LL Z1640-2
- Product Name
- LL Z1640-2
- CAS No.
- 253863-19-3
- Chemical Name
- LL Z1640-2
- Synonyms
- nol;C 292;L 783279;FR148083;f 152 A1;5Z-7-Oxoze&ÆTAK1 inhibitor 5ZO);5Z-7-Oxozeaenol >=98% (HPLC);1H-2-Benzoxacyclotetradecin-1,7(8H)-dione, 3,4,9,10-tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-, (3S,5Z,8S,9S,11E)-;(2E,5S,6S,8Z,11S)-5,6,15-trihydroxy-17-methoxy-11-methyl-12-oxabicyclo[12.4.0]octadeca-1(14),2,8,15,17-pentaene-7,13-dione
- CBNumber
- CB12744545
- Molecular Formula
- C19H22O7
- Formula Weight
- 362.37
- MOL File
- 253863-19-3.mol
LL Z1640-2 Property
- Melting point:
- 171-173 °C(Solv: dichloromethane (75-09-2); hexane (110-54-3))
- Boiling point:
- 666.8±55.0 °C(Predicted)
- Density
- 1.270±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: >10mg/mL
- form
- powder
- pka
- 7.32±0.70(Predicted)
- color
- white to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- O9890
- Product name
- 5Z-7-Oxozeaenol
- Purity
- ≥98% (HPLC)
- Packaging
- 1mg
- Price
- $221
- Updated
- 2024/03/01
- Product number
- 17459
- Product name
- (5Z)-7-Oxo Zeaenol
- Purity
- ≥99%
- Packaging
- 1mg
- Price
- $86
- Updated
- 2024/03/01
- Product number
- 17459
- Product name
- (5Z)-7-Oxo Zeaenol
- Purity
- ≥99%
- Packaging
- 5mg
- Price
- $299
- Updated
- 2024/03/01
- Product number
- O870678
- Product name
- (5Z)-7-Oxozeaenol
- Packaging
- 5mg
- Price
- $655
- Updated
- 2021/12/16
- Product number
- BIL0128
- Product name
- LL-Z-1640-2
- Packaging
- 10mg
- Price
- $595
- Updated
- 2021/12/16
LL Z1640-2 Chemical Properties,Usage,Production
Uses
LL Z1640-2 (5Z-7-oxozeaenol) is a cis-enone resorcylic acid lactone first reported in 1978 and later rediscovered as an irreversible and highly selective TAK 1 inhibitor. TAK1 is a MAPKKK involved in the p38 signalling cascade for pro-inflammation signals such as cytokines. LL Z1640-2 effectively prevents inflammation in animal models.
Uses
(5Z)-7-Oxozeaenol is a highly potent inhibitor of TAK1, which is a member of the mitogen-acitvated kinase kinase kinase (MAPKKK) family. 5Z-?7-?Oxozeaenol blocked interleukin-?1-?induced activation of TAK1, JNK?/p38 MAPK, IκB kinases, and NF-?κB, resulting in inhibition of cyclooxgenase-?2 production.
Definition
ChEBI: 5Z-7-oxozeaenol is a macrolide that is the 7-oxo derivative of zeaenol (the 5Z stereoisomer). Isolated from Fungi, it exhibits cytotoxic, antibacterial and inhibitory activity against NF-kappaB. It has a role as a metabolite, an antibacterial agent, an antineoplastic agent and a NF-kappaB inhibitor. It is an aromatic ether, a macrolide, a member of phenols, a secondary alcohol and a secondary alpha-hydroxy ketone.
Biochem/physiol Actions
The anti-inflammatory effects of 5Z-7-oxozeaenol may affect cardiac hypertrophy.
storage
Desiccate at -20°C
LL Z1640-2 Preparation Products And Raw materials
Raw materials
Preparation Products
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