2-(AMINOMETHYL)-18-CROWN-6 Property

Boiling point:

135 °C/0.08 mmHg (lit.)

Density 

1.126 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.479(lit.)

Flash point:

113 °C

pka

9.11±0.29(Predicted)

BRN 

4184588

Safety

Hazard Codes 

Xn

Risk Statements 

20/21/22-36/37/38

Safety Statements 

26-36

WGK Germany 

3

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

2-(AMINOMETHYL)-18-CROWN-6 Chemical Properties,Usage,Production

Uses

2-Aminomethyl-18-crown-6 (AM-18-C-6) can be used to prepare:

• AM-18-C-6 bonded Merrifield peptide resin, which is used to study the absorption and the isotopic effect of magnesium.
• Schiff base of gossypol with aminomethyl crown ether for complexation of monovalent cations.
• Crown tagged triarylphosphine by reacting with triphenylphosphine carboxylic acid. These tagged triarylphosphine reagents are used in Mitsunobu and Heck reactions for the removal of phosphine derived by-products.
• 1,16-hexadecanoyl-bis-(2-aminomethyl)-18-crown-6 (bola A-16), which is utilized as a vesicular carrier in a drug delivery system.