OF-1

Product Name: OF-1
CAS No.: 919973-83-4
Chemical Name: OF-1
Synonyms: OF-1;CS-1634;OF-1;OF1;OF-1 USP/EP/BP;OF-1, 10 mM in DMSO;Inhibitor,inhibit,OF1,Epigenetic Reader Domain,OF 1,OF-1;4-bromo-N-(6-methoxy-1,3-dimethyl-2-oxobenzimidazol-5-yl)-2-methylbenzenesulfonamide;4-Bromo-N-(2,3-dihydro-6-methoxy-1,3-dimethyl-2-oxo-1H-benzimidazol-5-yl)-2-methyl-benzenesulfonamide;Benzenesulfonamide, 4-bromo-N-(2,3-dihydro-6-methoxy-1,3-dimethyl-2-oxo-1H-benzimidazol-5-yl)-2-methyl-;4-bromo-N-(6-methoxy-1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-2-methylbenzenesulfonamide
CBNumber: CB12735529
Molecular Formula: C17H18BrN3O4S
Formula Weight: 440.31
MOL File: 919973-83-4.mol

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OF-1 Property

Boiling point:: 573.8±60.0 °C(Predicted)
Density: 1.557±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble5mg/mL, clear (warmed)
pka: 9.44±0.20(Predicted)
form: powder
color: white to beige

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Safety

Hazard Codes: T,Xi
Risk Statements: 25-36
Safety Statements: 26-45
RIDADR: UN 2811 6.1 / PGIII

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1184
Product name: OF-1
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $146
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1184
Product name: OF-1
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $498
Updated: 2022/05/15

Cayman Chemical

Product number: 17124
Product name: OF-1
Purity: ≥98%
Packaging: 1mg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 17124
Product name: OF-1
Purity: ≥98%
Packaging: 5mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 17124
Product name: OF-1
Purity: ≥98%
Packaging: 10mg
Price: $190
Updated: 2024/03/01

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OF-1 Chemical Properties,Usage,Production

Uses

4-Bromo-N-(2,3-dihydro-6-methoxy-1,3-dimethyl-2-oxo-1H-benzimidazol-5-yl)-2-methylbenzenesulfonamide is a selective BRPF2 bromodomain inhibitor.

Biological Activity

OF-1 is a chemical probe for the bromodomains of the BRPF (BRomodomain and PHD Finger containing) family of scaffolding proteins (BRPF1, BRPF2, BRPF3) th at assemble histone acetyltransferase (HAT) complexes of the MYST family members MOZ and MORF. The BRPF1 protein is the scaffold subunit of the MYST acetyltransferase complex, which plays a crucial roles in DNA repair, recombination and replication as well as transcription activation. OF-1 binds to BRPF1B with a Kd of 100 nM , to BRPF2 with a Kd of 500 nM and to BRPF3 with a Kd of 2.4 mM, and shows >100-fold selectivity against most other bromodomains. The closest off-target effects are against BRD4 (39-fold selectivity) and 50% inhibition of TIF1a at 20 μM. For full characterization details, please see OF-1 on the Structural Genomics Consortium (SGC) website.

To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

storage

Store at +4°C

OF-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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OF-1 Suppliers

China 71 United Kingdom 1 United States 11 Global 83

Hangzhou ChangCun Biotechnology Co., Ltd.

Tel: 0571-; 13567100326
Fax: QQ158848739
Email: 158848739@qq.com
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Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
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Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
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Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4728
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Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
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Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
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YouCoChem (Beijing) Chemical Technology Co., Ltd.

Tel: 18800159827
Email: youcochem@163.com
Country: China
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D&C Chemicals

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Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
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Guangzhou QiYun Biotechnology Co., Ltd.

Tel: 020-61288194 61288195
Fax: 020-61288700
Email: 505721671@qq.com
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919973-83-4, OF-1Related Search:

PFI-2 PFI3 Ribociclib Methotrexate EPZ015666 Foretinib (GSK1363089)

CS-1634

OF-1;OF1

4-bromo-N-(6-methoxy-1,3-dimethyl-2-oxobenzimidazol-5-yl)-2-methylbenzenesulfonamide

OF-1

4-bromo-N-(6-methoxy-1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-2-methylbenzenesulfonamide

4-Bromo-N-(2,3-dihydro-6-methoxy-1,3-dimethyl-2-oxo-1H-benzimidazol-5-yl)-2-methyl-benzenesulfonamide

Benzenesulfonamide, 4-bromo-N-(2,3-dihydro-6-methoxy-1,3-dimethyl-2-oxo-1H-benzimidazol-5-yl)-2-methyl-

OF-1 USP/EP/BP

Inhibitor,inhibit,OF1,Epigenetic Reader Domain,OF 1,OF-1

OF-1, 10 mM in DMSO

919973-83-4

19973-83-4

Inhibitors