2-AMino-5-chloro-4'-hydroxybenzophenone
- Product Name
- 2-AMino-5-chloro-4'-hydroxybenzophenone
- CAS No.
- 784-41-8
- Chemical Name
- 2-AMino-5-chloro-4'-hydroxybenzophenone
- Synonyms
- DIAZEPAM - IN HOUSE IMPURITY;2-AMino-5-chloro-4'-hydroxybenzophenone;Methanone, (2-amino-5-chlorophenyl)(4-hydroxyphenyl)-;(2-Amino-5-chloro-phenyl)-(4-hydroxy-phenyl)-methanone
- CBNumber
- CB12709922
- Molecular Formula
- C13H10ClNO2
- Formula Weight
- 247.68
- MOL File
- 784-41-8.mol
2-AMino-5-chloro-4'-hydroxybenzophenone Property
- Melting point:
- 174°C
- solubility
- soluble in DCM, Ethyl Acetate
- form
- Solid
- color
- Yellow
N-Bromosuccinimide Price
- Product number
- A603980
- Product name
- 2-Amino-5-chloro-4''-hydroxybenzophenone
- Packaging
- 100mg
- Price
- $580
- Updated
- 2021/12/16
- Product number
- 43010
- Product name
- 2-Amino-5-chloro-4??-hydroxybenzophenone
- Packaging
- 25mg
- Price
- $675
- Updated
- 2021/12/16
2-AMino-5-chloro-4'-hydroxybenzophenone Chemical Properties,Usage,Production
Uses
2-Amino-5-chloro-4'-hydroxybenzophenone is an intermediate in the preparation of Diazepam (D416855), an anxiolytic agent, muscle relaxant and anticonvulsant agent.
Preparation
Preparation by cleavage of 5-chloro-3-(phydroxyphenyl)- 2,1-benzisoxazole (other name: 5-chloro-3-(p-hydroxy-phenyl)anthranil) (SM),
? by heating at reflux with aluminium iodide for 50 min (87%);
? by reaction with concentrated hydrochloric acid and an excess of tin in boiling ethanol or acetic acid. SM (m.p. 241°) was prepared by condensation of o-nitrobenzaldehyde with phenol in the presence of hydrogen chloride or phosphorous oxychloride in cold acetic acid;
? by hydrogenation in the presence of 10% Pd/C in ethyl acetate between 40° and 60° at a pressure of 3 atmospheres (quantitative yield).
2-AMino-5-chloro-4'-hydroxybenzophenone Preparation Products And Raw materials
Raw materials
Preparation Products
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