7-Benzylamino-4-nitrobenz-2-oxa-1,3-diazole

Product Name: 7-Benzylamino-4-nitrobenz-2-oxa-1,3-diazole
CAS No.: 18378-20-6
Chemical Name: 7-Benzylamino-4-nitrobenz-2-oxa-1,3-diazole
Synonyms: BBD;NSC240867;Benzylamino-NBD;BBD, 10 mM in DMSO;4-Benzylamino-7-nitr;triphenylstannanylium;4-Benzylamino-7-nitrobenzofurazan;4-Benzylamine-7-nitrobenzofurazan;7-Nitro-N-benzyl-4-benzofurazanamine;7-nitro-N-(benzyl)benzofurazan-4-amine
CBNumber: CB1301849
Molecular Formula: C13H10N4O3
Formula Weight: 270.24
MOL File: 18378-20-6.mol

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7-Benzylamino-4-nitrobenz-2-oxa-1,3-diazole Property

Melting point:: 206-209 °C
Boiling point:: 413.36°C (rough estimate)
Density: 1.2858 (rough estimate)
refractive index: 1.6120 (estimate)
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
solubility: Acetonitrile: Slightly Soluble: 0.1-1 mg/ml
DMSO: Slightly Soluble: 0.1-1 mg/ml
form: Solid
pka: -3.78±0.45(Predicted)
color: Brown to orange
CAS DataBase Reference: 18378-20-6

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 24/25-36-26
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B225085
Product name: 7-Benzylamino-4-nitrobenz-2-oxa-1,3-diazole
Packaging: 1g
Price: $880
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB142007
Product name: N-Benzyl-7-nitrobenzo[c][1,2,5]oxadiazol-4-amine
Packaging: 250mg
Price: $70
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB142007
Product name: N-Benzyl-7-nitrobenzo[c][1,2,5]oxadiazol-4-amine
Packaging: 500mg
Price: $120
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB142007
Product name: N-Benzyl-7-nitrobenzo[c][1,2,5]oxadiazol-4-amine
Packaging: 1g
Price: $212.5
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK361968
Product name: 4-Benzylamine-7-nitrobenzofurazan
Purity: 98%
Packaging: 1g
Price: $225
Updated: 2021/12/16

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7-Benzylamino-4-nitrobenz-2-oxa-1,3-diazole Chemical Properties,Usage,Production

Chemical Properties

BROWN FINE POWDER

Uses

BBD (NSC240867) is a biochemical reagent/chromogenic reagent.

Definition

ChEBI: 7-benzylamino-4-nitrobenz-2-oxa-1,3-diazole is a benzoxadiazole. It has a role as a fluorochrome.

Synthesis

10199-89-0

100-46-9

18378-20-6

GENERAL METHOD: To a solution of 4-chloro-7-nitrobenzo-2-oxa-1,3-diazole (NBD-Cl, 1 eq.) in acetonitrile (0.1 M) was added benzylamine (1.1 eq.) followed by triethylamine (2 eq.). The reaction mixture was stirred at reflux for 16 hours under nitrogen protection. Upon completion of the reaction, the solvent was removed by rotary evaporator under reduced pressure. The residue was redissolved in ethyl acetate, washed sequentially with 1 M hydrochloric acid, water and saturated saline, the organic phase was dried over anhydrous sodium sulfate, filtered and concentrated. The crude product was purified by silica gel column chromatography with gradient elution using ethyl acetate/hexane mixed solvent.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 1, p. 370 - 374
[2] Journal fuer Praktische Chemie (Leipzig), 1985, vol. 327, # 3, p. 487 - 504
[3] Journal of Medicinal Chemistry, 1968, vol. 11, # 2, p. 305 - 311
[4] R. A. KENNER A. A A. New fluorescent probe for protein and nucleoprotein conformation. Binding of 7-(p-methoxybenzylamino)-4-nitrobenzoxadiazole to bovine trypsinogen and bacterial ribosomes[J]. Biochemistry Biochemistry, 1971, 10 24: 4433-4440. DOI: 10.1021/bi00800a013
[5] SARAH A. STEVENSON G. J B. Dynamics of 4-Benzylamino-7-nitrobenzofurazan in the 1-Propanol/Water Binary Solvent System. Evidence for Composition-Dependent Solvent Organization[J]. The Journal of Physical Chemistry A, 2006, 110 10: 3426-3431. DOI: 10.1021/jp057039g
[6] Y MATSUSHITA I M M Takahashi. Binding of fluorescent 7-amino-4-nitrobenzoxadiazole derivatives to bovine serum albumin.[J]. Chemical & pharmaceutical bulletin, 1986, 34 1: 333-339. DOI: 10.1248/cpb.34.333

7-Benzylamino-4-nitrobenz-2-oxa-1,3-diazole Preparation Products And Raw materials

Raw materials

Preparation Products

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7-Benzylamino-4-nitrobenz-2-oxa-1,3-diazole Suppliers

Belgium 1 China 108 Germany 1 India 1 Japan 1 Switzerland 1 United Kingdom 3 United States 16 Global 132

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View Lastest Price from 7-Benzylamino-4-nitrobenz-2-oxa-1,3-diazole manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: BBD 18378-20-6
Price: US $2.20-8.80/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons
Release date: 2025-07-08

Career Henan Chemical Co

Product: 7-Benzylamino-4-nitrobenz-2-oxa-1,3-diazole 18378-20-6
Price: US $2.00/kg
Min. Order: 1kg
Purity: 9%
Supply Ability: 100kg
Release date: 2018-12-23

18378-20-6, 7-Benzylamino-4-nitrobenz-2-oxa-1,3-diazoleRelated Search:

Bifonazole Benzyl carbamate 2-Nitrobenzyl alcohol 2,1,3-BENZOXADIAZOL-4-AMINE BENZOFURAZAN MBD N-benzyl-4-nitroaniline 4-nitrobenzofurazan 7-Benzylamino-4-nitrobenz-2-oxa-1,3-diazole

BBD

BENZYLAMINO-4-NITROBENZ-2-OXA-1,3-DIAZOLE

4-BENZYLAMINO-7-NITROBENZ-2-OXA-1,3-DIAZOLE

7-BENZYLAMINO-4-NITROBENZ-2-OXA-1,3-DIAZOLE

4-Benzylamino-7-nitro-2,1,3-benzoxadiazole

BBD, 7-Benzylamino-4-nitrobenz-2-oxa-1,3-diazole

4-Benzofurazanamine, 7-nitro-N-(phenylmethyl)-

4-Nitro-N-(phenylmethyl)-2,1,3-benzoxadiazol-7-amine

4-(Benzylamino)-7-nitro-2,1,3-benzooxadiazole

7-Nitro-N-benzyl-4-benzofurazanamine

N-Benzyl-4-nitro-2,1,3-benzooxadiazole-7-amine

N-Benzyl-7-nitro-2,1,3-benzoxadiazole-4-amine

Benzylamino-NBD

7-nitro-N-(benzyl)benzofurazan-4-amine

4-BENZYLAMINO-7-NITROBENZOFURAZAN, FOR FLUORESCENCE*

7-BENZYLAMINO-4-NITROBENZ-2-OXA-1 3- &

4-Benzylamino-7-nitrobenzofurazan

N-Benzyl-7-nitrobenzo[c][1,2,5]oxadiazol-4-aMine

4-Benzylamine-7-nitrobenzofurazan, 98%

4-Benzylamino-7-nitr

4-BenzylaMino-7-nitro-2,1,3-benzoxadiazole (BBD)

2,1,3-Benzoxadiazol-4-amine,7-nitro-N-(phenylmethyl)-

triphenylstannanylium

NSC240867

BBD, 10 mM in DMSO

4-Benzylamine-7-nitrobenzofurazan

18378-20-6

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