ChemicalBook > CAS DataBase List > (OC-6-44)-Tricarbonylchloro(glycinato)ruthenium

(OC-6-44)-Tricarbonylchloro(glycinato)ruthenium

Product Name: (OC-6-44)-Tricarbonylchloro(glycinato)ruthenium
CAS No.: 475473-26-8
Chemical Name: (OC-6-44)-Tricarbonylchloro(glycinato)ruthenium
Synonyms: CORM-3;CORM-3, 10 mM in DMSO;Carbon monoxide releasing molecule 3;Tricarbonylchloro(glycinato)ruthenium;Tricarbonylchloro(glycinato)ruthenium (II);(OC-6-44)-Tricarbonylchloro(glycinato)ruthenium;(OC-6-44)-Tricarbonylchloro(glycinato-κN,κO)ruthenium;Ruthenium, tricarbonylchloro(glycinato-κN,κO)-, (OC-6-44)-;inhibit,Inhibitor,Nuclear factor-kappaB,Nuclear factor-κB,CORM 3,CORM-3,NF-κB,NOD-like Receptor (NLR)
CBNumber: CB12717709
Molecular Formula: C5H3ClNO5Ru
Formula Weight: 293.6
MOL File: 475473-26-8.mol

Less

(OC-6-44)-Tricarbonylchloro(glycinato)ruthenium Property

storage temp.: -20°C
solubility: H2O: soluble20mg/mL, clear
form: powder
color: light yellow to dark yellow
Water Solubility: Soluble to 100 mM in water

Less

Safety

WGK Germany: 3

Less

Hazard and Precautionary Statements (GHS)

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0496
Product name: CORM-3
Packaging: 10mg
Price: $126
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML0496
Product name: CORM-3
Packaging: 50mg
Price: $510
Updated: 2025/07/31

Tocris

Product number: 5320
Product name: CORM3
Packaging: 50
Price: $357
Updated: 2021/12/16

Usbiological

Product number: 255030
Product name: CORM 3
Packaging: 10mg
Price: $333
Updated: 2021/12/16

TRC

Product number: C724813
Product name: CORM3
Packaging: 25mg
Price: $695
Updated: 2021/12/16

Less

(OC-6-44)-Tricarbonylchloro(glycinato)ruthenium Chemical Properties,Usage,Production

Uses

CORM-3 (carbon monoxide (CO) releasing molecule-3) has been used to study its effect on NLRP3 (leucine-rich-repeat-containing receptor, pyrin-domain-containing 3) inflammasome activation via glycolysis in macrophages and also on hyperglycemia-induced IL-1β (interleukin-1 β) production. It has also been used to study its protective function against H₂O₂-induced apoptosis using primary rabbit lens epithelial cells.

Biochem/physiol Actions

CORM-3 is a water-soluble carbon monoxide (CO) releasing molecule that can be used to study the effects of CO on cellular systems. Carbon monoxide (CO), produced during the degradation of heme by the enzyme heme oxygenase, has recently been found to be an important gaseous signaling mediator in mammalian cells CORM-3 has been shown to have anti-inflammatory and cardioprotective activity.

in vivo

CORM-3 (4 mg/kg, ip) reduces NLRP3 inflammasome activation and inhibits hyperglycemia-induced inflammation in mice^[2].

Animal Model:	WT mice (C57BL/6J male, 8e10 weeks old)^[2].
Dosage:	4 mg/kg.
Administration:	IP for 3 h before i.p. injection of E. coli LPS (10 mg/kg), and IP injection after 7-day-treatment of S0130.
Result:	Resulted in significantly lower plasma levels of IL-1β and IL-18 in response to LPS challenge in vivo in WT mice relative to that in vehicle-treated control mice, whereas TNF-a levels were unchanged. Had lower expression of cleaved caspase-1 and cleaved IL-1b in response to ATP and nigericin, relative to vehicle control, whereas the expression of procaspase-1 and pro-IL-1β expression was unchanged.

IC 50

NLRP3

storage

Store at -20°C

(OC-6-44)-Tricarbonylchloro(glycinato)ruthenium Preparation Products And Raw materials

Raw materials

Preparation Products

Less

(OC-6-44)-Tricarbonylchloro(glycinato)ruthenium Suppliers

China 71 India 1 United Kingdom 1 United States 11 Global 84

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4720
Advantage: 55

Shanghai Macklin Biochemical Co.,Ltd.

Tel: 15221275939
Fax: 021-50706099
Email: shenlinxing@macklin.cn
Country: China
ProdList: 15873
Advantage: 55

AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
ProdList: 2990
Advantage: 60

Hubei Jusheng Technology Co.,Ltd

Tel: 027-59599241 18871490274
Fax: 027-59599241
Email: 1400878000@qq.com
Country: China
ProdList: 9858
Advantage: 58

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51395
Advantage: 80

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 8011
Advantage: 55

Rhawn Reagent

Tel: 400-400-1332688 18019345275
Fax: 400-133-2688
Email: amy@rhawn.cn
Country: China
ProdList: 14948
Advantage: 58

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400-6387771-6039 18920764717
Email: sales@heowns.com
Country: China
ProdList: 23771
Advantage: 60

3A Chemicals

Tel: 400-668-9898
Fax: 010-51582189
Email: service@3achem.com
Country: China
ProdList: 20557
Advantage: 58

Guangzhou Tomums Life Science Co., Ltd.

Tel: 020-31155029 18902330969
Fax: 020-31155029
Email: sales@tomums.cn
Country: China
ProdList: 4696
Advantage: 58

Henan Alpha Chemical Co., Ltd.

Tel: 0371-55055611 18137792234
Fax: QQ：3002694073
Email: 3002694073@qq.com
Country: China
ProdList: 9987
Advantage: 58

Career Henan Chemica Co

Tel: +86-0371-86658258 +8613203830695
Fax: 0371-86658258
Email: laboratory@coreychem.com
Country: China
ProdList: 30229
Advantage: 58

Jinan Ruisi Pharmaceutical Technology Co., LTD

Tel: 0531-0531-69900633 19963472814
Email: changyuan20@163.com
Country: China
ProdList: 2742
Advantage: 58

Absin Bioscience Inc.

Tel: 021-38015121 18438616290
Email: lanwu@univ-bio.com
Country: China
ProdList: 24731
Advantage: 58

Shanghai hongqu biomedical technology co. LTD

Tel: 88888888888
Email: hongquchem@qq.com
Country: China
ProdList: 5132
Advantage: 58

Wuhan Yanzhe Technology Co., Ltd

Tel: 15527250409
Fax: QQ：2692360204
Email: wenhaotian12@163.com
Country: China
ProdList: 4171
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

Nantong Hi-Future Biotechnology Co., Ltd

Tel: 18051384581
Email: sales@chemhifuture.com
Country: China
ProdList: 2998
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29757
Advantage: 58

Rhawn Reagent

Tel: 400-1332688 18019345275
Fax: 400-133-2688
Email: amy@rhawn.cn
Country: China
ProdList: 1438
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 59936
Advantage: 58

Kaifeng Mingren Pharmaceutical Co.,LTD

Tel: 0371-65741762
Fax: QQ：2860768577
Email: sales@hasunny.com
Country: China
ProdList: 2380
Advantage: 58

InvivoChem

Tel: 13549236410
Email: sales@invivochem.cn
Country: China
ProdList: 6753
Advantage: 58

CHO Chemical Materials Chang Zhou CO., LTD

Tel: 15995034354
Email: purchase@chochem.cn
Country: China
ProdList: 2704
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Aikon International Limited

Tel: 025-58859352 18921922613
Email: hywu@aikonchem.com
Country: China
ProdList: 10709
Advantage: 58

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 18621169109
Email: market03@meryer.com
Country: China
ProdList: 27987
Advantage: 58

Aobolihui

Tel: 0917-18691729 18691729963
Email: 2553382659@qq.com
Country: China
ProdList: 4739
Advantage: 58

Baoji Funuokang Industrial Co., Ltd

Tel: 0917-3236817 13220096790
Email: 1754423088@qq.com
Country: China
ProdList: 2698
Advantage: 58

Baoji Didu Pharmaceutical and Chemical Co., Ltd

Tel: 029-81145305 17791533577
Email: 1021@dideu.com
Country: China
ProdList: 10009
Advantage: 58

Shanghai Aladdin Biochemical Technology Co.,Ltd.

Tel: 400-6206333 13167063860
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 48457
Advantage: 58

RD International Technology Co., Limited

Tel: 18024082417
Email: market@ubiochem.com
Country: China
ProdList: 9835
Advantage: 58

R&D Systems, Inc

Tel: 18003437475
Fax: 1-612-656-4400
Email: rdname@qq.com
Country: China
ProdList: 6960
Advantage: 58

Sangon Biotech (Shanghai) Co.,Ltd.

Tel: 400-821-026
Email: Sales@sangon.com
Country: China
ProdList: 6710
Advantage: 58

Merck KGaA

Tel: 21-20338288
Email: ordercn@merckgroup.com
Country: China
ProdList: 6394
Advantage: 58

Biosynth Biological Technology (Suzhou) Co Ltd

Tel: 51288865780
Email: sales@biosynth.com
Country: China
ProdList: 6051
Advantage: 58

Adooq Bioscience LLC

Tel: 400-025-6535
Email: sales@adooq.cn
Country: China
ProdList: 6215
Advantage: 58

Selleck Chemicals

Tel: 400-668-6834
Email: info@selleck.cn
Country: China
ProdList: 6071
Advantage: 58

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Tel: +86-13017695106 +86-13676922317
Email: jiuyitime@fdachem.com
Country: China
ProdList: 16513
Advantage: 58

SHANGHAI KEAN TECHNOLOGY CO., LTD.

Tel: +8613817748580
Fax: 021-50175322
Email: cooperation@kean-chem.com
Country: China
ProdList: 40066
Advantage: 58

Nantong HI-FUTURE Biology Co., Ltd.

Tel: +undefined18051384581
Email: sales@chemhifuture.com
Country: China
ProdList: 3135
Advantage: 58

Beijing Boning Biotechnology Co., Ltd.

Tel: 13269979963
Email: 1565439254@qq.com
Country: CHINA
ProdList: 195
Advantage: 58

Foshan Minghua Biotechnology Co., Ltd.

Tel: 18312287787
Country: CHINA
ProdList: 196
Advantage: 58

Jinan Lemon Biotechnology Co., Ltd.

Tel: 138000000
Email: geans@163.com
Country: China
ProdList: 155
Advantage: 58

Guangzhou Weiyu Biotechnology Co., Ltd.

Tel: 18218437607
Country: CHINA
ProdList: 178
Advantage: 58

Tianjin Baibei Biotechnology Co., Ltd.

Tel: 15302170631
Country: CHINA
ProdList: 166
Advantage: 58

Guangzhou Tuoshan Biotechnology Co., Ltd.

Tel: 19928332050
Country: CHINA
ProdList: 161
Advantage: 58

Less

View Lastest Price from (OC-6-44)-Tricarbonylchloro(glycinato)ruthenium manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: CORM-3 475473-26-8
Price: US $2.00-5.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-07-08

475473-26-8, (OC-6-44)-Tricarbonylchloro(glycinato)rutheniumRelated Search:

(OC-6-44)-Tricarbonylchloro(glycinato)ruthenium

CORM-3

Ruthenium, tricarbonylchloro(glycinato-κN,κO)-, (OC-6-44)-

Carbon monoxide releasing molecule 3

Tricarbonylchloro(glycinato)ruthenium (II)

Tricarbonylchloro(glycinato)ruthenium

inhibit,Inhibitor,Nuclear factor-kappaB,Nuclear factor-κB,CORM 3,CORM-3,NF-κB,NOD-like Receptor (NLR)

(OC-6-44)-Tricarbonylchloro(glycinato-κN,κO)ruthenium

CORM-3, 10 mM in DMSO

475473-26-8

C5H4ClNO5Ru

Inhibitors