3-aMino-5-chloro-N-cyclopropyl-4-Methyl-6-(2-(4-Methylpiperazin-1-yl)-2-oxoethoxy)thieno[2,3-b]pyridine-2-carboxaMide

ChemicalBook > CAS DataBase List > 3-aMino-5-chloro-N-cyclopropyl-4-Methyl-6-(2-(4-Methylpiperazin-1-yl)-2-oxoethoxy)thieno[2,3-b]pyridine-2-carboxaMide

3-aMino-5-chloro-N-cyclopropyl-4-Methyl-6-(2-(4-Methylpiperazin-1-yl)-2-oxoethoxy)thieno[2,3-b]pyridine-2-carboxaMide

Product Name: 3-aMino-5-chloro-N-cyclopropyl-4-Methyl-6-(2-(4-Methylpiperazin-1-yl)-2-oxoethoxy)thieno[2,3-b]pyridine-2-carboxaMide
CAS No.: 886047-22-9
Chemical Name: 3-aMino-5-chloro-N-cyclopropyl-4-Methyl-6-(2-(4-Methylpiperazin-1-yl)-2-oxoethoxy)thieno[2,3-b]pyridine-2-carboxaMide
Synonyms: CS-2803;LY2119620;Muscarinic acetylcholine receptor,Inhibitor,inhibit,mAChR,LY-2119620,LY 2119620,LY2119620;3-aMino-5-chloro-N-cyclopropyl-4-Methyl-6-(2-(4-Methylpiperazin-1-yl)-2-oxoethoxy)thieno[2,3-b]pyridine-2-carboxaMide;3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methyl-1-piperazinyl)-2-oxoethoxy]-thieno[2,3-b]pyridine-2-carboxamide;Thieno[2,3-b]pyridine-2-carboxamide,3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methyl-1-piperazinyl)-2-oxoethoxy]-;3-aMino-5-chloro-N-cyclopropyl-4-Methyl-6-(2-(4-Methylpiperazin-1-yl)-2-oxoethoxy)thieno[2,3-b]pyridine-2-carboxaMide USP/EP/BP
CBNumber: CB12716025
Molecular Formula: C19H24ClN5O3S
Formula Weight: 437.94
MOL File: 886047-22-9.mol

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3-aMino-5-chloro-N-cyclopropyl-4-Methyl-6-(2-(4-Methylpiperazin-1-yl)-2-oxoethoxy)thieno[2,3-b]pyridine-2-carboxaMide Property

Boiling point:: 692.4±55.0 °C(Predicted)
Density: 1.46±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≥21.9 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
form: solid
pka: 12.90±0.20(Predicted)
CAS DataBase Reference: 886047-22-9

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 26373
Product name: LY2119620
Packaging: 1mg
Price: $73
Updated: 2024/03/01

Cayman Chemical

Product number: 26373
Product name: LY2119620
Packaging: 10mg
Price: $359
Updated: 2024/03/01

Cayman Chemical

Product number: 26373
Product name: LY2119620
Packaging: 5mg
Price: $198
Updated: 2024/03/01

Tocris

Product number: 6964
Product name: LY2119620
Purity: ≥98%(HPLC)
Packaging: 10
Price: $152
Updated: 2021/12/16

Tocris

Product number: 6964
Product name: LY2119620
Purity: ≥98%(HPLC)
Packaging: 50
Price: $642
Updated: 2021/12/16

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3-aMino-5-chloro-N-cyclopropyl-4-Methyl-6-(2-(4-Methylpiperazin-1-yl)-2-oxoethoxy)thieno[2,3-b]pyridine-2-carboxaMide Chemical Properties,Usage,Production

Description

LY2119620 is a positive allosteric modulator of the M₂ and M₄ muscarinic acetylcholine receptors (mAChRs). It binds to allosteric sites on M₂ and M₄ receptors with K_B values ranging from 1.8 to 3.4 μM. LY2119620 potentiates the activity of the AChR agonist acetylcholine (ACh; ) and the mAChR agonists iperoxo and oxotremorine M at human recombinant M₂ and M₄ receptors expressed in CHO cell membranes. LY2119620 also exhibits allosteric agonism at M₂ and M₄ receptors (23.2 and 16.8%, respectively, of the maximal ACh response).

Uses

LY 2119620 acts as a novel positive allosteric modulator in the treatment of schizophrenia acting as an anti-psychotic agent.

storage

Store at -20°C

References

[1]. croy ch, schober da, xiao h, et al. characterization of the novel positive allosteric modulator, ly2119620, at the muscarinic m(2) and m(4) receptors. mol pharmacol, 2014, 86(1): 106-115. kruse ac, ring am, manglik a, et al. activation and allosteric modulation of a muscarinic acetylcholine receptor. nature, 2013, 504(7478): 101-106.schober da, croy ch, xiao h, et al. development of a radioligand, [(3)h]ly2119620, to probe the human m(2) and m(4) muscarinic receptor allosteric binding sites. mol pharmacol, 2014, 86(1): 116-123.

3-aMino-5-chloro-N-cyclopropyl-4-Methyl-6-(2-(4-Methylpiperazin-1-yl)-2-oxoethoxy)thieno[2,3-b]pyridine-2-carboxaMide Preparation Products And Raw materials

Raw materials

Preparation Products

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3-aMino-5-chloro-N-cyclopropyl-4-Methyl-6-(2-(4-Methylpiperazin-1-yl)-2-oxoethoxy)thieno[2,3-b]pyridine-2-carboxaMide Suppliers

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886047-22-9, 3-aMino-5-chloro-N-cyclopropyl-4-Methyl-6-(2-(4-Methylpiperazin-1-yl)-2-oxoethoxy)thieno[2,3-b]pyridine-2-carboxaMideRelated Search:

Bortezomib 42-(Dimethylphosphinate)rapamycin 17-DMAG Temozolomide GDC-0879 Rapamycin

3-aMino-5-chloro-N-cyclopropyl-4-Methyl-6-(2-(4-Methylpiperazin-1-yl)-2-oxoethoxy)thieno[2,3-b]pyridine-2-carboxaMide

3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methyl-1-piperazinyl)-2-oxoethoxy]-thieno[2,3-b]pyridine-2-carboxamide

LY2119620

CS-2803

Thieno[2,3-b]pyridine-2-carboxamide,3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methyl-1-piperazinyl)-2-oxoethoxy]-

3-aMino-5-chloro-N-cyclopropyl-4-Methyl-6-(2-(4-Methylpiperazin-1-yl)-2-oxoethoxy)thieno[2,3-b]pyridine-2-carboxaMide USP/EP/BP

Muscarinic acetylcholine receptor,Inhibitor,inhibit,mAChR,LY-2119620,LY 2119620,LY2119620

886047-22-9

Inhibitors