GNF179

Product Name: GNF179
CAS No.: 1261114-01-5
Chemical Name: GNF179
Synonyms: GNF179;GNF179, 10 mM in DMSO;GNF 179,GNF-179,Parasite,inhibit,GNF179,Inhibitor;2-amino-1-[3-(4-chloroanilino)-2-(4-fluorophenyl)-8,8-dimethyl-5,6-dihydroimidazo[1,2-a]pyrazin-7-yl]ethanone;2-amino-1-{3-[(4-chlorophenyl)amino]-2-(4-fluorophenyl)-8,8-dimethyl-5H,6H,7H,8H-imidazo[1,2-a]pyrazin-7-yl}ethan-1-one;2-Amino-1-[3-[(4-chlorophenyl)amino]-2-(4-fluorophenyl)-5,6-dihydro-8,8-dimethylimidazo[1,2-a]pyrazin-7(8H)-yl]ethanone;Ethanone, 2-amino-1-[3-[(4-chlorophenyl)amino]-2-(4-fluorophenyl)-5,6-dihydro-8,8-dimethylimidazo[1,2-a]pyrazin-7(8H)-yl]-;2-amino-1-(3-((4-chlorophenyl)amino)-2-(4-fluorophenyl)-8,8-dimethyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)ethan-1-one
CBNumber: CB12705085
Molecular Formula: C22H23ClFN5O
Formula Weight: 427.9
MOL File: 1261114-01-5.mol

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GNF179 Property

Boiling point:: 656.2±55.0 °C(Predicted)
Density: 1.36±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: ≥ 125 mg/mL (292.12 mM)
pka: 7.94±0.29(Predicted)
form: Powder
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: A617584
Product name: 2-Amino-1-(3-((4-chlorophenyl)amino)-2-(4-fluorophenyl)-8,8-dimethyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)ethanone
Packaging: 10mg
Price: $1650
Updated: 2021/12/16

ChemScene

Product number: CS-2796
Product name: GNF179
Purity: 99.28%
Packaging: 50mg
Price: $1650
Updated: 2021/12/16

ChemScene

Product number: CS-2796
Product name: GNF179
Purity: 99.28%
Packaging: 100mg
Price: $2450
Updated: 2021/12/16

ChemScene

Product number: CS-2796
Product name: GNF179
Purity: 99.28%
Packaging: 5mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-2796
Product name: GNF179
Purity: 99.28%
Packaging: 10mg
Price: $580
Updated: 2021/12/16

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GNF179 Chemical Properties,Usage,Production

Uses

2-Amino-1-(3-((4-chlorophenyl)amino)-2-(4-fluorophenyl)-8,8-dimethyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)ethanone also known as GNF 179 is used in the imaging of plasmodium parasites for next generation antimalarial drug discovery.

in vivo

GNF179 (15 mg/kg; p.o.; single dose) shows antimalarial activity in rodent malaria model^[1].

Animal Model:	Na?ve Balb/C mice infected with P. berghei^[1]
Dosage:	15 mg/kg
Administration:	Oral, single dose
Result:	Protected against an infectious P. berghei sporozoite.

Animal Model:

Na?ve Balb/C mice^[1]

Dosage:

3 or 20 mg/kg

Administration:

IV or PO (Pharmacokinetic Analysis)

Result:

Pharmacokinetics of GNF179 in na?ve Balb/C mice.

Dose	AUC_(0-∞) (hrs*μM)	AUC/dose	t_1/2 (hrs)	MRT (hrs)	CL (ml/min/kg)	V_ss (L/kg)	C₀ or C_max (μM)	F (%)
3 mg/kg i.v.	8.88	3.0	8.9	9.0	22	11.8	6.1	nd
20 mg/kg p.o.	20.70	1.0	8.4	nd	nd	nd	1.2	58

AUC, Area Under the Curve; T_1/2, half life; CL, clearance; V_SS, steady-state volume of distribution; C₀, initial concentration; C_max maximum concentration; F, fraction of dose absorbed; hrs, hours; nd, not determined.

IC 50

Plasmodium

GNF179 Preparation Products And Raw materials

Raw materials

Preparation Products

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GNF179 Suppliers

China 46 India 1 United States 5 Global 52

MedChemexpress LLC

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Nanjing KaiMubo Pharmaceutical Co., Ltd.

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1261114-01-5, GNF179Related Search:

GNF179

2-Amino-1-[3-[(4-chlorophenyl)amino]-2-(4-fluorophenyl)-5,6-dihydro-8,8-dimethylimidazo[1,2-a]pyrazin-7(8H)-yl]ethanone

2-amino-1-(3-((4-chlorophenyl)amino)-2-(4-fluorophenyl)-8,8-dimethyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)ethan-1-one

Ethanone, 2-amino-1-[3-[(4-chlorophenyl)amino]-2-(4-fluorophenyl)-5,6-dihydro-8,8-dimethylimidazo[1,2-a]pyrazin-7(8H)-yl]-

2-amino-1-[3-(4-chloroanilino)-2-(4-fluorophenyl)-8,8-dimethyl-5,6-dihydroimidazo[1,2-a]pyrazin-7-yl]ethanone

GNF 179,GNF-179,Parasite,inhibit,GNF179,Inhibitor

2-amino-1-{3-[(4-chlorophenyl)amino]-2-(4-fluorophenyl)-8,8-dimethyl-5H,6H,7H,8H-imidazo[1,2-a]pyrazin-7-yl}ethan-1-one

GNF179, 10 mM in DMSO

1261114-01-5