ML335

ChemicalBook > CAS DataBase List > ML335

Product Name: ML335
CAS No.: 1069498-96-9
Chemical Name: ML335
Synonyms: ML335;CYM51010;CID23723457;ML 335,ML335;CYM51010(ML335);Ethyl 1-(4-acetamidobenzyl)-4- phenethylpiperidine-4-carboxylate;1-[[4-(Acetylamino)phenyl]methyl]-4-(2-phenylethyl)-4-Piperidinecarboxylic acid ethyl ester;4-Piperidinecarboxylic acid, 1-[[4-(acetylamino)phenyl]methyl]-4-(2-phenylethyl)-, ethyl ester
CBNumber: CB12750520
Molecular Formula: C25H32N2O3
Formula Weight: 408.53
MOL File: 1069498-96-9.mol

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ML335 Property

storage temp.: 2-8°C
solubility: DMSO: soluble10mg/mL, clear
form: powder
color: white to beige

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0980
Product name: CYM51010
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $119
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0980
Product name: CYM51010
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $594
Updated: 2024/03/01

Cayman Chemical

Product number: 15196
Product name: ML-335
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 15196
Product name: ML-335
Purity: ≥98%
Packaging: 5mg
Price: $118
Updated: 2024/03/01

Cayman Chemical

Product number: 15196
Product name: ML-335
Purity: ≥98%
Packaging: 10mg
Price: $193
Updated: 2024/03/01

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ML335 Chemical Properties,Usage,Production

Description

The μ-opioid receptor (OPRM1) is the primary site of action for morphine and other opioids associated with the treatment of pain. The occupancy of δ-opioid receptors (OPRD1) by antagonists has been shown to enhance OPRM1 binding and signaling activity. Because heteromerization of OPRM1 and OPRD1 is thought to be a potential mechanism by which this occurs, compounds are being sought that selectively activate OPRM1-OPRD1 heterodimerization while alleviating the unwanted effects associated with prolonged opiate use. ML-335 is the first identified agonist for OPRM1-OPRD1 heterodimerization (EC₅₀ = 403 nM) that demonstrates selectivity over the individual OPRM1 and OPRD1 receptors and the serotonin HT5A receptor (EC₅₀s = 14.9, 1.1, and >40 μM, respectively).

Uses

ML335, is a selective activator of both TREK-1 and TREK-2.

Uses

ML-335 is an agonist for μ-opioid receptor (OPRM1)- δ-opioid receptors (OPRD1) heterodimerization.

ML335 Preparation Products And Raw materials

Raw materials

Preparation Products

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1069498-96-9, ML335Related Search:

1-[[4-(Acetylamino)phenyl]methyl]-4-(2-phenylethyl)-4-Piperidinecarboxylic acid ethyl ester

CID23723457

CYM51010

ML335

4-Piperidinecarboxylic acid, 1-[[4-(acetylamino)phenyl]methyl]-4-(2-phenylethyl)-, ethyl ester

CYM51010(ML335)

Ethyl 1-(4-acetamidobenzyl)-4- phenethylpiperidine-4-carboxylate

ML 335,ML335

1069498-96-9