LL Z1640-2

Product Name: LL Z1640-2
CAS No.: 253863-19-3
Chemical Name: LL Z1640-2
Synonyms: nol;C 292;L 783279;FR148083;f 152 A1;5Z-7-Oxoze&ÆTAK1 inhibitor 5ZO);5Z-7-Oxozeaenol >=98% (HPLC);1H-2-Benzoxacyclotetradecin-1,7(8H)-dione, 3,4,9,10-tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-, (3S,5Z,8S,9S,11E)-;(2E,5S,6S,8Z,11S)-5,6,15-trihydroxy-17-methoxy-11-methyl-12-oxabicyclo[12.4.0]octadeca-1(14),2,8,15,17-pentaene-7,13-dione
CBNumber: CB12744545
Molecular Formula: C19H22O7
Formula Weight: 362.37
MOL File: 253863-19-3.mol

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LL Z1640-2 Property

Melting point:: 171-173 °C(Solv: dichloromethane (75-09-2); hexane (110-54-3))
Boiling point:: 666.8±55.0 °C(Predicted)
Density: 1.270±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: >10mg/mL
form: powder
pka: 7.32±0.70(Predicted)
color: white to off-white

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
WGK Germany: 3
HS Code: 3507909090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: O9890
Product name: 5Z-7-Oxozeaenol
Purity: ≥98% (HPLC)
Packaging: 1mg
Price: $221
Updated: 2024/03/01

Cayman Chemical

Product number: 17459
Product name: (5Z)-7-Oxo Zeaenol
Purity: ≥99%
Packaging: 1mg
Price: $86
Updated: 2024/03/01

Cayman Chemical

Product number: 17459
Product name: (5Z)-7-Oxo Zeaenol
Purity: ≥99%
Packaging: 5mg
Price: $299
Updated: 2024/03/01

TRC

Product number: O870678
Product name: (5Z)-7-Oxozeaenol
Packaging: 5mg
Price: $655
Updated: 2021/12/16

Apolloscientific

Product number: BIL0128
Product name: LL-Z-1640-2
Packaging: 10mg
Price: $595
Updated: 2021/12/16

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LL Z1640-2 Chemical Properties,Usage,Production

Uses

LL Z1640-2 (5Z-7-oxozeaenol) is a cis-enone resorcylic acid lactone first reported in 1978 and later rediscovered as an irreversible and highly selective TAK 1 inhibitor. TAK1 is a MAPKKK involved in the p38 signalling cascade for pro-inflammation signals such as cytokines. LL Z1640-2 effectively prevents inflammation in animal models.

Uses

(5Z)-7-Oxozeaenol is a highly potent inhibitor of TAK1, which is a member of the mitogen-acitvated kinase kinase kinase (MAPKKK) family. 5Z-?7-?Oxozeaenol blocked interleukin-?1-?induced activation of TAK1, JNK?/p38 MAPK, IκB kinases, and NF-?κB, resulting in inhibition of cyclooxgenase-?2 production.

Definition

ChEBI: 5Z-7-oxozeaenol is a macrolide that is the 7-oxo derivative of zeaenol (the 5Z stereoisomer). Isolated from Fungi, it exhibits cytotoxic, antibacterial and inhibitory activity against NF-kappaB. It has a role as a metabolite, an antibacterial agent, an antineoplastic agent and a NF-kappaB inhibitor. It is an aromatic ether, a macrolide, a member of phenols, a secondary alcohol and a secondary alpha-hydroxy ketone.

Biochem/physiol Actions

The anti-inflammatory effects of 5Z-7-oxozeaenol may affect cardiac hypertrophy.

storage

Desiccate at -20°C

LL Z1640-2 Preparation Products And Raw materials

Raw materials

Preparation Products

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LL Z1640-2 Suppliers

China 27 United Kingdom 2 United States 6 Global 35

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253863-19-3, LL Z1640-2Related Search:

f 152 A1

(2E,5S,6S,8Z,11S)-5,6,15-trihydroxy-17-methoxy-11-methyl-12-oxabicyclo[12.4.0]octadeca-1(14),2,8,15,17-pentaene-7,13-dione

C 292

FR148083

L 783279

TAK1 inhibitor 5ZO)

1H-2-Benzoxacyclotetradecin-1,7(8H)-dione, 3,4,9,10-tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-, (3S,5Z,8S,9S,11E)-

5Z-7-Oxozeaenol >=98% (HPLC)

nol

5Z-7-Oxoze&&AElig

253863-19-3