OF-1
- Product Name
- OF-1
- CAS No.
- 919973-83-4
- Chemical Name
- OF-1
- Synonyms
- OF-1;CS-1634;OF-1;OF1;OF-1 USP/EP/BP;OF-1, 10 mM in DMSO;Inhibitor,inhibit,OF1,Epigenetic Reader Domain,OF 1,OF-1;4-bromo-N-(6-methoxy-1,3-dimethyl-2-oxobenzimidazol-5-yl)-2-methylbenzenesulfonamide;4-Bromo-N-(2,3-dihydro-6-methoxy-1,3-dimethyl-2-oxo-1H-benzimidazol-5-yl)-2-methyl-benzenesulfonamide;Benzenesulfonamide, 4-bromo-N-(2,3-dihydro-6-methoxy-1,3-dimethyl-2-oxo-1H-benzimidazol-5-yl)-2-methyl-;4-bromo-N-(6-methoxy-1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-2-methylbenzenesulfonamide
- CBNumber
- CB12735529
- Molecular Formula
- C17H18BrN3O4S
- Formula Weight
- 440.31
- MOL File
- 919973-83-4.mol
OF-1 Property
- Boiling point:
- 573.8±60.0 °C(Predicted)
- Density
- 1.557±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble5mg/mL, clear (warmed)
- pka
- 9.44±0.20(Predicted)
- form
- powder
- color
- white to beige
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H319Causes serious eye irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML1184
- Product name
- OF-1
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $146
- Updated
- 2024/03/01
- Product number
- SML1184
- Product name
- OF-1
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $498
- Updated
- 2022/05/15
- Product number
- 17124
- Product name
- OF-1
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $49
- Updated
- 2024/03/01
- Product number
- 17124
- Product name
- OF-1
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $109
- Updated
- 2024/03/01
- Product number
- 17124
- Product name
- OF-1
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $190
- Updated
- 2024/03/01
OF-1 Chemical Properties,Usage,Production
Uses
4-Bromo-N-(2,3-dihydro-6-methoxy-1,3-dimethyl-2-oxo-1H-benzimidazol-5-yl)-2-methylbenzenesulfonamide is a selective BRPF2 bromodomain inhibitor.
Biological Activity
OF-1 is a chemical probe for the bromodomains of the BRPF (BRomodomain and PHD Finger containing) family of scaffolding proteins (BRPF1, BRPF2, BRPF3) th at assemble histone acetyltransferase (HAT) complexes of the MYST family members MOZ and MORF. The BRPF1 protein is the scaffold subunit of the MYST acetyltransferase complex, which plays a crucial roles in DNA repair, recombination and replication as well as transcription activation. OF-1 binds to BRPF1B with a Kd of 100 nM , to BRPF2 with a Kd of 500 nM and to BRPF3 with a Kd of 2.4 mM, and shows >100-fold selectivity against most other bromodomains. The closest off-target effects are against BRD4 (39-fold selectivity) and 50% inhibition of TIF1a at 20 μM. For full characterization details, please see OF-1 on the Structural Genomics Consortium (SGC) website.
To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
storage
Store at +4°C
OF-1 Preparation Products And Raw materials
Raw materials
Preparation Products
OF-1 Suppliers
- Tel
- --
- Fax
- --
- customerservice@tocris.co.uk
- Country
- United Kingdom
- ProdList
- 5726
- Advantage
- 77