4-METHYL-3,4-DIHYDRO-2H-1,4-BENZOXAZINE-7-CARBALDEHYDE

Product Name: 4-METHYL-3,4-DIHYDRO-2H-1,4-BENZOXAZINE-7-CARBALDEHYDE
CAS No.: 141103-93-7
Chemical Name: 4-METHYL-3,4-DIHYDRO-2H-1,4-BENZOXAZINE-7-CARBALDEHYDE
Synonyms: 3,4-Dihydro-7-formyl-4-methyl-2H-1,4-benzoxazine;4-methyl-2,3-dihydro-1,4-benzoxazine-7-carbaldehyde;4-METHYL-3,4-DIHYDRO-2H-1,4-BENZOXAZINE-7-CARBALDEHYDE;4-Methyl-2,3-dihydro-2H-1,4-benzoxazine-7-carbaldehyde;3,4-Dihydro-4-methyl-2H-1,4-benzoxazine-7-carboxaldehyde;4-METHYL-3,4-DIHYDRO-2H-1,4-BENZOXAZINE-7-CARBOXALDEHYDE;4-Methyl-3,4-dihydro-2H-benzo[1,4]oxazine-7-carbaldehyde;2H-1,4-Benzoxazine-7-carboxaldehyde, 3,4-dihydro-4-methyl-;4-Methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carbaldehyde
CBNumber: CB1296165
Molecular Formula: C10H11NO2
Formula Weight: 177.2
MOL File: 141103-93-7.mol

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4-METHYL-3,4-DIHYDRO-2H-1,4-BENZOXAZINE-7-CARBALDEHYDE Property

Boiling point:: 336.5±42.0 °C(Predicted)
Density: 1.181±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 2.57±0.20(Predicted)
Appearance: Light yellow to yellow Solid
CAS DataBase Reference: 141103-93-7

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Safety

Risk Statements: 36/37/38-52
Safety Statements: 26-36/37/39
HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: M507520
Product name: 4-Methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carbaldehyde
Packaging: 10mg
Price: $45
Updated: 2021/12/16

Apolloscientific

Product number: OR23219
Product name: 3,4-Dihydro-4-methyl-2H-1,4-benzoxazine-7-carboxaldehyde
Packaging: 250mg
Price: $73
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H15-1-X2
Product name: 3,4-Dihydro-4-methyl-2H-1,4-benzoxazine-7-carboxaldehyde
Packaging: 250mg
Price: $80
Updated: 2021/12/16

AK Scientific

Product number: Y7502
Product name: 4-Methyl-3,4-dihydro-2H-1,4-benzoxazine-7-carbaldehyde
Packaging: 250mg
Price: $149
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H15-1-X2
Product name: 3,4-Dihydro-4-methyl-2H-1,4-benzoxazine-7-carboxaldehyde
Packaging: 1g
Price: $160
Updated: 2021/12/16

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4-METHYL-3,4-DIHYDRO-2H-1,4-BENZOXAZINE-7-CARBALDEHYDE Chemical Properties,Usage,Production

Synthesis

68-12-2

154264-95-6

141103-93-7

The general procedure for the synthesis of 4-methyl-3,4-dihydro-2H-1,4-benzoxazine-7-carbaldehyde from N,N-dimethylformamide and 7-bromo-4-methyl-3,4-dihydro-2H-1,4-benzoxazine was as follows: n-butyllithium (5.79 mL, 14.47 mmol) was slowly added to a stirring 7-bromo-4-methyl-3,4 -dihydro-2H-1,4-benzoxazine (Int-81a, 3 g, 13.15 mmol) in a solution of tetrahydrofuran (24 mL). After keeping stirring at -78 °C for 1 h, N,N-dimethylformamide (2.037 mL, 26.3 mmol) was slowly added dropwise, followed by allowing the reaction mixture to gradually warm up to room temperature over a period of 2 hours. Upon completion of the reaction, the reaction was quenched with aqueous ammonium chloride and the product was extracted with ethyl acetate. The organic phases were combined, washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to afford the target product Int-81b (4-methyl-3,4-dihydro-2H-1,4-benzoxazine-7-carbaldehyde, 2.32 g, 13.09 mmol, 100% yield) as a green solid.

References

[1] Patent: WO2012/41014, 2012, A1. Location in patent: Page/Page column 236-237

4-METHYL-3,4-DIHYDRO-2H-1,4-BENZOXAZINE-7-CARBALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-METHYL-3,4-DIHYDRO-2H-1,4-BENZOXAZINE-7-CARBALDEHYDE Suppliers

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View Lastest Price from 4-METHYL-3,4-DIHYDRO-2H-1,4-BENZOXAZINE-7-CARBALDEHYDE manufacturers

Career Henan Chemical Co

Product: 4-METHYL-3,4-DIHYDRO-2H-1,4-BENZOXAZINE-7-CARBALDEHYDE 141103-93-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 100kg
Release date: 2020-01-14

141103-93-7, 4-METHYL-3,4-DIHYDRO-2H-1,4-BENZOXAZINE-7-CARBALDEHYDERelated Search:

RARECHEM AL BF 1316 4-METHYL-3,4-DIHYDRO-2H-1,4-BENZOXAZINE-7-CARBALDEHYDE RARECHEM AL BI 1316 (E)-7-(1-Oxo-3-phenyl-2-propenyl)-2,2,4-trimethyl-2H-1,4-benzoxazin-3( 4H)-one 4-methyl-7-(2-methylene-1-oxobutyl)-2H-1,4-benzoxazin-3(4H)-one 2,4-dimethyl-7-(2-methylene-1-oxobutyl)-2H-1,4-benzoxazin-3(4H)-one 4-METHYL-3,4-DIHYDRO-2H-1,4-BENZOXAZINE-7-CARBONYL CHLORIDE 4-METHYL-3,4-DIHYDRO-2H-1,4-BENZOXAZINE-7-CARBOXYLIC ACID

4-METHYL-3,4-DIHYDRO-2H-1,4-BENZOXAZINE-7-CARBALDEHYDE

4-METHYL-3,4-DIHYDRO-2H-1,4-BENZOXAZINE-7-CARBOXALDEHYDE

3,4-Dihydro-4-methyl-2H-1,4-benzoxazine-7-carboxaldehyde

3,4-Dihydro-7-formyl-4-methyl-2H-1,4-benzoxazine

4-Methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carbaldehyde

4-Methyl-2,3-dihydro-2H-1,4-benzoxazine-7-carbaldehyde

4-Methyl-3,4-dihydro-2H-benzo[1,4]oxazine-7-carbaldehyde

2H-1,4-Benzoxazine-7-carboxaldehyde, 3,4-dihydro-4-methyl-

4-methyl-2,3-dihydro-1,4-benzoxazine-7-carbaldehyde

141103-93-7

ALDEHYDE