ChemicalBook > CAS DataBase List > 2-Hydroxy Atorvastatin Calcium Salt

2-Hydroxy Atorvastatin Calcium Salt

Product Name
2-Hydroxy Atorvastatin Calcium Salt
CAS No.
265989-46-6
Chemical Name
2-Hydroxy Atorvastatin Calcium Salt
Synonyms
Atorvastatin Impurity K;2-Hydroxy Atorvastatin Sodium;Atorvastatin 2-Hydroxy Calcium Salt;2-Hydroxy Atorvastatin CalciuM Salt;di(2-Hydroxy Atorvastatin) CalciuM Salt;2-Hydroxy atorvastatin calcium salt, 10 mM in DMSO;inhibit,2-Hydroxy atorvastatin,2Hydroxy atorvastatin calcium salt,Drug Metabolite,Inhibitor,2 Hydroxy atorvastatin calcium salt;calcium,(3S,5S)-7-[2-(4-fluorophenyl)-4-[(2-hydroxyphenyl)carbamoyl]-3-phenyl-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoate;Atorvastatin impurity 39/Atorvastatin 2-Hydroxy Calcium Salt/ortho-Hydroxy Atorvastatin Calcium Salt/(3R,5R)-7-[3-(2-Hydroxyphenylcarbamoyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl]-3,5;Atorvastatin impurity 39/Atorvastatin 2-Hydroxy Calcium Salt/ortho-Hydroxy Atorvastatin Calcium Salt/(3R,5R)-7-[3-(2-Hydroxyphenylcarbamoyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid calcium salt
CBNumber
CB12709452
Molecular Formula
C33H37CaFN2O6
Formula Weight
616.74
MOL File
265989-46-6.mol
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2-Hydroxy Atorvastatin Calcium Salt Property

Melting point:
>166°C (dec.)
storage temp. 
Hygroscopic, Refrigerator, under inert atmosphere
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
color 
White to Yellow
Stability:
Hygroscopic
InChIKey
HXHTYJCMZMIHOD-VIMLIWADNA-N
SMILES
C(C1=C(N(CC[C@@H](O)C[C@@H](O)CC(=O)O)C(C2C=CC(F)=CC=2)=C1C1C=CC=CC=1)C(C)C)(=O)NC1C=CC=CC=1O.[Ca] |&1:6,9,r|
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
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N-Bromosuccinimide Price

Cayman Chemical
Product number
30974
Product name
2-hydroxy Atorvastatin (calcium salt)
Packaging
1mg
Price
$242
Updated
2024/03/01
TRC
Product number
H828930
Product name
2-HydroxyAtorvastatinCalciumSalt
Packaging
1mg
Price
$135
Updated
2021/12/16
Usbiological
Product number
280154
Product name
2-Hydroxy atorvastatin calcium salt
Packaging
5mg
Price
$1204
Updated
2021/12/16
TRC
Product number
H828930
Product name
2-HydroxyAtorvastatinCalciumSalt
Packaging
100mg
Price
$4540
Updated
2021/12/16
ChemScene
Product number
CS-0100506
Product name
2-Hydroxyatorvastatincalciumsalt
Purity
97.68%
Packaging
1mg
Price
$150
Updated
2021/12/16
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2-Hydroxy Atorvastatin Calcium Salt Chemical Properties,Usage,Production

Chemical Properties

White to Pale Yellow Solid

Uses

di(2-Hydroxy Atorvastatin) Calcium Salt is a metabolite of Atorvastatin Calcium Salt (A791750), a selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.

Biological Activity

2-Hydroxy atorvastatin calcium salt is a hydroxy metabolite of Atorvastatin calcium salt. Atorvastatin is a potent HMG-CoA reductase inhibitor with an IC50 value of 8 nM. It inhibits lipid hydroperoxide formation and copper sulfate-induced thiobarbituric acid reactive substances (TBARS) formation in 1,2-dilinoleoyl-sn-glycero-3-PC (DLPC) vesicles and human LDL, respectively, in a concentration-dependent manner. 2-Hydroxy Atorvastatin reduces cell death induced by oxygen-glucose deprivation (OGD) in primary rat cortical neurons and increases phosphorylation of cAMP-response-element-binding protein (CREB) in GABAergic neurons when used at a concentration of 600 nM following OGD.

2-Hydroxy Atorvastatin Calcium Salt Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Hydroxy Atorvastatin Calcium Salt Suppliers

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265989-46-6, 2-Hydroxy Atorvastatin Calcium SaltRelated Search:

Dihydroxy Diketo Atorvastatin IMpurity 3-Oxo Atorvastatin tert-Butyl Ester Atorvastatin Impurity 31 Atorvastatin Impurity 15 2-[1,2-Bis-(4-fluoro-phenyl)-2-oxo-ethyl]-4-methyl-3-oxo-pentanoic acid phenylamide 2,3-Dehydroxy Atorvastatin Sodium Salt Atorvastatin Impurity 20 Atorvastatin IMpurity G Ortho-Hydroxy atorvastatin calcium salt O-HYDROXY ATORVASTATIN LACTONE ATV-FX1 sodiuM salt 5-Oxo Atorvastatin tert-Butyl Ester Atorvastatin Impurity 46 Atorvastatin Impurity 38 Atorvastatin Difluoro Atorvastatin Acetonide tert-Butyl Ester Atorvastatin Dehydro Lactone 3S,5R isoMer, or (3S,5R)-7-[3-(phenylcarbaMoyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid calciuM salt

  • 2-Hydroxy Atorvastatin CalciuM Salt
  • 2-Hydroxy Atorvastatin Sodium
  • Atorvastatin Impurity K
  • Atorvastatin impurity 39/Atorvastatin 2-Hydroxy Calcium Salt/ortho-Hydroxy Atorvastatin Calcium Salt/(3R,5R)-7-[3-(2-Hydroxyphenylcarbamoyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid calcium salt
  • calcium,(3S,5S)-7-[2-(4-fluorophenyl)-4-[(2-hydroxyphenyl)carbamoyl]-3-phenyl-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoate
  • 2-Hydroxy Atorvastatin D5 Calcium SaltQ: What is 2-Hydroxy Atorvastatin D5 Calcium Salt Q: What is the CAS Number of 2-Hydroxy Atorvastatin D5 Calcium Salt Q: What is the storage condition of 2-Hydroxy Atorvastatin D5 Calcium Salt Q: What are the applications of 2-Hydroxy Atorvastatin D5 Calcium Salt
  • 2-Hydroxy Atorvastatin Calcium SaltQ: What is 2-Hydroxy Atorvastatin Calcium Salt Q: What is the CAS Number of 2-Hydroxy Atorvastatin Calcium Salt Q: What is the storage condition of 2-Hydroxy Atorvastatin Calcium Salt Q: What are the applications of 2-Hydroxy Atorvastatin Calcium Salt
  • inhibit,2-Hydroxy atorvastatin,2Hydroxy atorvastatin calcium salt,Drug Metabolite,Inhibitor,2 Hydroxy atorvastatin calcium salt
  • di(2-Hydroxy Atorvastatin) CalciuM Salt
  • 2-Hydroxy atorvastatin calcium salt, 10 mM in DMSO
  • Atorvastatin 2-Hydroxy Calcium Salt
  • Atorvastatin impurity 39/Atorvastatin 2-Hydroxy Calcium Salt/ortho-Hydroxy Atorvastatin Calcium Salt/(3R,5R)-7-[3-(2-Hydroxyphenylcarbamoyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl]-3,5
  • 265989-46-6
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