ChemicalBook > CAS DataBase List > AGN 196996
AGN 196996
- Product Name
- AGN 196996
- CAS No.
- 958295-17-5
- Chemical Name
- AGN 196996
- Synonyms
- CS-1210;VTP 196696;AGN 196996;Benzoic acid, 4-[[3-bromo-4-ethoxy-5-(4-methylbenzoyl)benzoyl]amino]-
- CBNumber
- CB12715604
- Molecular Formula
- C24H20BrNO5
- Formula Weight
- 482.32
- MOL File
- 958295-17-5.mol
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AGN 196996 Property
- storage temp.
- Store at -20°C
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- form
- Powder
- color
- White to off-white
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N-Bromosuccinimide Price
Crysdot
- Product number
- CD31000069
- Product name
- AGN196996
- Purity
- 98+%
- Packaging
- 5mg
- Price
- $245
- Updated
- 2021/12/16
Crysdot
- Product number
- CD31000069
- Product name
- AGN196996
- Purity
- 98+%
- Packaging
- 10mg
- Price
- $350
- Updated
- 2021/12/16
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AGN 196996 Chemical Properties,Usage,Production
Description
AGN 196996 is a potent and selective RARα antagonist with Ki value of 2 nM; little binding affinity for RARβ(Ki=1087 nM) and RARγ(Ki=8523 nM). IC50 value: 2 nM(Ki) Target: RARα antagonist AGN 196996 shows no activity in transactivation assays, but instead block the gene transcriptional activity induced by ATRA and other RAR agonists.
References
References:[1]. Hammond LA, et al. Antagonists of retinoic acid receptors (RARs) are potent growth inhibitors of prostate carcinoma cells. Br J Cancer. 2001 Aug 3;85(3):453-62. [2]. Keedwell RG, et al. An antagonist of retinoic acid receptors more effectively inhibits growth of human prostate cancer cells than normal prostate epithelium. Br J Cancer. 2004 Aug 2;91(3):580-8.
AGN 196996 Preparation Products And Raw materials
Raw materials
Preparation Products
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