name
- FLLL32
- Synonyms
- FLLL32;CS-1778;EX-A1096;FLLL32;FLLL-32;FLLL 32;FLLL-32;FLLL 32;EX-A1096;(2E,2'E)-1,1'-cyclohexylidenebis[3-(3,4-diMethoxyphenyl)-2-Propen-1-one;FLLL32,Apoptosis,inhibit,JAK,Inhibitor,STAT,Janus kinase,FLLL-32,FLLL 32;(2E,2'E)-1,1'-(cyclohexane-1,1-diyl)bis(3-(3,4-dimethoxyphenyl)prop-2-en-1-one);(2E,2'E)-1,1'-(cyclohexane-1,1-diyl)bis(3-(3,4-dimethoxyphenyl)prop-2-en-1-one) FLLL32
- CBNumber
- CB12704932
- Molecular Formula
- C28H32O6
- Formula Weight
- 464.55008
- MOL File
- 1226895-15-3.mol
FLLL32 Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- insoluble in H2O; ≥2.58 mg/mL in EtOH; ≥55.4 mg/mL in DMSO
- form
- crystalline solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P272Contaminated work clothing should not be allowed out of the workplace.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P363Wash contaminated clothing before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 10638
- Product name
- FLLL32
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $39
- Updated
- 2024/03/01
- Product number
- 10638
- Product name
- FLLL32
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $96
- Updated
- 2024/03/01
- Product number
- 10638
- Product name
- FLLL32
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $134
- Updated
- 2024/03/01
- Product number
- 10638
- Product name
- FLLL32
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $236
- Updated
- 2024/03/01
- Product number
- F401400
- Product name
- FLLL32
- Packaging
- 25mg
- Price
- $485
- Updated
- 2021/12/16
FLLL32 Chemical Properties,Usage,Production
Uses
FLLL32 is a potent JAK2/STAT3 inhibitor used in the treatment of osteosarcomas, or malignant bone tumors.
Biological Activity
flll32 is a small molecule analog of curcumin. it can inhibit signal transducer and activator of transcription-3 (stat3). in the pstat3-positive a375 cell line, flll32 resulted in pro-apoptotic effects with an ic50 value of 1.3 μm at 48 hours [1].activation of stat3 in melanoma tumors is related to poor prognosis. stat3 can promote angiogenesis and cell proliferation, drive invasion and metastasis, and inhibit apoptosis [1].in multiple human melanoma cell lines, after a 24 hour treatment with flll32, the stat3 phosphorylation at tyr705 but not at tyr727 was inhibited. in a prior in vitro cell-free assay, flll32 was found to inhibit the activity of jak2 kinase. but in the experiment with multiple human melanoma cell line, no appreciable alteration in the phosphorylation of jak2, even when the concentration of flll32 was 8 μm, was observed. this meant that flll32 likely directly acted against the stat3 protein. flll32 at concentrations ranged from 2-4 μm for only 4 hours reduced pstat3 and induce cell death [1].in an s.c. model of b16f10 melanoma in c57bl/6 mice, compared to the treatment with dmso to the same animals, daily i.p. administration of flll-32 at concentrations of 25 mg/kg and 50 mg/kg significantly delayed tumor growth (p<0.001) [2].
References
[1]. bill ma, fuchs jr, li c, et al. the small molecule curcumin analog flll32 induces apoptosis in melanoma cells via stat3 inhibition and retains the cellular response to cytokines with anti-tumor activity. molecular cancer, 2010, 9(1): 165.
[2]. lesinski g, bill m, li c, et al. abstract# 856: the small molecule curcumin analog flll-32 induces apoptosis in human melanoma cells via stat3 inhibition and elicits in vivo anti-tumor activity. cancer research, 2009, 69(9 supplement): 856-856.
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