4,4'-(Hexafluoroisopropylidene)diphthalic anhydride

Product Name: 4,4'-(Hexafluoroisopropylidene)diphthalic anhydride
CAS No.: 1107-00-2
Chemical Name: 4,4'-(Hexafluoroisopropylidene)diphthalic anhydride
Synonyms: 6FDA;HFDA;2,2-bis(3,4-;DAIKIN YZ0002;6f-dianhydride;High purity 6FDA;4,4'-(Hexafluoroisop;6f-dianhydride(6FDA);Hexafluorodianhydride;uoropropane dianhydride
CBNumber: CB1298806
Molecular Formula: C19H6F6O6
Formula Weight: 444.24
MOL File: 1107-00-2.mol

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4,4'-(Hexafluoroisopropylidene)diphthalic anhydride Property

Melting point:: 244-247 °C(lit.)
Boiling point:: 494.5±45.0 °C(Predicted)
Density: 1.697±0.06 g/cm3(Predicted)
vapor pressure: 7.7Pa at 20℃
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: powder to crystal
color: White to Almost white
Water Solubility: Miscible with water.
Sensitive: Moisture Sensitive
BRN: 7057916
InChI: InChI=1S/C19H6F6O6/c20-18(21,22)17(19(23,24)25,7-1-3-9-11(5-7)15(28)30-13(9)26)8-2-4-10-12(6-8)16(29)31-14(10)27/h1-6H
InChIKey: QHHKLPCQTTWFSS-UHFFFAOYSA-N
SMILES: C(C1C=CC2C(=O)OC(=O)C=2C=1)(C1C=CC2C(=O)OC(=O)C=2C=1)(C(F)(F)F)C(F)(F)F
LogP: 5.59 at 25℃
CAS DataBase Reference: 1107-00-2(CAS DataBase Reference)
EPA Substance Registry System: 1,3-Isobenzofurandione, 5,5'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]bis- (1107-00-2)

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Safety

Hazard Codes: C,Xi
Risk Statements: 34
Safety Statements: 26-36/37/39-45
RIDADR: UN 3261 8/PG 2
WGK Germany: 1
F: 21
Hazard Note: Irritant
TSCA: T
HazardClass: 8
PackingGroup: II
HS Code: 29173990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 386448
Product name: 4,4′-(Hexafluoroisopropylidene)diphthalic anhydride
Purity: 99%
Packaging: 5g
Price: $91.9
Updated: 2025/07/31

Sigma-Aldrich

Product number: 386448
Product name: 4,4′-(Hexafluoroisopropylidene)diphthalic anhydride
Purity: 99%
Packaging: 25g
Price: $350
Updated: 2025/07/31

TCI Chemical

Product number: H0771
Product name: 4,4'-(Hexafluoroisopropylidene)diphthalic Anhydride
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $42
Updated: 2025/07/31

TCI Chemical

Product number: H0771
Product name: 4,4'-(Hexafluoroisopropylidene)diphthalic Anhydride
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $144
Updated: 2025/07/31

TCI Chemical

Product number: H1438
Product name: 4,4'-(Hexafluoroisopropylidene)diphthalic Anhydride (purified by sublimation)
Purity: >99.0%(GC)
Packaging: 1g
Price: $28
Updated: 2025/07/31

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4,4'-(Hexafluoroisopropylidene)diphthalic anhydride Chemical Properties,Usage,Production

Description

4,4'-(Hexafluoroisopropylidene)diphthalic anhydride (6FDA) is an aromatic organofluorine compound that is utilized as a dianhydride monomer. It is among the most frequently used dianhydride monomers due to its exceptional balance of mechanical and electrical properties. It is particularly prominent in the construction of colorless and transparent polyimides.

Physical properties

Beige crystal

Uses

4,4'-(Hexafluoroisopropylidene) diphthalic anhydride is involved in the synthesis of polyamides derived from terphenylenes, which is used for gas separation.

Application

4,4'-(Hexafluoroisopropylidene)diphthalic anhydride (6FDA) can be used:
(1) With APAF as dianhydride monomer, it can be used to prepare thermally rearranged polybenzoxazole (TR-PBO) gas separation membranes by thermal rearrangement reaction at 450°C. The product TR-PBO membrane has excellent gas permeation selectivity and high permeability. the H2/CH4 separation performance of APAF-6FDA membrane is close to the Robertson upper limit of 2008^[5].
(2) Used as a raw material for the preparation of thermoplastic fluorinated polyimide resin.^[6].
(3) Polymers for electronic materials;
(4) Polyimide materials. These materials can be used as substrates for wearable devices and as multilayer insulation materials in order to protect against space dust, cosmic rays and satellite debris^[7].

General Description

4,4'-(Hexafluoroisopropylidene)diphthalic anhydride (6FDA) consists of two phthalic anhydrides bridged with a perfluoroisopropyl group and is mainly used in the synthesis of polyimides. Polyimides from 6FDA are commonly used in hybrid matrix membranes. The polyimide matrix provides good dispersion of the filler and can be loaded with up to 50 wt% filler. These membranes have been used for highly selective gas separation (CO2/CH4) and solar cell encapsulation (power conversion efficiency of silicon-based solar cells increased from 14.67% to 15.64%).

Synthesis

108-24-7

65294-20-4

1107-00-2

The general procedure for the synthesis of hexafluorodianhydride (6FDA) from ethanoic anhydride and 2,2-bis(3,4-dimethylphenyl)hexafluoropropane was as follows: in a 2000 mL three-necked flask, 14.40 g of 4,4'-(hexafluoroisopropylidene)bis(o-xylene) and solvent mixture of pyridine (200 mL) and water (100 mL) were added. The mixture was heated to 100 °C and then 38.0 g of potassium permanganate was added slowly and the reaction was maintained for 3 hours. Upon completion of the reaction, a small amount of ethanol was added dropwise to quench the unreacted potassium permanganate. The reaction mixture was filtered and the pyridine was subsequently recovered from the filtrate by distillation. The pH of the remaining solution was adjusted to 1 and water was removed to dryness by evaporation. 320 mL of acetone was added to dissolve the organic material, and after filtration to remove insoluble material, the filtrate was evaporated to dryness to give hexafluorobutyric acid in 80% yield. A mixture of 4.80 g of hexafluorobutyric acid with 8 mL of acetic anhydride and 8 mL of xylene was added to a 150 mL flask and reacted at 140 °C for 40 min. After completion of the reaction, the crude product was cooled and filtered to obtain hexafluorodianhydride (6FDA) crude product. After purification by sublimation and drying, hexafluorodianhydride (6FDA) with purity greater than 99.5% was obtained in 79% yield.

Advantages

The 4,4'-(hexafluoroisopropylidene) diphthalic anhydride (6FDA) monomer contains rigid benzene ring groups, and so, the resulting polymer has excellent mechanical properties. 6FDA contained a stable benzene ring and fluorine atoms. Due to the strong electronegativity of the fluorine atoms and the stability of the benzene ring, the produced polycarbonate had better thermal stability[1-2].

Precautions

The storage precautions for 6FDA are as follows: The chemical must be stored in a cool and well-ventilated warehouse, away from sources of heat and fire. Proper sealing is required to prevent contact with air, and it should always be kept separate from oxidants, edible chemicals, and acids. The storage area should have explosion-proof lighting and ventilation facilities and must not allow any mechanical equipment or tools that may cause sparks to prevent accidents. Leakage emergency treatment equipment and suitable storage materials must be readily available in the storage area.

References

[1] Yile Zhang. “Poly(propylene carbonate) networks with excellent properties: Terpolymerization of carbon dioxide, propylene oxide, and 4,4?-(hexafluoroisopropylidene) diphthalic anhydride.” e-Polymers 21 1 (2021): 511–519.
[2] C. D. Simone, D. A. Scola. “Phenylethynyl End-Capped Polyimides Derived from 4,4‘-(2,2,2-Trifluoro-1-phenylethylidene)diphthalic Anhydride, 4,4‘-(Hexafluoroisopropylidene)diphthalic Anhydride, and 3,3‘,4,4‘-Biphenylene Dianhydride: Structure?Viscosity Relationship.” Macromolecules 36 18 (2003): 6780–6790.
[3] MARYANNE MORES Patrick E C. Polyimidines. XI. Polyimidines from 3,3′,4,4′-benzophenonetetracarboxylic dianhydride and 4,4′-(hexafluoroisopropylidene) diphthalic anhydride[J]. Journal of Polymer Science Part A: Polymer Chemistry, 1990, 28 4: 811-823. DOI:10.1002/pola.1990.080280410.
[4] HUI WU Hezhou L Hua Li. Synthesis and Properties of a High-Molecular-Weight Polyimide Based on 4, 4’-(hexafluoroisopropylidene) Diphthalic Anhydride[J]. Advanced Materials Research, 2012, 35 1: 742-746. DOI:10.4028/www.scientific.net/AMR.550-553.742.
[5] XU LIU. Molecular design of free volume structure in thermally rearranged polybenzoxazole membranes for gas separation studied by positron annihilation[J]. Journal of Polymer Science, 2024. DOI:10.1002/pol.20240229.
[6] GAOJIE WU. Design and preparation of thermoplastic polyimides with high transmittance based on 4,4′-(4,4′-isopropyldiphenoxy)bis(phthalic anhydride) (BPADA)[J]. European Polymer Journal, 2023. DOI:10.1016/j.eurpolymj.2022.111798.
[7] YOUNG NAM KIM, YONG CHAE JUNG* Challenge for Trade-Off Relationship between the Mechanical Property and Healing Efficiency of Self-Healable Polyimide[J]. ACS Applied Materials & Interfaces, 2023. DOI:10.1021/acsami.3c12594.

4,4'-(Hexafluoroisopropylidene)diphthalic anhydride Preparation Products And Raw materials

Raw materials

Preparation Products

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4,4'-(Hexafluoroisopropylidene)diphthalic anhydride Suppliers

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CHINATECH(TIANJIN) CHEMICAL CO.,LTD.

Product: 4,4'-(Hexafluoroisopropylidene) diphthalic anhydride (6FDA) 1107-00-2
Price: US $0.00-0.00/Kg
Min. Order: 1Kg
Purity: ≥99.9%HPLC
Supply Ability: 200MT
Release date: 2025-10-24

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 4,4'-(Hexafluoroisopropylidene)diphthalic anhydride 1107-00-2
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-02-24

Speranza Chemical Co., Ltd.

Product: 4,4'-(Hexafluoroisopropylidene)diphthalic anhydride 1107-00-2
Price: US $25.00/KG
Min. Order: 1KG
Purity: 99%+
Supply Ability: 100MT/year
Release date: 2023-06-16

1107-00-2, 4,4'-(Hexafluoroisopropylidene)diphthalic anhydrideRelated Search:

4-tert-Butylphthalic anhydride 4-Ethylbenzoic acid Methyl 4-tert-butylbenzoate 2,5-Dimethylbenzoic acid 4-Methylphthalic anhydride 4-tert-Butylbenzaldehyde 2,2-Bis(4-methylphenyl)hexafluoropropane DI-P-TOLYLMETHANE METHYL 4-ISOPROPYLBENZOATE 4-Isopropylbenzoic acid 1,1,1,3,3,3-Hexafluoropropane 2,2-BIS(4-CARBOXYPHENYL)HEXAFLUOROPROPANE 4-TERT-BUTYL-O-XYLENE 2,4-Dimethylbenzoic acid 2,2-Bis(3,4-dimethylphenyl)hexafluoropropane Phthalic anhydride 4-TERT-BUTYLBENZYL ALCOHOL 4,4'-(Hexafluoroisopropylidene)diphthalic anhydride

4,4'-(Hexafluoroisop

[2,2,2-Trifluoro-1-(trifluoroMethyl)ethylidene]diphthalic anhydride

2,2-Bis(3,4-anhydrodicarboxyphenyl)-hexafluoropropane(6FDA)

2,2-Bis(1,3-dihydro-1,3-dioxobenzo[c]furan-5-yl)hexafluoropropane 99%

4,4'-(Hexafluoroisopropylidene)diphthalic anhydride, 5,5'-(1,1,1,3,3,3-Hexafluoropropane-2,2-diyl)bis(2-benzofuran-1,3-dione)

4,4'-(Hexafluoroisopropylidene)diphthalic anhydride SynonyMs 2,2-Bis(3,4-anhydrodicarboxyphenyl)hexafluoropropane

5,5'-(Perfluoropropane-2,2-diyl)bis(isobenzofuran-1,3-dione)

4,4'-(Hexafluoroisopropylidene)diphthalic anhydride(6FDA)

4,4'-(Hexafluoroisopropylidene)diphthalic Anhydride (purified by sublimation)

4,4,4'-(Hexafluoroisopropylidene)diphthalic anhydride (6FDA)

5-[2-(1,3-Dioxo-2-benzofuran-5-yl)-1,1,1,3,3,3-hexafluoropropan-2-yl]-2-benzofuran-1,3-dione

1,1,1,3,3,3-Hexafluoro-2,2-bis(1,3-dihydro-1,3-dioxoisobenzofuran-5-yl)propane

2,2-Bis(1,3-dihydro-1,3-dioxoisobenzofuran-5-yl)-1,1,1,3,3,3-hexafluoropropane

4,4'-(Hexafluoroisopropylidene)bisphthalic acid-1,2:1',2'-dianhydride

5,5'-(1,1,1,3,3,3-Hexafluoropropane-2,2-diyl)bis(1,3-isobenzofurandione)

5,5'-[2,2,2-Trifluoro-1-(trifluoromethyl)ethylidene]bis(1,3-isobenzofurandione)

2,2-Bis(1,3-dihydro-1,3-dioxobenzo[c]furan-5-yl)hex

2,2'-BIS(3,4-ANHYDRODICARBOXYLPHENYL)HEXAFLUOROPROPANE

2,2-BIS(3,4-ANHYDRODICARBOXYPHENYL)HEXAFLUOROPROPANE

5-[1-(1,3-dioxoisobenzofuran-5-yl)-2,2,2-trifluoro-1-(trifluoromethyl)ethyl]isobenzofuran-1,3-dione

4,4'-(Hexafluoroisopropylidene)diphthalic anhydride 1107-00-2 6FDA

2,2-Bis(3,4-anhydrodicarboxyphenyl)hexafluoropropane 1107-00-2 6FDA

HFDA

2,2-BIS(3,4-DICARBOXYPHENYL)-1,1,1,3,3,3-HEXAFLUOROPROPANE DIANHYDRIDE

2,2'-BIS-(3,4-DICARBOXYPHENYL)HEXAFLUOROPROPANE DIANHYDRIDE

4,4'-(HEXAFLUOROISOPROPYLIDENE)BIS-PHTHALIC ANHYDRIDE

6f-dianhydride

6FDA

DAIKIN YZ0002

4,4'-(Hexafluoroisopropylidene)diphthalic anhydride 99%

4,4'-(Hexafluoroisopropylidene)diphthalicanhydride99%

4,4′-(2,2,2-Trifluor-1-(trifluormethyl)ethyliden)diphthalsureanhydrid

4,4'-(Hexafluoroisopropylidene)diphthalic

4,4''-(Hexafluoroisopropylidene)-2,2-bis-(phthalic anhydride)

4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]diphthalic anhydride

HEXAFLUOROISOPROPYLIDENE-2,2-BISPHTHALIC ANHYDRIDE

2,2'-Bis(3,4-dicarboxyphenyL

uoropropane dianhydride

4,4’(Hexafluoroisopropylidene)Bisphthalic Dianhydride （6Fda）

4,4'-(Hexafluoroisopropylidene)diphthalicAnhydride&gt

4,4'-(Hexafluoroisopropylidene)diphthalicAnhydride(purifiedbysublimation)&gt

4,4'-(Hexafluoroisopropylidene)diphthalic anhydride, 99%, for synthesis

High purity 6FDA

4,4'-(Hexafluoroisopropylidene)diphthalicanhydride，98%

2,2-bis(3,4-

,4'-(Hexafluoroisopropylidene)diphthalic anhydride

,5'-(Hexafluoroisopropylidene)diphthalic anhydride

Hexafluorodianhydride (6FDA)

6f-dianhydride(6FDA)

2,2-Bis(3,4-anhydrodicarboxyphenyl)

6f-dianhydride,4，4，-（Hexafluoroisopropylidene）diphthalic anhydride

Hexafluorodianhydride

4,4'-(Hexafluoroisopropylidene

4,4'-(Hexafluoroisopropylidene) diphthalic anhydride(6FDA)

4,4'-(Hexafluoroisopropylidene)diphthalic anhydride

2,2-Bis(3,4-anhydrodicarboxypheny)-hexafluoropropane(6FDA)

1,3-Isobenzofurandione,5,5'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]bis-

Hexafluoroisopropylidene diphthalic anhydride (6FDA)