6-AMino-2-chloronicotinonitrile
- Product Name
- 6-AMino-2-chloronicotinonitrile
- CAS No.
- 53554-20-4
- Chemical Name
- 6-AMino-2-chloronicotinonitrile
- Synonyms
- 6-AMino-2-chloronicotinonitrile;6-Amino-2-chloro-3-pyridinecarbonitrile;6-amino-2-chloropyridine-3-carbonitrile;3-Pyridinecarbonitrile, 6-amino-2-chloro-
- CBNumber
- CB12734113
- Molecular Formula
- C6H4ClN3
- Formula Weight
- 153.57
- MOL File
- 53554-20-4.mol
6-AMino-2-chloronicotinonitrile Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- 3411DA
- Product name
- 6-Amino-2-chloronicotinonitrile
- Packaging
- 250mg
- Price
- $477
- Updated
- 2021/12/16
- Product number
- CM177457
- Product name
- 6-amino-2-chloronicotinonitrile
- Purity
- 95%
- Packaging
- 1g
- Price
- $636
- Updated
- 2021/12/16
- Product number
- CD11109196
- Product name
- 6-Amino-2-chloronicotinonitrile
- Purity
- 95+%
- Packaging
- 1g
- Price
- $673
- Updated
- 2021/12/16
- Product number
- A167074
- Product name
- 6-Amino-2-chloronicotinonitrile
- Purity
- 95%
- Packaging
- 1g
- Price
- $782
- Updated
- 2021/12/16
- Product number
- 53554204
- Product name
- 6-Amino-2-chloronicotinonitrile
- Packaging
- 1g
- Price
- $919
- Updated
- 2021/12/16
6-AMino-2-chloronicotinonitrile Chemical Properties,Usage,Production
Synthesis
557-21-1
1221398-11-3
53554-20-4
6-Chloro-5-iodopyridin-2-amine (4.00 g, 15.7 mmol) and zinc cyanide (0.997 g, 8.50 mmol) were dissolved in 15 mL of N,N-dimethylformamide under argon protection. Subsequently, zinc cyanide was added, and the mixture was vigorously stirred and purged with a stream of argon for 5 min. Next, tris(dibenzylideneacetone)dipalladium(0) (0.642 g, 0.701 mmol) and 1,1'-bis(diphenylphosphino)ferrocene (0.784 g, 1.42 mmol) were added, and the reaction mixture was stirred for 10 min at 120 °C. After completion of the reaction, it was extracted with ethyl acetate and aqueous half-saturated sodium bicarbonate, and the organic phase was concentrated by filtration through silica gel. Finally, purification by silica gel column chromatography (elution gradient: cyclohexane/ethyl acetate 100/0→50/50) afforded the target product 6-amino-2-chlorocyanopyridine in a yield of 1.60 g and 66%. Mass spectrum (ESI+): m/z = 154 [M + H]+.
References
[1] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 5, p. 1697 - 1700
[2] Patent: US2018/37594, 2018, A1. Location in patent: Paragraph 0344-0347
[3] European Journal of Medicinal Chemistry, 2014, vol. 84, p. 404 - 416
6-AMino-2-chloronicotinonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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