4-IODO-1-METHYL-1H-PYRAZOLE-3-CARBOXYLIC ACID
- Product Name
- 4-IODO-1-METHYL-1H-PYRAZOLE-3-CARBOXYLIC ACID
- CAS No.
- 6647-98-9
- Chemical Name
- 4-IODO-1-METHYL-1H-PYRAZOLE-3-CARBOXYLIC ACID
- Synonyms
- AKOS B000136;ART-CHEM-BB B000136;4-iodo-1-methylpyrazole-3-carboxylic acid;4-IODO-1-METHYL-1H-PYRAZOLE-3-CARBOXYLIC ACID;4-Iodo--1-methyl-1H-pyrazol-3-carboxylic acid;1H-Pyrazole-3-carboxylic acid, 4-iodo-1-methyl-
- CBNumber
- CB1284663
- Molecular Formula
- C5H5IN2O2
- Formula Weight
- 252.01
- MOL File
- Mol file
4-IODO-1-METHYL-1H-PYRAZOLE-3-CARBOXYLIC ACID Property
- Melting point:
- 256-257 °C
- Boiling point:
- 362.2±27.0 °C(Predicted)
- Density
- 2.26±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- pka
- 2.71±0.10(Predicted)
- Appearance
- White to off-white Solid
Safety
- Hazard Codes
- Xi
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P403Store in a well-ventilated place.
N-Bromosuccinimide Price
- Product number
- R432741
- Product name
- 4-IODO-1-METHYL-1H-PYRAZOLE-3-CARBOXYLIC ACID
- Purity
- Aldrich<sup>CPR</sup>
- Packaging
- 1 unit
- Price
- $30.7
- Updated
- 2025/07/31
- Product number
- R432741
- Product name
- 4-IODO-1-METHYL-1H-PYRAZOLE-3-CARBOXYLIC ACID
- Purity
- AldrichCPR
- Packaging
- 50MG
- Price
- $29.8
- Updated
- 2024/03/01
- Product number
- AK109851
- Product name
- 4-Iodo-1-methyl-1H-pyrazole-3-carboxylicacid
- Purity
- 95+%
- Packaging
- 1g
- Price
- $53
- Updated
- 2021/12/16
- Product number
- 027389
- Product name
- 4-Iodo-1-methyl-1H-pyrazole-3-carboxylic acid
- Packaging
- 500mg
- Price
- $252
- Updated
- 2021/12/16
- Product number
- A263384
- Product name
- 4-Iodo-1-methyl-1H-pyrazole-3-carboxylicacid
- Purity
- 95+%
- Packaging
- 100mg
- Price
- $19
- Updated
- 2021/12/16
4-IODO-1-METHYL-1H-PYRAZOLE-3-CARBOXYLIC ACID Chemical Properties,Usage,Production
Synthesis
179692-08-1
74-88-4
6647-98-9
General procedure for the synthesis of 4-iodo-1-methyl-1H-pyrazole-3-carboxylic acid from ethyl 4-iodo-1H-pyrazole-3-carboxylate and iodomethane: NaH (60% dispersion in mineral oil, 0.72 g, 18 mmol, 1.2 eq.) was added batchwise to ethyl 4-iodo-1H-pyrazole-3-carboxylate (4.2 g, 15 mmol, 1.0 eq.) in a The mixture was again cooled to 0 °C and iodomethane (1.0 mL, 16.5 mmol, 1.1 eq.) was slowly added. After the reaction mixture solidified, the cold bath was removed and the reaction was continued for 1 h at room temperature. The progress of the reaction was monitored by analytical HPLC to confirm complete consumption of the feedstock and then the reaction was quenched by the slow addition of water (0.5 mL) followed by the slow addition of 2 M NaOH solution (1.0 equiv) under stirring. The reaction mixture was stirred at room temperature until the ester groups were completely hydrolyzed (1-2 hours). The light yellow suspension was filtered and the yellow solid product was collected. The filtrate was concentrated under vacuum and washed with hexane to remove the mineral oil. The aqueous layer and the solid product were combined and the pH was adjusted to 12 with 6N HCl. The aqueous layer was extracted with EtOAc (3 times), the organic phases were combined, washed with brine, dried over anhydrous Na2SO4, and concentrated to give 4-iodo-1-methyl-1H-pyrazole-3-carboxylic acid as a light yellow solid, which can be used without further purification.
References
[1] Patent: WO2017/139603, 2017, A1. Location in patent: Page/Page column 94
4-IODO-1-METHYL-1H-PYRAZOLE-3-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-IODO-1-METHYL-1H-PYRAZOLE-3-CARBOXYLIC ACID manufacturers
- Product
- 4-iodo-1-methylpyrazole-3-carboxylic acid 6647-98-9
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-08-07