tert-Butyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate

Uses

Product Name: tert-Butyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate
CAS No.: 478837-18-2
Chemical Name: tert-Butyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate
Synonyms: 1-(METHYLSULFONYL)PIPERIDIN-4-AMINE HYDR;N-Boc-3-hydroxy-8-azabicyclo[3.2.1]octane;2-Methyl-2-propanyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate;3-hydroxy-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid, tert-butyl ester;8-Azabicyclo[3.2.1]octane-8-carboxylic acid, 3-hydroxy-,1,1-dimethylethyl ester
CBNumber: CB12745436
Molecular Formula: C12H21NO3
Formula Weight: 227.3
MOL File: 478837-18-2.mol

More

Less

tert-Butyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate Property

Boiling point:: 327.9±35.0 °C(Predicted)
Density: 1.146±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 14.79±0.20(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C12H21NO3/c1-12(2,3)16-11(15)13-8-4-5-9(13)7-10(14)6-8/h8-10,14H,4-7H2,1-3H3
InChIKey: SEGZJJSZYOEABC-UHFFFAOYSA-N
SMILES: C12N(C(OC(C)(C)C)=O)C(CC1)CC(O)C2

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

TRC

Product number: B810093
Product name: tert-Butyl3-Hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate
Packaging: 500mg
Price: $130
Updated: 2021/12/16

ChemScene

Product number: CS-0041898
Product name: tert-Butyl3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate
Purity: ≥97.0%
Packaging: 25g
Price: $606
Updated: 2021/12/16

ChemScene

Product number: CS-0041898
Product name: tert-Butyl3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate
Purity: ≥97.0%
Packaging: 10g
Price: $307
Updated: 2021/12/16

Matrix Scientific

Product number: 174682
Product name: tert-Butyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate
Packaging: 1g
Price: $316
Updated: 2021/12/16

ChemScene

Product number: CS-0041898
Product name: tert-Butyl3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate
Purity: ≥97.0%
Packaging: 1g
Price: $55
Updated: 2021/12/16

More

Less

tert-Butyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate Chemical Properties,Usage,Production

Uses

N-BOC-3-hydroxy-8-azabicyclo[3.2.1]octane is an alkane organic compound that can be used as a pharmaceutical intermediate.

Synthesis

185099-67-6

478837-18-2

The general procedure for the synthesis of tert-butyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate using 3-oxo-8-azabicyclo[3.2.1]octane-8-carboxylic acid as a starting material was as follows: sodium borohydride (178 mg, 4.7 mmol) was slowly added to a solution of tert-butyl 3-oxo-8-azabicyclo[3.2.1]octane-8-carboxylate (0.50 g, 2.2 mmol) at room temperature. butyl ester (0.50 g, 2.2 mmol) in a solution of ethanol (10 mL). The reaction mixture was stirred continuously for 1 hour at room temperature. Upon completion of the reaction, the reaction was quenched with saturated ammonium chloride solution (30 mL) followed by extraction with ethyl acetate (3 x 20 mL). The organic phases were combined, washed sequentially with water and brine, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to afford the title compound tert-butyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate (463 mg, 92% yield) as a mixture of endo and exo stereoisomers. The product was analyzed by GC-MS (EI) and the molecular ion peak (M+) of molecular formula C12H21NO3 was 227.

References

[1] Patent: WO2010/138490, 2010, A1. Location in patent: Page/Page column 33
[2] Patent: WO2012/71509, 2012, A2. Location in patent: Page/Page column 166
[3] Patent: US2007/249672, 2007, A1. Location in patent: Page/Page column 21
[4] Patent: WO2010/75269, 2010, A1. Location in patent: Page/Page column 44
[5] Patent: WO2010/138487, 2010, A1. Location in patent: Page/Page column 131

tert-Butyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

tert-Butyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate Suppliers

China 31 India 1 United States 3 Global 35

Wuhan YlypharmTech Co.,L

Tel: 027-87212669 15927337358
Fax: 027-87212669
Email: Sales@ylypharmtech.com
Country: China
ProdList: 396
Advantage: 58

Shanghai Sunway Pharmaceutical Technology Co., Ltd

Tel: 13761987713
Fax: 021 51613951
Email: hxzheng@sunwaypharm.cn
Country: China
ProdList: 8667
Advantage: 57

Chengdu HappySyn Pharmaceutical Technology Co., Ltd.

Tel: 028-85114309 18982182443
Email: yangli@happysyn.com
Country: China
ProdList: 2220
Advantage: 55

Cool Pharm, Ltd

Tel: 021-60455363 18019463053
Fax: 50966098
Email: sales@coolpharm.com
Country: China
ProdList: 12346
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Amatek Scientific Co. Ltd.

Tel: 0512-56316828
Fax: 0512-56316826
Email: info@amateksci.com
Country: China
ProdList: 28772
Advantage: 58

Aikon International Limited

Tel: 025-58851090 15955137747
Fax: (6)02557626880
Email: sales01@aikonchem.com
Country: China
ProdList: 15949
Advantage: 58

Nanjing SynTitan Pharmaceutical Co., Ltd.

Tel: 025-57027686 17372956142
Fax: 025-57027686
Email: li_lan@syntitan.com
Country: China
ProdList: 9999
Advantage: 58

Aishilun biotechnology (Shanghai) co., LTD

Tel: 021-50676523 18019098996
Email: info@acelybio.com
Country: China
ProdList: 3960
Advantage: 58

Labnetwork lnc.

Tel: +86-27-50766799 +8618062016861
Email: contact@labnetwork.com
Country: China
ProdList: 19987
Advantage: 58

478837-18-2, tert-Butyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylateRelated Search:

2-Methyl-2-propanyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate

N-Boc-3-hydroxy-8-azabicyclo[3.2.1]octane

8-Azabicyclo[3.2.1]octane-8-carboxylic acid, 3-hydroxy-,1,1-dimethylethyl ester

3-hydroxy-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid, tert-butyl ester

1-(METHYLSULFONYL)PIPERIDIN-4-AMINE HYDR

478837-18-2