ChemicalBook > CAS DataBase List > 3-(3,4-DIMETHOXY-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER

3-(3,4-DIMETHOXY-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER

Product Name
3-(3,4-DIMETHOXY-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER
CAS No.
4687-37-0
Chemical Name
3-(3,4-DIMETHOXY-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER
Synonyms
Ethyl veratroylacetate;ETHYL 3,4-DIMETHOXYBENZOYLACETATE;Ethyl 3,4-diMethoxybenzoylacetate 97%;Ethyl 3,4-dimethoxy-β-oxobenzenepropanoate;Ethyl 3-oxo-3-(3,4-dimethoxyphenyl)propanoate;ETHYL 3-(3,4-DIMETHOXYPHENYL)-3-OXOPROPANOATE;Benzenepropanoicacid, 3,4-dimethoxy-b-oxo-, ethyl ester;Benzenepropanoic acid, 3,4-dimethoxy-β-oxo-, ethyl ester;3-(3,4-DIMETHOXY-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER
CBNumber
CB1294000
Molecular Formula
C13H16O5
Formula Weight
252.26
MOL File
4687-37-0.mol
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3-(3,4-DIMETHOXY-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER Property

Melting point:
37-41 °C (lit.)
Boiling point:
150-160 °C(Press: 0.01 Torr)
Density 
1.136±0.06 g/cm3(Predicted)
Flash point:
>230 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
pka
10.77±0.48(Predicted)
Appearance
Colorless to light yellow <37°C Solid,>41°C Liquid
CAS DataBase Reference
4687-37-0(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
36
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
593168
Product name
Ethyl 3,4-dimethoxybenzoylacetate
Purity
97%
Packaging
5g
Price
$176
Updated
2025/07/31
Sigma-Aldrich
Product number
593168
Product name
Ethyl 3,4-dimethoxybenzoylacetate
Purity
97%
Packaging
1g
Price
$73.8
Updated
2023/06/20
Biosynth Carbosynth
Product number
FD146095
Product name
Ethyl 3-(3,4-Dimethoxyphenyl)-3-oxopropanoate
Packaging
1g
Price
$80
Updated
2021/12/16
AK Scientific
Product number
6402AB
Product name
Ethyl3-(3,4-dimethoxyphenyl)-3-oxopropanoate
Packaging
1g
Price
$114
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD146095
Product name
Ethyl 3-(3,4-Dimethoxyphenyl)-3-oxopropanoate
Packaging
2g
Price
$128
Updated
2021/12/16
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3-(3,4-DIMETHOXY-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER Chemical Properties,Usage,Production

Synthesis

1131-62-0

105-58-8

4687-37-0

GENERAL STEPS: The synthesis of ethyl 3,4-dimethoxybenzoylacetate from 3,4-dimethoxyacetophenone and diethyl carbonate was carried out as follows: first, 3,4-dimethoxyacetophenone (0.05 mol) was dissolved in toluene (50 mL) and then added slowly and dropwise to a solution containing diethyl carbonate (0.10 mol) and sodium hydride (0.15 mol, 60% mineral oil dispersion) (0.15 mol, 60% mineral oil dispersion). The reaction mixture was stirred at room temperature and heated to reflux for 30 minutes. Upon completion of the reaction, the mixture was poured into ice water, acidified with glacial acetic acid and subsequently extracted with ethyl acetate (3 x 100 mL). The organic phases were combined and dried with anhydrous magnesium sulfate. After removal of solvent by distillation under reduced pressure, the crude product was purified by silica gel column chromatography using dichloromethane as eluent to afford the target product ethyl 3,4-dimethoxybenzoylacetate. All the synthesized compounds were subjected to structural confirmation by 1H NMR, 13C NMR, IR and mass spectrometry.

References

[1] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 17, p. 5064 - 5075
[2] Heterocycles, 1979, vol. 13, p. 239 - 246
[3] Journal of Medicinal Chemistry, 1997, vol. 40, # 20, p. 3217 - 3227
[4] Patent: JP2005/82549, 2005, A. Location in patent: Page/Page column 19-20
[5] Angewandte Chemie - International Edition, 2011, vol. 50, # 32, p. 7304 - 7307

3-(3,4-DIMETHOXY-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-(3,4-DIMETHOXY-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
3-(3,4-DIMETHOXY-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER 4687-37-0
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 mt
Release date
2024-12-04
Shaanxi Dideu Medichem Co. Ltd
Product
Ethyl 3,4-diMethoxybenzoylacetate 4687-37-0
Price
US $1.00-22.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100000KG
Release date
2024-08-06
Zhuozhou Wenxi import and Export Co., Ltd
Product
3-(3,4-DIMETHOXY-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER 4687-37-0
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11

4687-37-0, 3-(3,4-DIMETHOXY-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTERRelated Search:

6,7-DIMETHOXY-4-OXO-1,4-DIHYDRO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER Ethyl 3,4,5-trimethoxybenzoylacetate Ethyl 2,3-dihydro-5,6-dimethoxy-1-oxo-1H-indene-2-carboxylate 3-OXO-3-(2,3,4-TRIMETHOXYPHENYL)PROPIONIC ACID ETHYL ESTER Quincarbate 3-(3,4-DIMETHOXY-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER ETHYL 3-(4-(BENZYLOXY)-3-METHOXYPHENYL)-3-OXOPROPANOATE ethyl [3,4-(ethylenedioxy)benzoyl]acetate 3-(2,3-DIMETHOXY-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER 3-(3,5-DIMETHOXY-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER 3-(2,4-DIMETHOXY-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER 3-(2,5-DIMETHOXY-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER 2-(4-NITRO-PHENYL)-3-OXO-3-(2,4,5-TRIMETHOXY-PHENYL)-PROPIONIC ACID ETHYL ESTER AKOS BC-1956 AURORA 17731 2-(4-NITRO-PHENYL)-3-OXO-3-(3,4,5-TRIMETHOXY-PHENYL)-PROPIONIC ACID ETHYL ESTER diethyl (3,4,5-trimethoxybenzoyl)malonate 2-CYANO-3-(3,4-DIMETHOXY-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER

  • 3-(3,4-DIMETHOXY-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER
  • ETHYL 3-(3,4-DIMETHOXYPHENYL)-3-OXOPROPANOATE
  • ETHYL 3,4-DIMETHOXYBENZOYLACETATE
  • Ethyl 3,4-diMethoxybenzoylacetate 97%
  • Ethyl 3-oxo-3-(3,4-dimethoxyphenyl)propanoate
  • Ethyl veratroylacetate
  • Benzenepropanoic acid, 3,4-dimethoxy-β-oxo-, ethyl ester
  • Benzenepropanoicacid, 3,4-dimethoxy-b-oxo-, ethyl ester
  • Ethyl 3,4-dimethoxy-β-oxobenzenepropanoate
  • 4687-37-0
  • C2H5OCOCH2COC6H3OCH32
  • Building Blocks
  • Carbonyl Compounds
  • C12 to C63
  • Organic Building Blocks
  • Esters
  • C12 to C63
  • Carbonyl Compounds
  • Esters