ChemicalBook > CAS DataBase List > 4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine

4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine

Product Name
4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine
CAS No.
854847-61-3
Chemical Name
4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine
Synonyms
HLY78;5-j]phenanthridine;4-Ethyl-5-methyl-5;HLY78 >=98% (HPLC);4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine;4-Ethyl-5,6-Dihydro-5-methyl-[1,3]dioxolo[4,5-j]phenanthridine;[1,3]Dioxolo[4,5-j]phenanthridine, 4-ethyl-5,6-dihydro-5-methyl-;Beta catenin,Neuronal apoptosis,HLY78,gastric cancer,SAH,subarachnoid hemorrhage,tumor cells,β-catenin,LRP6,inhibit,Inhibitor,anti-apoptotic,Blood-brain barrier,embryonic cells,Apoptosis,HLY-78,Wnt,HLY 78
CBNumber
CB12750601
Molecular Formula
C17H17NO2
Formula Weight
267.32
MOL File
854847-61-3.mol
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4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine Property

Boiling point:
444.0±34.0 °C(Predicted)
Density 
1.208±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: soluble5mg/mL, clear (warmed)
form 
powder
pka
4?+-.0.20(Predicted)
color 
white to beige
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Safety

Hazard Codes 
N
Risk Statements 
50/53
Safety Statements 
60-61
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0833
Product name
HLY78
Purity
≥98% (HPLC)
Packaging
5mg
Price
$94.3
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0833
Product name
HLY78
Purity
≥98% (HPLC)
Packaging
25mg
Price
$479
Updated
2024/03/01
Cayman Chemical
Product number
19087
Product name
HLY78
Purity
≥98%
Packaging
1mg
Price
$45
Updated
2024/03/01
Cayman Chemical
Product number
19087
Product name
HLY78
Purity
≥98%
Packaging
5mg
Price
$100
Updated
2024/03/01
Cayman Chemical
Product number
19087
Product name
HLY78
Purity
≥98%
Packaging
10mg
Price
$177
Updated
2024/03/01
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4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine Chemical Properties,Usage,Production

Biological Activity

hly78 is a positive modulator of the wnt/β-catenin pathway.the evolutionarily conserved wnt/β-catenin signaling pathway has important roles in embryonic development and human diseases. during embryogenesis, the wnt signaling pathway regulates cell fate specification, differentiation, proliferation and survival. inappropriate regulation of the wnt signaling pathway is usually related to the progression of various human diseases including cancer, familial exudative vitreoretinopathy, alzheimer’s disease, and bone formation disorders.

in vitro

by screening a synthetic chemical library of lycorine derivatives, hly78 was identified as an activator of the wnt/β-catenin signaling pathway, which acted in a wnt ligand-dependent manner. hly78 was found to be alble to target the dix domain of axin and potentiate the axin-lrp6 association, therefore leading to the promotion of lrp6 phosphorylation and wnt signaling transduction. in addition, this study also identified the critical residues on axin for hly78 binding and suggested that hly78 might weaken the autoinhibition of axin1 [1].

in vivo

in-vivo study showed that hly78 could synergistically act with wnt in the embryonic development of zebrafish and increase the expression of the conserved hematopoietic stem cell (hsc) markers, cmyb and runx1, in zebrafish embryos [1].

References

[1] wang, s. ,yin, j.,chen, d., et al. small-molecule modulation of wnt signaling via modulating the axin-lrp5/6 interaction. nature chemical biology 9, 579-585 (2013).

4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine Suppliers

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854847-61-3, 4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridineRelated Search:


  • 4-Ethyl-5,6-Dihydro-5-methyl-[1,3]dioxolo[4,5-j]phenanthridine
  • 4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine
  • HLY78
  • [1,3]Dioxolo[4,5-j]phenanthridine, 4-ethyl-5,6-dihydro-5-methyl-
  • HLY78 >=98% (HPLC)
  • 4-Ethyl-5-methyl-5
  • 5-j]phenanthridine
  • Beta catenin,Neuronal apoptosis,HLY78,gastric cancer,SAH,subarachnoid hemorrhage,tumor cells,β-catenin,LRP6,inhibit,Inhibitor,anti-apoptotic,Blood-brain barrier,embryonic cells,Apoptosis,HLY-78,Wnt,HLY 78
  • 854847-61-3