OF-1

Product Name: OF-1
CAS No.: 919973-83-4
Chemical Name: OF-1
Synonyms: OF-1;CS-1634;OF-1;OF1;OF-1 USP/EP/BP;OF-1, 10 mM in DMSO;Inhibitor,inhibit,OF1,Epigenetic Reader Domain,OF 1,OF-1;4-bromo-N-(6-methoxy-1,3-dimethyl-2-oxobenzimidazol-5-yl)-2-methylbenzenesulfonamide;4-Bromo-N-(2,3-dihydro-6-methoxy-1,3-dimethyl-2-oxo-1H-benzimidazol-5-yl)-2-methyl-benzenesulfonamide;Benzenesulfonamide, 4-bromo-N-(2,3-dihydro-6-methoxy-1,3-dimethyl-2-oxo-1H-benzimidazol-5-yl)-2-methyl-;4-bromo-N-(6-methoxy-1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-2-methylbenzenesulfonamide
CBNumber: CB12735529
Molecular Formula: C17H18BrN3O4S
Formula Weight: 440.31
MOL File: 919973-83-4.mol

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OF-1 Property

Boiling point:: 573.8±60.0 °C(Predicted)
Density: 1.557±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble5mg/mL, clear (warmed)
pka: 9.44±0.20(Predicted)
form: powder
color: white to beige

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Safety

Hazard Codes: T,Xi
Risk Statements: 25-36
Safety Statements: 26-45
RIDADR: UN 2811 6.1 / PGIII

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1184
Product name: OF-1
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $146
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1184
Product name: OF-1
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $498
Updated: 2022/05/15

Cayman Chemical

Product number: 17124
Product name: OF-1
Purity: ≥98%
Packaging: 1mg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 17124
Product name: OF-1
Purity: ≥98%
Packaging: 5mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 17124
Product name: OF-1
Purity: ≥98%
Packaging: 10mg
Price: $190
Updated: 2024/03/01

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OF-1 Chemical Properties,Usage,Production

Uses

4-Bromo-N-(2,3-dihydro-6-methoxy-1,3-dimethyl-2-oxo-1H-benzimidazol-5-yl)-2-methylbenzenesulfonamide is a selective BRPF2 bromodomain inhibitor.

Biological Activity

OF-1 is a chemical probe for the bromodomains of the BRPF (BRomodomain and PHD Finger containing) family of scaffolding proteins (BRPF1, BRPF2, BRPF3) th at assemble histone acetyltransferase (HAT) complexes of the MYST family members MOZ and MORF. The BRPF1 protein is the scaffold subunit of the MYST acetyltransferase complex, which plays a crucial roles in DNA repair, recombination and replication as well as transcription activation. OF-1 binds to BRPF1B with a Kd of 100 nM , to BRPF2 with a Kd of 500 nM and to BRPF3 with a Kd of 2.4 mM, and shows >100-fold selectivity against most other bromodomains. The closest off-target effects are against BRD4 (39-fold selectivity) and 50% inhibition of TIF1a at 20 μM. For full characterization details, please see OF-1 on the Structural Genomics Consortium (SGC) website.

To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

storage

Store at +4°C

OF-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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OF-1 Suppliers

China 71 United Kingdom 1 United States 11 Global 83

Target molecule Corp.

Tel: 857-239-0968
Fax: 857-239-8801
Email: service1@targetmol.com
Country: United States
ProdList: 2559
Advantage: 60

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32159
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

Aladdin Scientific

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Email: tp@aladdinsci.com
Country: United States
ProdList: 57505
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United States Biological

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ProdList: 6075
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ApexBio Technology

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ProdList: 6251
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Cayman Chemical Company

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MedChemExpress

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Riedel-de Haen AG

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919973-83-4, OF-1Related Search:

PFI-2 PFI3 Ribociclib Methotrexate EPZ015666 Foretinib (GSK1363089)

CS-1634

OF-1;OF1

4-bromo-N-(6-methoxy-1,3-dimethyl-2-oxobenzimidazol-5-yl)-2-methylbenzenesulfonamide

OF-1

4-bromo-N-(6-methoxy-1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-2-methylbenzenesulfonamide

4-Bromo-N-(2,3-dihydro-6-methoxy-1,3-dimethyl-2-oxo-1H-benzimidazol-5-yl)-2-methyl-benzenesulfonamide

Benzenesulfonamide, 4-bromo-N-(2,3-dihydro-6-methoxy-1,3-dimethyl-2-oxo-1H-benzimidazol-5-yl)-2-methyl-

OF-1 USP/EP/BP

Inhibitor,inhibit,OF1,Epigenetic Reader Domain,OF 1,OF-1

OF-1, 10 mM in DMSO

919973-83-4

19973-83-4

Inhibitors