ChemicalBook > CAS DataBase List > TC ASK 10

TC ASK 10

Product Name
TC ASK 10
CAS No.
1005775-56-3
Chemical Name
TC ASK 10
Synonyms
TC ASK 10;ASK1 Inhibitor 10;TC ASK 10, 10 mM in DMSO;4-tert-butyl-N-(6-imidazol-1-ylimidazo[1,2-a]pyridin-2-yl)benzamide:hydrochloride;N-(6-(1H-Imidazol-1-yl)imidazo[1,2-a]pyridin-2-yl)-4-(tert-butyl)benzamide dihydrochloride;4-(1,1-Dimethylethyl)-N-[6-(1H-imidazol-1-yl)imidazo[1,2-a]pyridin-2-yl]benzamide dihydrochloride;Apoptosis,ASK1,oral,MAP3K,bioavailability,TC ASK-10,TC ASK10,Inhibitor,pharmacokinetic,JNK,TC ASK 10,p38,inhibit,selective,MAP kinase kinase kinase, MEKK, MAPKKK,Phosphorylation
CBNumber
CB13037545
Molecular Formula
C21H22ClN5O
Formula Weight
395.89
MOL File
1005775-56-3.mol
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TC ASK 10 Property

Melting point:
>270° (dec.)
storage temp. 
Refrigerator, under inert atmosphere
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
color 
White to Off-White
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
28512
Product name
ASK1 Inhibitor 10
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
28512
Product name
ASK1 Inhibitor 10
Packaging
25mg
Price
$494
Updated
2024/03/01
Cayman Chemical
Product number
28512
Product name
ASK1 Inhibitor 10
Packaging
5mg
Price
$131
Updated
2024/03/01
Cayman Chemical
Product number
28512
Product name
ASK1 Inhibitor 10
Packaging
10mg
Price
$214
Updated
2024/03/01
Tocris
Product number
4825
Product name
TCASK10
Purity
≥98%(HPLC)
Packaging
10
Price
$258
Updated
2021/12/16
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TC ASK 10 Chemical Properties,Usage,Production

Description

ASK1 inhibitor 10 is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1; IC50 = 14 nM). It is selective for ASK1 over ASK2 (IC50 = 510 nM) as well as MEKK1, TAK-1, IKKβ, ERK1, JNK1, p38α, GSK3β, PKCθ, and B-RAF (IC50s = >10,000 nM for all). It inhibits streptozotocin-induced increases in JNK and p38 phosphorylation in INS-1 pancreatic β cells in a concentration-dependent manner.

Uses

TC ASK 10 is a potent ASK1 inhibitor. It displays selectivity for ASK1 over other kinases including ASK2, MEKK1, TAK1, IKKβ, ERK1, JNK1, p38α, GSK-3β, PKCθ and B-raf. It blocks downstream JNK1/p38 phosphorylation in cells.

storage

Desiccate at RT

TC ASK 10 Preparation Products And Raw materials

Raw materials

Preparation Products

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TC ASK 10 Suppliers

China 37 United Kingdom 1 United States 9 USA 1 Global 48
ShangHai Caerulum Pharma Discovery Co., Ltd.
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1005775-56-3, TC ASK 10Related Search:


  • TC ASK 10
  • ASK1 Inhibitor 10
  • 4-tert-butyl-N-(6-imidazol-1-ylimidazo[1,2-a]pyridin-2-yl)benzamide:hydrochloride
  • 4-(1,1-Dimethylethyl)-N-[6-(1H-imidazol-1-yl)imidazo[1,2-a]pyridin-2-yl]benzamide dihydrochloride
  • Apoptosis,ASK1,oral,MAP3K,bioavailability,TC ASK-10,TC ASK10,Inhibitor,pharmacokinetic,JNK,TC ASK 10,p38,inhibit,selective,MAP kinase kinase kinase, MEKK, MAPKKK,Phosphorylation
  • N-(6-(1H-Imidazol-1-yl)imidazo[1,2-a]pyridin-2-yl)-4-(tert-butyl)benzamide dihydrochloride
  • TC ASK 10, 10 mM in DMSO
  • 1005775-56-3
  • C21H21N5O2HCl