4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine
- Product Name
- 4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine
- CAS No.
- 854847-61-3
- Chemical Name
- 4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine
- Synonyms
- HLY78;5-j]phenanthridine;4-Ethyl-5-methyl-5;HLY78 >=98% (HPLC);4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine;4-Ethyl-5,6-Dihydro-5-methyl-[1,3]dioxolo[4,5-j]phenanthridine;[1,3]Dioxolo[4,5-j]phenanthridine, 4-ethyl-5,6-dihydro-5-methyl-;Beta catenin,Neuronal apoptosis,HLY78,gastric cancer,SAH,subarachnoid hemorrhage,tumor cells,β-catenin,LRP6,inhibit,Inhibitor,anti-apoptotic,Blood-brain barrier,embryonic cells,Apoptosis,HLY-78,Wnt,HLY 78
- CBNumber
- CB12750601
- Molecular Formula
- C17H17NO2
- Formula Weight
- 267.32
- MOL File
- 854847-61-3.mol
4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine Property
- Boiling point:
- 444.0±34.0 °C(Predicted)
- Density
- 1.208±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble5mg/mL, clear (warmed)
- form
- powder
- pka
- 4?+-.0.20(Predicted)
- color
- white to beige
N-Bromosuccinimide Price
- Product number
- SML0833
- Product name
- HLY78
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $94.3
- Updated
- 2024/03/01
- Product number
- SML0833
- Product name
- HLY78
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $479
- Updated
- 2024/03/01
- Product number
- 19087
- Product name
- HLY78
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $45
- Updated
- 2024/03/01
- Product number
- 19087
- Product name
- HLY78
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $100
- Updated
- 2024/03/01
- Product number
- 19087
- Product name
- HLY78
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $177
- Updated
- 2024/03/01
4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine Chemical Properties,Usage,Production
Biological Activity
hly78 is a positive modulator of the wnt/β-catenin pathway.the evolutionarily conserved wnt/β-catenin signaling pathway has important roles in embryonic development and human diseases. during embryogenesis, the wnt signaling pathway regulates cell fate specification, differentiation, proliferation and survival. inappropriate regulation of the wnt signaling pathway is usually related to the progression of various human diseases including cancer, familial exudative vitreoretinopathy, alzheimer’s disease, and bone formation disorders.
in vitro
by screening a synthetic chemical library of lycorine derivatives, hly78 was identified as an activator of the wnt/β-catenin signaling pathway, which acted in a wnt ligand-dependent manner. hly78 was found to be alble to target the dix domain of axin and potentiate the axin-lrp6 association, therefore leading to the promotion of lrp6 phosphorylation and wnt signaling transduction. in addition, this study also identified the critical residues on axin for hly78 binding and suggested that hly78 might weaken the autoinhibition of axin1 [1].
in vivo
in-vivo study showed that hly78 could synergistically act with wnt in the embryonic development of zebrafish and increase the expression of the conserved hematopoietic stem cell (hsc) markers, cmyb and runx1, in zebrafish embryos [1].
References
[1] wang, s. ,yin, j.,chen, d., et al. small-molecule modulation of wnt signaling via modulating the axin-lrp5/6 interaction. nature chemical biology 9, 579-585 (2013).
4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine Preparation Products And Raw materials
Raw materials
Preparation Products
4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine Suppliers
- Tel
- 18149758185
- sales-cpd@caerulumpharma.com
- Country
- China
- ProdList
- 3423
- Advantage
- 58
- Tel
- 021-52996696,15000506266 15000506266
- Fax
- +86-21-52996696
- Country
- China
- ProdList
- 4153
- Advantage
- 55
- Tel
- +86-400-851-9921
- Fax
- +86-10-82826195
- sales@pharmacodia.com
- Country
- China
- ProdList
- 2317
- Advantage
- 55
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9709
- Advantage
- 58
- Tel
- 17754423994 17754423994
- Fax
- QQ:2853530913
- 2853530910@QQ.com
- Country
- China
- ProdList
- 8011
- Advantage
- 62
- Tel
- 21-31433387 15618786686
- Fax
- QQ:1369748377
- sales@rechemscience.com
- Country
- China
- ProdList
- 2990
- Advantage
- 58
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131981
- Advantage
- 58
- Tel
- 86-(0)29-85992781 17792393971
- info@lynnchem.com
- Country
- China
- ProdList
- 4587
- Advantage
- 58
- Tel
- 021-58447131 13564518121
- sales@dcchemicals.com
- Country
- China
- ProdList
- 9414
- Advantage
- 58
- Tel
- 0519-85788828 13775037613
- sales@chemrenpharm.com
- Country
- China
- ProdList
- 3553
- Advantage
- 58
- Tel
- 028-81700200 18108052721
- 2850505130@qq.com
- Country
- China
- ProdList
- 5182
- Advantage
- 58
- Tel
- 63313187 15358055255
- Fax
- QQ:63313187
- 63313187@qq.com
- Country
- China
- ProdList
- 1977
- Advantage
- 58
- Tel
- 021-69568360 18916172912
- order@med-bio.cn
- Country
- China
- ProdList
- 8141
- Advantage
- 58
- Tel
- 021-58432009 400-005-6266
- Fax
- 021-58436166
- marketing@energy-chemical.com
- Country
- China
- ProdList
- 44941
- Advantage
- 58
- Tel
- 18051384581
- sales@chemhifuture.com
- Country
- China
- ProdList
- 3061
- Advantage
- 58
- Tel
- 010-60605840
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 29778
- Advantage
- 58
- Tel
- 027-59101668 19945030958
- Fax
- 027-59101668
- 2881924765@qq.com
- Country
- China
- ProdList
- 7977
- Advantage
- 58
- Tel
- 13549236410
- sales@invivochem.cn
- Country
- China
- ProdList
- 6712
- Advantage
- 58
- Tel
- +86-027-59232304 15387063101
- 2881924050@qq.com
- Country
- China
- ProdList
- 9892
- Advantage
- 58
- Tel
- 4008200310
- marketing@tsbiochem.com
- Country
- China
- ProdList
- 24023
- Advantage
- 58
- Tel
- 021-50706066 15221275939
- shenlinxing@macklin.cn
- Country
- China
- ProdList
- 29803
- Advantage
- 58
- Tel
- 13854185395; 13854185395
- sanbaobiotech@126.com
- Country
- China
- ProdList
- 9324
- Advantage
- 58
- Tel
- 021-54306202 18917919676
- info@hanhongsci.com
- Country
- China
- ProdList
- 29989
- Advantage
- 58
- Tel
- 18502726233
- 3641133981@qq.com
- Country
- China
- ProdList
- 9295
- Advantage
- 58
- Tel
- 025-85560043 15850508050
- Fax
- 025-85563444
- cindy.huang@synzest.com
- Country
- China
- ProdList
- 12007
- Advantage
- 58
- Tel
- +undefined18051384581
- sales@chemhifuture.com
- Country
- China
- ProdList
- 3136
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@zzsrm.com
- Country
- CHINA
- ProdList
- 6846
- Advantage
- 58
- Tel
- --
- Fax
- --
- 1861586486@qq.com
- Country
- CHINA
- ProdList
- 6652
- Advantage
- 58
- Tel
- --
- Fax
- --
- lyn@biopike.com.cn
- Country
- CHINA
- ProdList
- 6629
- Advantage
- 58
- Tel
- --
- Fax
- --
- chenxue_gz@163.com
- Country
- CHINA
- ProdList
- 6618
- Advantage
- 58
- Tel
- --
- Fax
- --
- chenjw@absin.cn
- Country
- CHINA
- ProdList
- 6661
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@wheybio.com
- Country
- CHINA
- ProdList
- 4398
- Advantage
- 58
- Tel
- --
- Fax
- --
- shxiyuanbio@163.com
- Country
- CHINA
- ProdList
- 6921
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@f-biology.com
- Country
- CHINA
- ProdList
- 6039
- Advantage
- 58