tert-butyl N-[3,3-difluoro-1-(hydroxymethyl)cyclobutyl]carbamate

Product Name: tert-butyl N-[3,3-difluoro-1-(hydroxymethyl)cyclobutyl]carbamate
CAS No.: 1232365-42-2
Chemical Name: tert-butyl N-[3,3-difluoro-1-(hydroxymethyl)cyclobutyl]carbamate
Synonyms: DIFLUOROCYCLOBUTANE-1- METHANOL;1-(Boc-amino)-3,3-difluorocyclobutyl]methanol;1-(Boc-amino)-3,3-difluorocyclobutane-1-methanol;tert-Butyl (3,3-difluoro-1-(hydroxymethyl)cyclobutyl)carbamate;tert-butyl N-[3,3-difluoro-1-(hydroxymethyl)cyclobutyl]carbamate;Carbamic acid, N-[3,3-difluoro-1-(hydroxymethyl)cyclobutyl]-, 1,1-dimethylethyl ester
CBNumber: CB13033057
Molecular Formula: C10H17F2NO3
Formula Weight: 237.24
MOL File: 1232365-42-2.mol

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tert-butyl N-[3,3-difluoro-1-(hydroxymethyl)cyclobutyl]carbamate Property

storage temp.: 2-8°C
Appearance: yellow solid

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Safety

HS Code: 2924297099

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H320Causes eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B630205
Product name: 1-(Boc-amino)-3,3-difluorocyclobutane-1-methanol
Packaging: 10mg
Price: $50
Updated: 2021/12/16

TRC

Product number: B630205
Product name: 1-(Boc-amino)-3,3-difluorocyclobutane-1-methanol
Packaging: 25mg
Price: $60
Updated: 2021/12/16

Activate Scientific

Product number: AS57595
Product name: 1-(Boc-amino)-3,3-difluorocyclobutane-1-methanol
Purity: 97+%
Packaging: 100mg
Price: $170
Updated: 2021/12/16

Activate Scientific

Product number: AS57595
Product name: 1-(Boc-amino)-3,3-difluorocyclobutane-1-methanol
Purity: 97+%
Packaging: 250mg
Price: $361
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0419749
Product name: 1-(BOC-AMINO)-3,3-DIFLUOROCYCLOBUTANE-1-METHANOL
Purity: 95.00%
Packaging: 5MG
Price: $497.99
Updated: 2021/12/16

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tert-butyl N-[3,3-difluoro-1-(hydroxymethyl)cyclobutyl]carbamate Chemical Properties,Usage,Production

Uses

1-(Boc-amino)-3,3-difluorocyclobutane-1-methanol is used in preparation of Amide derivatives useful in the treatment of HBV infection or HBV-induced diseases.

Synthesis

1232365-41-1

1232365-42-2

The general procedure for the synthesis of tert-butyl (3,3-difluoro-1-(hydroxymethyl)cyclobutyl)carbamate from compound BB2-g (CAS: 1232365-41-1, 4 g, 0.0143 mol) was as follows: a 2 M lithium borohydride solution (30 mL) was slowly added to an anhydrous THF (100 mL) solution of compound BB2-g under ice bath cooling. The reaction mixture was then gradually warmed to room temperature. The reaction mixture was stirred continuously for 3 hours at room temperature. Upon completion of the reaction, the reaction was quenched by careful addition of ice water and 5% citric acid solution and then extracted three times with dichloromethane (DCM). The organic phases were combined, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure to afford the target product tert-butyl (3,3-difluoro-1-(hydroxymethyl)cyclobutyl)carbamate (3.1 g, 91% yield).

References

[1] Patent: WO2010/70615, 2010, A1. Location in patent: Page/Page column 28; 30
[2] Patent: WO2011/70539, 2011, A1. Location in patent: Page/Page column 24; 26
[3] Patent: WO2011/70541, 2011, A1. Location in patent: Page/Page column 25
[4] Patent: WO2011/158197, 2011, A1. Location in patent: Page/Page column 31
[5] Patent: WO2012/172473, 2012, A1. Location in patent: Page/Page column 22

tert-butyl N-[3,3-difluoro-1-(hydroxymethyl)cyclobutyl]carbamate Preparation Products And Raw materials

Raw materials

Preparation Products

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tert-butyl N-[3,3-difluoro-1-(hydroxymethyl)cyclobutyl]carbamate Suppliers

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