ChemicalBook > CAS DataBase List > AZ-5104

AZ-5104

Product Name
AZ-5104
CAS No.
1421373-98-9
Chemical Name
AZ-5104
Synonyms
AZ5104;AZ7550;AZD5104;AZ-5104;CS-1709;AZ-5104;AZ 5104;AZ5104; AZ-5104;Demethylated AZ9291;metabolite of AZD9291;Osimertinib Impurity A
CBNumber
CB12741564
Molecular Formula
C27H31N7O2
Formula Weight
485.58
MOL File
1421373-98-9.mol
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AZ-5104 Property

Melting point:
158 - 160°C
Density 
1.267±0.06 g/cm3(Predicted)
storage temp. 
Refrigerator
solubility 
Chloroform (Slightly), Methanol (Slightly)
pka
12.68±0.70(Predicted)
form 
Solid
color 
Off-White
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
17994
Product name
AZ 5104
Purity
≥98%
Packaging
5mg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
17994
Product name
AZ 5104
Purity
≥98%
Packaging
10mg
Price
$115
Updated
2024/03/01
Cayman Chemical
Product number
17994
Product name
AZ 5104
Purity
≥98%
Packaging
25mg
Price
$270
Updated
2024/03/01
Cayman Chemical
Product number
17994
Product name
AZ 5104
Purity
≥98%
Packaging
50mg
Price
$477
Updated
2024/03/01
TRC
Product number
A795170
Product name
AZ5104
Packaging
1mg
Price
$55
Updated
2021/12/16
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AZ-5104 Chemical Properties,Usage,Production

Uses

AZ7550 is an impurity of the drug Osimertinib (A808075). Osimertinib is a selective EGFR inhibitor (epidermal growth factor receptor), used in the treatments of nonsmall-cell lung cancer (NSCLC).

Biological Activity

az5104, is the demethylated metabolite of azd-9291,is a potent egfr inhibitor. ic50 <1 nm, 6 nm, 1 nm, 25 nm, for egfr (l858r/t790m), egfr (l858r), egfr (l861q), and egfr (wildtype), respectively.egfr (epidermal growth factor receptor) is a receptor tyrosine kinase on the cell surface. the receptor activation leads to dimerization and tyrosine autophosphorylation. it induces downstream cellular responses such as modification in gene expression, cell proliferation and cytoskeletal rearrangement etc.compare to azd9291, az5104 has somewhat more potency in mutant egfr cell lines ex19del (2 nmol/l in pc-9), t790m (2 nmol/l in h1975), and wild-type egfr (33 nmol/l in lovo) cell lines. in a phenotypic assay, az5104 showed a greater potency across cell lines in a phenotypic assay.3 hours after oral dosing in the mouse, the circulating active metabolites in plasma is 33% for az5104. in both c/l858r and c/l+t mice, 5 mg/kg/day dose of az5104, also show efficacy in shrinking tumors.

References

1. cross da, ashton se, ghiorghiu s et al. azd9291, an irreversible egfr tki, overcomes t790m-mediated resistance to egfr inhibitors in lung cancer. cancer discov. 2014 sep;4(9):1046-61.

AZ-5104 Preparation Products And Raw materials

Raw materials

Preparation Products

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AZ-5104 Suppliers

China 109 India 4 United Kingdom 1 United States 16 Global 130
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View Lastest Price from AZ-5104 manufacturers

Career Henan Chemical Co
Product
AZ-5104 1421373-98-9
Price
US $1.00/KG
Min. Order
1KG
Purity
98-100%
Supply Ability
1000kg
Release date
2018-08-20

1421373-98-9, AZ-5104Related Search:

1,2,4-Benzenetriamine, N4-[4-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-2-pyrimidinyl]-N1-[2-(dimethylamino)ethyl]-5-methoxy-N1-methyl- Osimertinib Impurity 7 Osimertinib Impurity N 2-Propenamide, N-[2-[[2-(dimethyloxidoamino)ethyl]methyloxidoamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]- 1,2,4-Benzenetriamine, 5-methoxy-N1,N1-dimethyl-N4-[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]- 1,2,4-Benzenetriamine, N4-[4-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-2-pyrimidinyl]-5-methoxy-N1-methyl-N1-[2-(methylmethyl-d3-amino)ethyl]- Osimertinib Impurity M N-(2-(dimethylamino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide AZ 7550 1,4-Benzenediamine, 5-methoxy-N1,N1-dimethyl-N4-[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]-2-nitro- 3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide

  • N-[2-[[2-(Dimethylamino)ethyl]methylamino]-5-[[4-(1H-indol-3-yl)-2-pyrimidinyl]amino]-4-methoxyphenyl]-2-propenamide
  • AZ5104
  • AZ-5104
  • N-(5-((4-(1H-indol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide
  • AZ7550
  • AZ5104; AZ-5104
  • N-[2-(2-dimethylaminoethylmethylamino)-5-[[4-(1H-indol-3-yl)pyrimidin-2-yl]amino]-4-methoxyphenyl]prop-2-enamide
  • AZD5104
  • AZ-5104;AZ 5104
  • CS-1709
  • N-(4-methoxy-2-(methyl(2-(methylamino)ethyl)amino)-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide
  • Osimertinib Impurity A
  • 2-Propenamide, N-[2-[[2-(dimethylamino)ethyl]methylamino]-5-[[4-(1H-indol-3-yl)-2-pyrimidinyl]amino]-4-methoxyphenyl]-
  • Demethylated AZ9291
  • metabolite of AZD9291
  • 1421373-98-9
  • C27H31N7O2
  • Inhibitors