4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine

Product Name: 4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine
CAS No.: 854847-61-3
Chemical Name: 4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine
Synonyms: HLY78;5-j]phenanthridine;4-Ethyl-5-methyl-5;HLY78 >=98% (HPLC);4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine;4-Ethyl-5,6-Dihydro-5-methyl-[1,3]dioxolo[4,5-j]phenanthridine;[1,3]Dioxolo[4,5-j]phenanthridine, 4-ethyl-5,6-dihydro-5-methyl-;Beta catenin,Neuronal apoptosis,HLY78,gastric cancer,SAH,subarachnoid hemorrhage,tumor cells,β-catenin,LRP6,inhibit,Inhibitor,anti-apoptotic,Blood-brain barrier,embryonic cells,Apoptosis,HLY-78,Wnt,HLY 78
CBNumber: CB12750601
Molecular Formula: C17H17NO2
Formula Weight: 267.32
MOL File: 854847-61-3.mol

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4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine Property

Boiling point:: 444.0±34.0 °C(Predicted)
Density: 1.208±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble5mg/mL, clear (warmed)
form: powder
pka: 4?+-.0.20(Predicted)
color: white to beige

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Safety

Hazard Codes: N
Risk Statements: 50/53
Safety Statements: 60-61
RIDADR: UN 3077 9 / PGIII
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0833
Product name: HLY78
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $94.3
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0833
Product name: HLY78
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $479
Updated: 2024/03/01

Cayman Chemical

Product number: 19087
Product name: HLY78
Purity: ≥98%
Packaging: 1mg
Price: $45
Updated: 2024/03/01

Cayman Chemical

Product number: 19087
Product name: HLY78
Purity: ≥98%
Packaging: 5mg
Price: $100
Updated: 2024/03/01

Cayman Chemical

Product number: 19087
Product name: HLY78
Purity: ≥98%
Packaging: 10mg
Price: $177
Updated: 2024/03/01

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4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine Chemical Properties,Usage,Production

Biological Activity

hly78 is a positive modulator of the wnt/β-catenin pathway.the evolutionarily conserved wnt/β-catenin signaling pathway has important roles in embryonic development and human diseases. during embryogenesis, the wnt signaling pathway regulates cell fate specification, differentiation, proliferation and survival. inappropriate regulation of the wnt signaling pathway is usually related to the progression of various human diseases including cancer, familial exudative vitreoretinopathy, alzheimer’s disease, and bone formation disorders.

in vitro

by screening a synthetic chemical library of lycorine derivatives, hly78 was identified as an activator of the wnt/β-catenin signaling pathway, which acted in a wnt ligand-dependent manner. hly78 was found to be alble to target the dix domain of axin and potentiate the axin-lrp6 association, therefore leading to the promotion of lrp6 phosphorylation and wnt signaling transduction. in addition, this study also identified the critical residues on axin for hly78 binding and suggested that hly78 might weaken the autoinhibition of axin1 [1].

in vivo

in-vivo study showed that hly78 could synergistically act with wnt in the embryonic development of zebrafish and increase the expression of the conserved hematopoietic stem cell (hsc) markers, cmyb and runx1, in zebrafish embryos [1].

References

[1] wang, s. ,yin, j.,chen, d., et al. small-molecule modulation of wnt signaling via modulating the axin-lrp5/6 interaction. nature chemical biology 9, 579-585 (2013).

4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine Suppliers

China 35 United Kingdom 1 United States 6 Global 42

ShangHai Caerulum Pharma Discovery Co., Ltd.

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Novachemistry

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TargetMol Chemicals Inc.

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854847-61-3, 4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridineRelated Search:

4-Ethyl-5,6-Dihydro-5-methyl-[1,3]dioxolo[4,5-j]phenanthridine

4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine

HLY78

[1,3]Dioxolo[4,5-j]phenanthridine, 4-ethyl-5,6-dihydro-5-methyl-

HLY78 >=98% (HPLC)

4-Ethyl-5-methyl-5

5-j]phenanthridine

Beta catenin,Neuronal apoptosis,HLY78,gastric cancer,SAH,subarachnoid hemorrhage,tumor cells,β-catenin,LRP6,inhibit,Inhibitor,anti-apoptotic,Blood-brain barrier,embryonic cells,Apoptosis,HLY-78,Wnt,HLY 78

854847-61-3