ChemicalBook > CAS DataBase List > GLPG-0778

GLPG-0778

Product Name
GLPG-0778
CAS No.
1206163-45-2
Chemical Name
GLPG-0778
Synonyms
CS-2178;G 154578;GLPG-0778;Solcitinib;GSK 2586184;GSK 2586184A;GLPG 0778;GLPG-0778;GLPG0778, GSK2586184;Solcitinib（GLPG0778）;Solcitinib (GSK2586184)
CBNumber
CB12725627
Molecular Formula
C22H23N5O2
Formula Weight
389.45
MOL File
1206163-45-2.mol
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GLPG-0778 Property

Density 
1.40±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 2 mg/ml; DMSO: 5 mg/ml; Ethanol: 1 mg/ml
form 
A crystalline solid
pka
7.99±0.20(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
23439
Product name
Solcitinib
Purity
≥98%
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
23439
Product name
Solcitinib
Purity
≥98%
Packaging
5mg
Price
$161
Updated
2024/03/01
Cayman Chemical
Product number
23439
Product name
Solcitinib
Purity
≥98%
Packaging
10mg
Price
$283
Updated
2024/03/01
Cayman Chemical
Product number
23439
Product name
Solcitinib
Purity
≥98%
Packaging
25mg
Price
$618
Updated
2024/03/01
ChemScene
Product number
CS-5204
Product name
Solcitinib
Purity
99.59%
Packaging
5mg
Price
$90
Updated
2021/12/16
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GLPG-0778 Chemical Properties,Usage,Production

Description

Solcitinib is a JAK1 inhibitor (IC50 = 9.8 nM). It is greater than 10-fold selective for JAK1 over JAK2, JAK3, and TYK2.

Uses

Solcitinib is an orally active, competitive, potent, selective JAK1 inhibitor, with an IC50 of 9.8 nM, and 11-, 55- and 23-fold selectivity over JAK2, JAK3 and TYK2, respectively; Solcitinib is used in the research of moderate-to-severe plaque-type psoriasis.

IC 50

JAK1: 9.8 nM (IC50)

References

[1] Ludbrook VJ, et al. Investigation of selective JAK1 inhibitor GSK2586184 for the treatment of psoriasis in a randomized placebo-controlled phase IIa study. Br J Dermatol. 2016 May;174(5):985-95. DOI:10.1111/bjd.14399

GLPG-0778 Preparation Products And Raw materials

Raw materials

Preparation Products

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GLPG-0778 Suppliers

China 76 India 1 United Kingdom 1 United States 9 Global 87
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58

1206163-45-2, GLPG-0778Related Search:


  • GLPG-0778
  • Solcitinib
  • N-(5-(4-(3,3-Dimethylazetidine-1-carbonyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide
  • Solcitinib (GSK2586184)
  • G 154578
  • GSK 2586184
  • GSK 2586184A
  • Solcitinib(GLPG0778,GSK2586184)
  • CS-2178
  • GLPG 0778;GLPG-0778
  • Solcitinib - GSK 2586184 | GLPG 0778
  • GLPG 0778;GSK 2586184;GLPG-0778;GSK-2586184
  • GLPG0778, GSK2586184
  • Cyclopropanecarboxamide, N-[5-[4-[(3,3-dimethyl-1-azetidinyl)carbonyl]phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl]-
  • Solcitinib（GLPG0778）
  • GSK 2586184,GLPG 0778,Janus kinase,Inhibitor,Solcitinib,inhibit,GSK2586184,JAK,GLPG0778
  • Solcitinib, 10 mM in DMSO
  • 1206163-45-2
  • API