Nrf1-activator-1

ChemicalBook > CAS DataBase List > Nrf1-activator-1

Product Name: Nrf1-activator-1
CAS No.: 1474034-05-3
Chemical Name: Nrf1-activator-1
Synonyms: CS-1306;RTA-408;Omaveloxolone;Nrf1-activator-1;RTA-408;RTA 408;RTA408;RTA-408(Omaveloxolone);Omaveloxolone (RTA-408);Clopidogrel Impurity 115;N-(2-Cyano-3,12-dioxo-28-noroleana-1,9(11)-dien-17-yl)-2,2-difluoropropanamide;Propanamide, N-(2-cyano-3,12-dioxo-28-noroleana-1,9(11)-dien-17-yl)-2,2-difluoro-
CBNumber: CB12705090
Molecular Formula: C33H44F2N2O3
Formula Weight: 554.71
MOL File: 1474034-05-3.mol

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Nrf1-activator-1 Property

Boiling point:: 662.0±55.0 °C(Predicted)
Density: 1.19±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≥55.5 mg/mL in DMSO; insoluble in H2O; ≥25.05 mg/mL in EtOH
form: Powder
pka: 13.71±0.70(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 17854
Product name: RTA 408
Purity: ≥98%
Packaging: 1mg
Price: $61
Updated: 2024/03/01

Cayman Chemical

Product number: 17854
Product name: RTA 408
Purity: ≥98%
Packaging: 5mg
Price: $250
Updated: 2024/03/01

Cayman Chemical

Product number: 17854
Product name: RTA 408
Purity: ≥98%
Packaging: 10mg
Price: $468
Updated: 2024/03/01

Cayman Chemical

Product number: 17854
Product name: RTA 408
Purity: ≥98%
Packaging: 25mg
Price: $1019
Updated: 2024/03/01

TRC

Product number: R700990
Product name: RTA408
Packaging: 25mg
Price: $1155
Updated: 2021/12/16

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Nrf1-activator-1 Chemical Properties,Usage,Production

Uses

Synthetic triterpenoids, such as RTA 408, are antioxidant inflammation modulator (AIM) that can inhibit tumor cell growth and metastasis via oncogenic signaling pathways. RTA 408 is an anticancer, anti-inflammatory, and antioxidant agent that protects human retinal pigment epithelial cells against H2O2-induced cell injury by activating NF-E2-related factor 2.

Biological Activity

omaveloxolone (rta-408) is a novel synthetic triterpenoid that binds to kelch-like ech-associated protein 1 (keap1) and attenuate nuclear factor erythroid 2-related factor 2 (nrf2) degradation [1].keap1 is involved in proteasomal degradation of nrf2, thereby maintaining low basal levels of nrf2. binding to keap1 and blocking its ability to promote nrf2 degradation increase newly synthesized nrf2 accumulated in the nucleus where nrf2 increases the expression of antioxidant genes and decreases the expression of pro-inflammatory genes [1].in interferon-γ-stimulated raw 264.7 macrophage cells, low concentrations (≤ 25 nm) of rta-408 activated nrf2 and lowered nitric oxide and pro-inflammatory cytokine levels. at higher concentrations, rta-408 inhibited tumor cell growth, with gi50 of 260 ± 74 nm. meanwhile, rta-408 increased caspase activity in tumor cell lines, but not in normal primary human cells.in mice with radiation-induced dermatitis, topical application of rta-408 (0.01%, 0.1% and 1.0%, q.d.) resulted in dose-dependent improvements in the appearance of skin, with 1.0% rta-408 markedly reducing epidermal and collagen thickening, preventing dermal necrosis, and completely alleviating skin ulcers [2].[1]. probst b l, trevino i, mccauley l, et al. rta 408, a novel synthetic triterpenoid with broad anticancer and anti-inflammatory activity. plos one, 2015, 10(4): e0122942.[2]. reisman s a, lee c y, meyer c j, et al. topical application of the synthetic triterpenoid rta 408 protects mice from radiation-induced dermatitis. radiation research, 2014, 181(5): 512-520.

Nrf1-activator-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Nrf1-activator-1 manufacturers

Career Henan Chemical Co

Product: RTA-408 1474034-05-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2019-12-30

1474034-05-3, Nrf1-activator-1Related Search:

N-(2-Cyano-3,12-dioxo-28-noroleana-1,9(11)-dien-17-yl)-2,2-difluoropropanamide

Nrf1-activator-1

RTA-408

Omaveloxolone (RTA-408)

Omaveloxolone

RTA-408;RTA 408;RTA408

CS-1306

Propanamide, N-(2-cyano-3,12-dioxo-28-noroleana-1,9(11)-dien-17-yl)-2,2-difluoro-

RTA-408(Omaveloxolone)

Inhibitor,Omaveloxolone,Apoptosis,RTA 408,RTA408,ERIS,STING,inhibit,Stimulator of Interferon Genes,TMEM173,MITA,Keap1-Nrf2,MPYS

N-((4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-Cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,3,4,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-hexadecahydropicen-4a(2H)-yl)-2,2-difluoropropanamide

Clopidogrel Impurity 115

1474034-05-3

C33H44F2N2O3

APIs

Omaveloxolone