Methyl 5-bromo-1-methyl-1H-pyrazole-3-carboxylate
- Product Name
- Methyl 5-bromo-1-methyl-1H-pyrazole-3-carboxylate
- CAS No.
- 1222174-92-6
- Chemical Name
- Methyl 5-bromo-1-methyl-1H-pyrazole-3-carboxylate
- Synonyms
- methyl 5-bromo-1-methylpyrazole-3-carboxylate;Methyl 5-bromo-1-methyl-1H-pyrazole-3-carboxylate;1H-Pyrazole-3-carboxylic acid, 5-bromo-1-methyl-, methyl ester
- CBNumber
- CB12742071
- Molecular Formula
- C6H7BrN2O2
- Formula Weight
- 219.04
- MOL File
- 1222174-92-6.mol
Methyl 5-bromo-1-methyl-1H-pyrazole-3-carboxylate Property
- Boiling point:
- 280.4±20.0 °C(Predicted)
- Density
- 1.67±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -1.41±0.10(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- A246677
- Product name
- Methyl5-bromo-1-methyl-1H-pyrazole-3-carboxylate
- Purity
- 97%
- Packaging
- 100mg
- Price
- $37
- Updated
- 2021/12/16
- Product number
- A246677
- Product name
- Methyl5-bromo-1-methyl-1H-pyrazole-3-carboxylate
- Purity
- 97%
- Packaging
- 250mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- CM122215
- Product name
- methyl5-bromo-1-methyl-1H-pyrazole-3-carboxylate
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- CD11323782
- Product name
- Methyl5-bromo-1-methyl-1H-pyrazole-3-carboxylate
- Purity
- 97%
- Packaging
- 1g
- Price
- $145
- Updated
- 2021/12/16
- Product number
- A246677
- Product name
- Methyl5-bromo-1-methyl-1H-pyrazole-3-carboxylate
- Purity
- 97%
- Packaging
- 1g
- Price
- $168
- Updated
- 2021/12/16
Methyl 5-bromo-1-methyl-1H-pyrazole-3-carboxylate Chemical Properties,Usage,Production
Synthesis
51985-95-6
1222174-92-6
General procedure for the synthesis of 5-bromo-1-methyl-1H-pyrazole-3-carboxylic acid methyl ester from 1-methyl-5-hydroxypyrazole-3-carboxylic acid: firstly, 1-methyl-5-hydroxypyrazole-3-carboxylic acid methyl ester (64 mmol) was dissolved in acetonitrile (200 mL) and then phosphorus tribromide (POBr3, 322 mmol) was added. The reaction mixture was transferred to a sealed flask and heated at 80 °C for 15 hours. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently slowly poured into a saturated aqueous sodium bicarbonate solution pre-cooled to 0 °C. The reaction solution was extracted three times with ethyl acetate and the organic phases were combined. The organic phase was decolorized by activated carbon, dried with anhydrous sodium sulfate, filtered, and the filtrate was concentrated under reduced pressure to afford a brown oily product, which solidified to the target compound 5-bromo-1-methyl-1H-pyrazole-3-carboxylic acid methyl ester in a yield of 11.5 g and 72% yield after standing. The product was analyzed by LC/MS with ESI m/z (M+H)+ = 220.2.
References
[1] Patent: WO2010/45188, 2010, A1. Location in patent: Page/Page column 49; 50
[2] Journal of Medicinal Chemistry, 2011, vol. 54, # 23, p. 8174 - 8187
[3] Patent: WO2012/122340, 2012, A1. Location in patent: Page/Page column 69
[4] Patent: US2014/194452, 2014, A1. Location in patent: Paragraph 0344-0346
[5] Patent: WO2014/108336, 2014, A1. Location in patent: Page/Page column 47
Methyl 5-bromo-1-methyl-1H-pyrazole-3-carboxylate Preparation Products And Raw materials
Raw materials
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View Lastest Price from Methyl 5-bromo-1-methyl-1H-pyrazole-3-carboxylate manufacturers
- Product
- methyl 5-bromo-1-methylpyrazole-3-carboxylate 1222174-92-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.0001kg
- Purity
- 98%min
- Supply Ability
- 100kgs/month
- Release date
- 2022-05-09