1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea
- Product Name
- 1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea
- CAS No.
- 1384424-80-9
- Chemical Name
- 1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea
- Synonyms
- A-1070722;N-(7-Methoxy-4-quinolinyl)-N’-[6-(trifluoromethyl)-2-pyridinyl]urea;1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea;N-(7-Methoxy-4-quinolinyl)-N'-[6-(trifluoromethyl)-2-pyridinyl]urea;Urea, N-(7-methoxy-4-quinolinyl)-N'-[6-(trifluoromethyl)-2-pyridinyl]-;A 1070722,Glycogen synthase kinase-3,inhibit,A1070722,Inhibitor,GSK-3,Glycogen synthase kinase 3,A-1070722
- CBNumber
- CB12751082
- Molecular Formula
- C17H13F3N4O2
- Formula Weight
- 362.31
- MOL File
- 1384424-80-9.mol
1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea Property
- Boiling point:
- 412.5±45.0 °C(Predicted)
- Density
- 1.461±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble15mg/mL, clear
- pka
- 11.57±0.43(Predicted)
- form
- powder
- color
- white to beige
Safety
- Hazard Codes
- T
- Risk Statements
- 25-36/37/38
- Safety Statements
- 36/37/39-45
- RIDADR
- UN 2811 6.1 / PGIII
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML0863
- Product name
- A-1070722
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $123
- Updated
- 2024/03/01
- Product number
- SML0863
- Product name
- A-1070722
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $425
- Updated
- 2022/05/15
- Product number
- 29783
- Product name
- A-1070722
- Packaging
- 5mg
- Price
- $100
- Updated
- 2024/03/01
- Product number
- 29783
- Product name
- A-1070722
- Packaging
- 25mg
- Price
- $343
- Updated
- 2024/03/01
- Product number
- 29783
- Product name
- A-1070722
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea Chemical Properties,Usage,Production
Description
A-1070722 is an inhibitor of glycogen synthase kinase 3β (GSK3β; IC50 = <100 nM).
Uses
N-(7-Methoxy-4-quinolinyl)-N''-[6-(trifluoromethyl)-2-pyridinyl]urea is a neuroprotective agent and a glycogen synthase kinase-3 (GSK-3) inhibitor. GSK-3 is a conserved signaling enzyme that regulates a wide range of biological events (apoptosis, synaptic plasticity, axon formation, and neurogenesis). The enzyme has a conserved catalytic domain for binding ATP and a C-terminal domain with a conserved activation loop for the kinase activity. GSK-3 is a therapeutic target for treating neurodegenerative and psychiatric disorders.
storage
Store at RT
1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea Preparation Products And Raw materials
Raw materials
Preparation Products
1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea Suppliers
- Tel
- 028-81700200 18116577057
- Fax
- 028-81705658
- 3003855609@qq.com
- Country
- China
- ProdList
- 7892
- Advantage
- 56
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9708
- Advantage
- 58
- Tel
- 21-31433387 15618786686
- Fax
- QQ:1369748377
- sales@rechemscience.com
- Country
- China
- ProdList
- 2986
- Advantage
- 58
- Tel
- QQ:65489617 15618227136
- Fax
- 21-5161 9052
- info@SuperLan-chem.com
- Country
- China
- ProdList
- 9833
- Advantage
- 58
- Tel
- 021-2022843681 15618226720
- Fax
- +86-21-51601218
- chaolaichem@foxmail.com
- Country
- China
- ProdList
- 9242
- Advantage
- 58
- Tel
- 18818260767
- Fax
- QQ 3610331285
- sales@chemegen.com
- Country
- China
- ProdList
- 11289
- Advantage
- 58
- Tel
- 15869524721
- 3525679403@qq.com
- Country
- China
- ProdList
- 3614
- Advantage
- 58
- Tel
- 021-58432009 400-005-6266
- Fax
- 021-58436166
- marketing1@energy-chemical.com
- Country
- China
- ProdList
- 44843
- Advantage
- 58
- Tel
- 021-69568360 18916172912
- order@med-bio.cn
- Country
- China
- ProdList
- 8141
- Advantage
- 58
- Tel
- 0519-85524369
- 3477467573@qq.com
- Country
- China
- ProdList
- 8618
- Advantage
- 58
- Tel
- 021-50967598 02150967598
- sales@abmole.cn
- Country
- China
- ProdList
- 4495
- Advantage
- 58
- Tel
- 0371-65741762
- Fax
- QQ:2860768577
- sales@hasunny.com
- Country
- China
- ProdList
- 2380
- Advantage
- 58
- Tel
- 4008200310
- marketing@tsbiochem.com
- Country
- China
- ProdList
- 24017
- Advantage
- 58
- Tel
- 0512-65118909 15162312715
- sales@szzxbio.com
- Country
- China
- ProdList
- 2992
- Advantage
- 58
- Tel
- 025-85560043 15850508050
- Fax
- 025-85563444
- cindy.huang@synzest.com
- Country
- China
- ProdList
- 12007
- Advantage
- 58
- Tel
- +86-18521732826
- market@aladdin-e.com
- Country
- China
- ProdList
- 48467
- Advantage
- 58
- Tel
- 18024082417
- market@ubiochem.com
- Country
- China
- ProdList
- 9180
- Advantage
- 58
- Tel
- +undefined-21-51877795
- Fax
- +86 21 5161 9052/ 5187 7796
- ivan@atkchemical.com
- Country
- China
- ProdList
- 32715
- Advantage
- 60
- Tel
- --
- Fax
- --
- yihbio@163.com
- Country
- CHINA
- ProdList
- 5668
- Advantage
- 58
- Tel
- --
- Fax
- --
- 978560024@qq.com
- Country
- CHINA
- ProdList
- 6011
- Advantage
- 58
- Tel
- --
- Fax
- --
- 1920192055@qq.com
- Country
- CHINA
- ProdList
- 1843
- Advantage
- 58
- Tel
- --
- Fax
- --
- chenjw@absin.cn
- Country
- CHINA
- ProdList
- 6661
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@wheybio.com
- Country
- CHINA
- ProdList
- 4398
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@qwbio.com
- Country
- China
- ProdList
- 6912
- Advantage
- 50
- Tel
- --
- Fax
- --
- 1985563437@qq.com
- Country
- CHINA
- ProdList
- 6172
- Advantage
- 58
- Tel
- --
- Fax
- --
- WHIGA22@126.COM
- Country
- CHINA
- ProdList
- 6748
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@zzsrm.com
- Country
- CHINA
- ProdList
- 6846
- Advantage
- 58