(S)-tert-butyl 2-(5-(4-broMophenyl)-1h-iMidazol-2-yl)pyrrolidine-1-carboxylate

Product Name: (S)-tert-butyl 2-(5-(4-broMophenyl)-1h-iMidazol-2-yl)pyrrolidine-1-carboxylate
CAS No.: 1007881-98-2
Chemical Name: (S)-tert-butyl 2-(5-(4-broMophenyl)-1h-iMidazol-2-yl)pyrrolidine-1-carboxylate
Synonyms: (S)-tert-butyl 2-(2-(4-bromophenyl)-2-oxoethylcarbamoyl)pyrr...;(S)-tert-butyl 2-(2-(4-bromophenyl)-2-oxoethylcarbamoyl)pyrrolidine-1-carboxylate;tert-Butyl (S)-2-((2-(4-bromophenyl)-2-oxoethyl)carbamoyl)pyrrolidine-1-carboxylate;tert-butyl (2S)-2-[[2-(4-bromophenyl)-2-oxoethyl]carbamoyl]pyrrolidine-1-carboxylate;(S)-2-[2-(4-Bromo-phenyl)-2-oxo-ethylcarbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester;1-Pyrrolidinecarboxylic acid, 2-[[[2-(4-bromophenyl)-2-oxoethyl]amino]carbonyl]-, 1,1-dimethylethyl ester, (2S)-
CBNumber: CB12727823
Molecular Formula: C18H23BrN2O4
Formula Weight: 411.29
MOL File: 1007881-98-2.mol

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(S)-tert-butyl 2-(5-(4-broMophenyl)-1h-iMidazol-2-yl)pyrrolidine-1-carboxylate Property

storage temp.: 2-8°C

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Ambeed

Product number: A779618
Product name: (S)-tert-Butyl2-((2-(4-bromophenyl)-2-oxoethyl)carbamoyl)pyrrolidine-1-carboxylate
Purity: 95+%
Packaging: 250mg
Price: $40
Updated: 2021/12/16

Chemenu

Product number: CM133421
Product name: tert-butyl(S)-2-((2-(4-bromophenyl)-2-oxoethyl)carbamoyl)pyrrolidine-1-carboxylate
Purity: 95%
Packaging: 1g
Price: $204
Updated: 2021/12/16

Ambeed

Product number: A779618
Product name: (S)-tert-Butyl2-((2-(4-bromophenyl)-2-oxoethyl)carbamoyl)pyrrolidine-1-carboxylate
Purity: 95+%
Packaging: 1g
Price: $269
Updated: 2021/12/16

Ambeed

Product number: A779618
Product name: (S)-tert-Butyl2-((2-(4-bromophenyl)-2-oxoethyl)carbamoyl)pyrrolidine-1-carboxylate
Purity: 95+%
Packaging: 5g
Price: $269
Updated: 2021/12/16

Chemenu

Product number: CM133421
Product name: tert-butyl(S)-2-((2-(4-bromophenyl)-2-oxoethyl)carbamoyl)pyrrolidine-1-carboxylate
Purity: 95%
Packaging: 5g
Price: $561
Updated: 2021/12/16

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(S)-tert-butyl 2-(5-(4-broMophenyl)-1h-iMidazol-2-yl)pyrrolidine-1-carboxylate Chemical Properties,Usage,Production

Synthesis

15761-39-4

7644-04-4

1007881-98-2

General procedure for the synthesis of tert-butyl (S)-2-((2-(4-bromophenyl)-2-oxoethyl)carbamoyl)pyrrolidine-1-carboxylate from BOC-L-proline and 2-amino-4'-bromoacetophenone: in dry DMF (600 mL), 2-amino-1-(4-bromophenyl)acetophenone (50 g, 0.2 mol), BOC-L -proline (43.0 g, 0.2 mol), HATU (53 g, 0.21 mol) and N,N-diisopropylethylamine (80.0 g, 0.62 mol). The reaction mixture was stirred at 5 °C for 1 hour. After completion of the reaction, most of the DMF was removed by distillation under reduced pressure, and the residue was dissolved in ethyl acetate (600 mL) and washed sequentially with saturated aqueous NaHCO3 solution (500 mL) and brine (500 mL). The organic layer was dried over anhydrous MgSO4, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography with the eluent of petroleum ether/ethyl acetate (3:1 to 1:1) to afford the light yellow solid intermediate I-11 (60 g, 62% yield).1H NMR (400 MHz, CDCl3) δ: 7.85 (d, J = 8.4 Hz, 2H), 7.66 (d, J = 8.4 Hz, 2H), 4.67-4.80 ( m, 2H), 4.33-4.41 (m, 1H), 3.42-3.53 (m, 2H), 2.19-2.31 (m, 2H), 1.90-2.00 (m, 2H), 1.50 (s, 9H), 1.10.

References

[1] Patent: WO2011/15657, 2011, A1. Location in patent: Page/Page column 20
[2] Patent: WO2011/54834, 2011, A1. Location in patent: Page/Page column 31-32
[3] Patent: US2012/136027, 2012, A1. Location in patent: Page/Page column 9
[4] Journal of Medicinal Chemistry, 2014, vol. 57, # 5, p. 2058 - 2073

(S)-tert-butyl 2-(5-(4-broMophenyl)-1h-iMidazol-2-yl)pyrrolidine-1-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-tert-butyl 2-(5-(4-broMophenyl)-1h-iMidazol-2-yl)pyrrolidine-1-carboxylate Suppliers

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View Lastest Price from (S)-tert-butyl 2-(5-(4-broMophenyl)-1h-iMidazol-2-yl)pyrrolidine-1-carboxylate manufacturers

Career Henan Chemical Co

Product: (S)-tert-butyl 2-(5-(4-broMophenyl)-1h-iMidazol-2-yl)pyrrolidine-1-carboxylate 1007881-98-2
Price: US $3.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-08-06

1007881-98-2, (S)-tert-butyl 2-(5-(4-broMophenyl)-1h-iMidazol-2-yl)pyrrolidine-1-carboxylateRelated Search:

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tert-Butyl (S)-2-((2-(4-bromophenyl)-2-oxoethyl)carbamoyl)pyrrolidine-1-carboxylate

(S)-tert-butyl 2-(2-(4-bromophenyl)-2-oxoethylcarbamoyl)pyrr...

(S)-2-[2-(4-Bromo-phenyl)-2-oxo-ethylcarbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

1007881-98-2