TZ-9

Product Name: TZ-9
CAS No.: 1002789-86-7
Chemical Name: TZ-9
Synonyms: TZ9;TZ-9;B4861;SMI# 9;CS-3536;TZ9,TZ-9;TZ9, 10 mM in DMSO;Rad6 Inhibitor, TZ9;(4-Amino-6-(phenylamino)-1,3,5-triazin-2-yl)methyl 4-nitrobenzoate;1,3,5-Triazine-2-methanol, 4-amino-6-(phenylamino)-, 2-(4-nitrobenzoate)
CBNumber: CB12729377
Molecular Formula: C17H14N6O4
Formula Weight: 366.34
MOL File: 1002789-86-7.mol

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TZ-9 Property

Boiling point:: 675.9±65.0 °C(Predicted)
Density: 1.477±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml
pka: 3.69±0.10(Predicted)
form: Powder
color: Light yellow to yellow
InChI: 1S/C17H14N6O4/c18-16-20-14(21-17(22-16)19-12-4-2-1-3-5-12)10-27-15(24)11-6-8-13(9-7-11)23(25)26/h1-9H,10H2,(H3,18,19,20,21,22)
InChIKey: RRRDZFQRNJTKHL-UHFFFAOYSA-N
SMILES: C1=CC=C(C=C1)NC2=NC(=NC(=N2)N)COC(=O)C3=CC=C(C=C3)[N+](=O)[O-]

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Safety

WGK Germany: WGK 2
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 15964
Product name: TZ9
Purity: ≥98%
Packaging: 1mg
Price: $34
Updated: 2024/03/01

Cayman Chemical

Product number: 15964
Product name: TZ9
Purity: ≥98%
Packaging: 5mg
Price: $150
Updated: 2024/03/01

Cayman Chemical

Product number: 15964
Product name: TZ9
Purity: ≥98%
Packaging: 10mg
Price: $264
Updated: 2024/03/01

Cayman Chemical

Product number: 15964
Product name: TZ9
Purity: ≥98%
Packaging: 25mg
Price: $438
Updated: 2021/12/16

TRC

Product number: T966395
Product name: SMI#9
Packaging: 1mg
Price: $90
Updated: 2021/12/16

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TZ-9 Chemical Properties,Usage,Production

Uses

TZ9 is a selective Rad6 inhibitor. TZ9 inhibits Rad6B-induced histone H2A ubiquitination, downregulates intracellular β-catenin, induces G2-M arrest and apoptosis, and inhibits the proliferation and migration of metastatic human breast cancer cells[1].

Biological Activity

Cell permeable: yes', 'Primary Target
Rad6B/HHR6B', 'Reversible: yes

References

[1] Sanders MA, et al. Novel inhibitors of Rad6 ubiquitin conjugating enzyme: design, synthesis, identification, and functional characterization. Mol Cancer Ther. 2013 Apr;12(4):373-83. DOI:10.1158/1535-7163.MCT-12-0793

TZ-9 Preparation Products And Raw materials

Raw materials

Preparation Products

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TZ-9 Suppliers

China 49 United States 5 Global 54

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
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Guangzhou QiYun Biotechnology Co., Ltd.

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Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
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Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
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Shanghai Rechem science Co., Ltd.

Tel: 021-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
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Amadis Chemical Company Limited

Tel: 571-89925085
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Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Musechem

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Twochem Co.Ltd.

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Tianjin Kaifu Pharmaceutical Technology Co., Ltd.

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TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
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1002789-86-7, TZ-9Related Search:

TZ9

TZ-9

B4861

CS-3536

1,3,5-Triazine-2-methanol, 4-amino-6-(phenylamino)-, 2-(4-nitrobenzoate)

SMI# 9

TZ9,TZ-9

(4-Amino-6-(phenylamino)-1,3,5-triazin-2-yl)methyl 4-nitrobenzoate

TZ9, 10 mM in DMSO

Rad6 Inhibitor, TZ9

1002789-86-7