ChemicalBook > CAS DataBase List > 1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea

1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea

Product Name
1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea
CAS No.
1384424-80-9
Chemical Name
1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea
Synonyms
A-1070722;A 1070722, 10 mM in DMSO;N-(7-Methoxy-4-quinolinyl)-N’-[6-(trifluoromethyl)-2-pyridinyl]urea;1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea;N-(7-Methoxy-4-quinolinyl)-N'-[6-(trifluoromethyl)-2-pyridinyl]urea;Urea, N-(7-methoxy-4-quinolinyl)-N'-[6-(trifluoromethyl)-2-pyridinyl]-;A 1070722,Glycogen synthase kinase-3,inhibit,A1070722,Inhibitor,GSK-3,Glycogen synthase kinase 3,A-1070722
CBNumber
CB12751082
Molecular Formula
C17H13F3N4O2
Formula Weight
362.31
MOL File
1384424-80-9.mol
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1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea Property

Boiling point:
412.5±45.0 °C(Predicted)
Density 
1.461±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: soluble15mg/mL, clear
pka
11.57±0.43(Predicted)
form 
powder
color 
white to beige
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Safety

Hazard Codes 
T
Risk Statements 
25-36/37/38
Safety Statements 
36/37/39-45
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0863
Product name
A-1070722
Purity
≥98% (HPLC)
Packaging
5mg
Price
$123
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0863
Product name
A-1070722
Purity
≥98% (HPLC)
Packaging
25mg
Price
$425
Updated
2022/05/15
Cayman Chemical
Product number
29783
Product name
A-1070722
Packaging
5mg
Price
$100
Updated
2024/03/01
Cayman Chemical
Product number
29783
Product name
A-1070722
Packaging
25mg
Price
$343
Updated
2024/03/01
Cayman Chemical
Product number
29783
Product name
A-1070722
Packaging
1mg
Price
$32
Updated
2024/03/01
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1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea Chemical Properties,Usage,Production

Description

A-1070722 is an inhibitor of glycogen synthase kinase 3β (GSK3β; IC50 = <100 nM).

Uses

N-(7-Methoxy-4-quinolinyl)-N''-[6-(trifluoromethyl)-2-pyridinyl]urea is a neuroprotective agent and a glycogen synthase kinase-3 (GSK-3) inhibitor. GSK-3 is a conserved signaling enzyme that regulates a wide range of biological events (apoptosis, synaptic plasticity, axon formation, and neurogenesis). The enzyme has a conserved catalytic domain for binding ATP and a C-terminal domain with a conserved activation loop for the kinase activity. GSK-3 is a therapeutic target for treating neurodegenerative and psychiatric disorders.

storage

Store at RT

1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea Suppliers

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1384424-80-9, 1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]ureaRelated Search:


  • 1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea
  • A-1070722
  • Urea, N-(7-methoxy-4-quinolinyl)-N'-[6-(trifluoromethyl)-2-pyridinyl]-
  • -[6-(trifluoromethyl)-2-pyridinyl]urea
  • N-(7-Methoxy-4-quinolinyl)-N&rsquo
  • N-(7-Methoxy-4-quinolinyl)-N'-[6-(trifluoromethyl)-2-pyridinyl]urea
  • A 1070722,Glycogen synthase kinase-3,inhibit,A1070722,Inhibitor,GSK-3,Glycogen synthase kinase 3,A-1070722
  • A 1070722, 10 mM in DMSO
  • 1384424-80-9