ChemicalBook > CAS DataBase List > 4-(4-MethoxybenzylaMino)-5-ethoxycarbonyl-2-MethylthiopyriMidine

4-(4-MethoxybenzylaMino)-5-ethoxycarbonyl-2-MethylthiopyriMidine

Product Name: 4-(4-MethoxybenzylaMino)-5-ethoxycarbonyl-2-MethylthiopyriMidine
CAS No.: 211230-35-2
Chemical Name: 4-(4-MethoxybenzylaMino)-5-ethoxycarbonyl-2-MethylthiopyriMidine
Synonyms: AvafilImpurity30;4-(4-MethoxybenzylaMino)-5-ethoxycarbonyl-2-MethylthiopyriMidine;4-(4-Methoxybenzylamino)-2-methanethiopyrimidine-5-carboxylic Acid Ethyl Ester;4-(4-Methoxy-benzylamino)-2-methylsulfanyl-pyrimidine-5-carboxylic acid ethyl ester;4-(4-methoxybenzylamino)-2-methanesulfanyl-pyrimidine-5-carboxylic acid ethyl ester;5-Pyrimidinecarboxylic acid, 4-[[(4-methoxyphenyl)methyl]amino]-2-(methylthio)-, ethyl ester
CBNumber: CB12721078
Molecular Formula: C16H19N3O3S
Formula Weight: 333.41
MOL File: 211230-35-2.mol

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4-(4-MethoxybenzylaMino)-5-ethoxycarbonyl-2-MethylthiopyriMidine Property

Boiling point:: 493.6±35.0 °C(Predicted)
Density: 1.26±0.1 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
pka: 2.81±0.10(Predicted)
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

AK Scientific

Product number: 8992CD
Product name: Ethyl4-((4-methoxybenzyl)amino)-2-(methylthio)pyrimidine-5-carboxylate
Packaging: 100mg
Price: $207
Updated: 2021/12/16

AK Scientific

Product number: 8992CD
Product name: Ethyl4-((4-methoxybenzyl)amino)-2-(methylthio)pyrimidine-5-carboxylate
Packaging: 250mg
Price: $242
Updated: 2021/12/16

AK Scientific

Product number: 8992CD
Product name: Ethyl4-((4-methoxybenzyl)amino)-2-(methylthio)pyrimidine-5-carboxylate
Packaging: 1g
Price: $409
Updated: 2021/12/16

AK Scientific

Product number: 8992CD
Product name: Ethyl4-((4-methoxybenzyl)amino)-2-(methylthio)pyrimidine-5-carboxylate
Packaging: 5g
Price: $1002
Updated: 2021/12/16

Ambeed

Product number: A659647
Product name: Ethyl4-((4-methoxybenzyl)amino)-2-(methylthio)pyrimidine-5-carboxylate
Purity: 95+%
Packaging: 100mg
Price: $24
Updated: 2021/12/16

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4-(4-MethoxybenzylaMino)-5-ethoxycarbonyl-2-MethylthiopyriMidine Chemical Properties,Usage,Production

Uses

4-(4-Methoxybenzylamino)-2-methanethiopyrimidine-5-carboxylic Acid Ethyl Ester is used in the preparation of pyrimidine derivatives for the treatment of metabolic bone disease.

Synthesis

5909-24-0

2393-23-9

211230-35-2

Example 14: Synthesis of ethyl 4-[[(4-methoxyphenyl)methyl]amino]-2-methylthio-5-pyrimidinecarboxylate To a 60 mL solution of tetrahydrofuran containing ethyl 4-chloro-2-methylthiopyrimidine-5-carboxylate (6.05 g, 26.07 mmol) was sequentially added triethylamine (11 mL, 79.5 mmol) and 4-methoxybenzylamine (3.6 mL, 27.6 mmol) at room temperature. The reaction mixture was stirred for 1 h. The reaction solution was filtered and the resulting white solid was washed with ethyl acetate. The filtrate and washings were combined and concentrated under reduced pressure. The residue was partitioned between chloroform and saturated aqueous sodium bicarbonate. The organic layer was separated, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give ethyl 4-[[(4-methoxyphenyl)methyl]amino]-2-methylthio-5-pyrimidinecarboxylate (7.60 g, 88% yield) with a melting point of 72-74 °C. Elemental analysis: C16H19N3O3S Calculated values: c, 57.64; h, 5.74; n, 12.60. Measured values: C, 57.65; H, 5.80; N, 12.57.

References

[1] Patent: US2004/224958, 2004, A1
[2] Patent: US6498163, 2002, B1
[3] Patent: WO2015/92431, 2015, A1. Location in patent: Page/Page column 94; 95

4-(4-MethoxybenzylaMino)-5-ethoxycarbonyl-2-MethylthiopyriMidine Preparation Products And Raw materials

Raw materials

Preparation Products

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211230-35-2, 4-(4-MethoxybenzylaMino)-5-ethoxycarbonyl-2-MethylthiopyriMidineRelated Search:

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