Tenofovir alafenamide hemifumarate

ChemicalBook > CAS DataBase List > Tenofovir alafenamide hemifumarate

Tenofovir alafenamide hemifumarate

Product Name: Tenofovir alafenamide hemifumarate
CAS No.: 1392275-56-7
Chemical Name: Tenofovir alafenamide hemifumarate
Synonyms: Tenofovir Alafenamide fumarate;GS7340(Tenofovir Alafenamide Fumarate);N-[(S)-[[(1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-L-alanine 1-methylethyl ester (2E)-2-butenedioate (2:1);L-Alanine,N-[(S)-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-, 1-methylethyl ester, (2E)-2-butenedioate (2:1);Anti-HIV;API-Anti-HBV;Tenofovir Alafenamid;GS-7340 (hemifumarate);Alafenamide hemifumarate;Tenofovir levamide amine fumarate
CBNumber: CB13038481
Molecular Formula: C25H33N6O9P
Formula Weight: 592.55
MOL File: 1392275-56-7.mol

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Tenofovir alafenamide hemifumarate Property

storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: DMSO:75.0(Max Conc. mg/mL);70.16(Max Conc. mM)
CAS DataBase Reference: 1392275-56-7

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-6112
Product name: Tenofoviralafenamidehemifumarate
Purity: 99.79%
Packaging: 5mg
Price: $50
Updated: 2021/12/16

ChemScene

Product number: CS-6112
Product name: Tenofoviralafenamidehemifumarate
Purity: 99.79%
Packaging: 10mg
Price: $70
Updated: 2021/12/16

ChemScene

Product number: CS-6112
Product name: Tenofoviralafenamidehemifumarate
Purity: 99.79%
Packaging: 50mg
Price: $140
Updated: 2021/12/16

ChemScene

Product number: CS-6112
Product name: Tenofoviralafenamidehemifumarate
Purity: 99.79%
Packaging: 100mg
Price: $190
Updated: 2021/12/16

AK Scientific

Product number: V9722
Product name: Tenofoviralafenamidehemifumarate
Packaging: 5g
Price: $338
Updated: 2021/12/16

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Tenofovir alafenamide hemifumarate Chemical Properties,Usage,Production

Description

Tenofovir alafenamide hemifumarate is an investigational oral prodrug of Tenofovir. Tenofovir is a HIV-1 nucleotide reverse transcriptase inhibitor.

Chemical Properties

White to almost White crystal or crystalline powder.

Originator

Gilead Sciences

Uses

Tenofovir alafenamide hemifumarate is a newer, more effective prodrug used in combination with FTC that has recently been approved for the prevention of HIV transmission through the rectum. It is used to treat chronic hepatitis B virus (HBV) infection in adults with compensated liver disease.

Definition

ChEBI: A fumarate salt prepared from tenofovir alafenamide by reaction of one molecule of fumaric acid for every two molecules of tenofovir alafenamide. A prodrug for tenofovir, it is used in combination therapy for the treatment of HIV-1 infection.

Clinical Use

Tenofovir alafenamide hemifumarate is useful in the treatment and/or prophylaxis of one or more viral infections in man or animals, including infections caused by DNA viruses. RNA viruses, herpesviruses (e.g., CMV, HSV 1, HSV 2, VZV), retroviruses, hepadnaviruses (e.g., HBV), papillomavirus, hantavirus, adenoviruses and HIV. Like tenofovir disoproxil, tenofovir alafenamide is another prodrug form of tenofovir, and can be used in the treatment and/or prophylaxis of the same conditions.

Side effects

Check with your doctor immediately if any of the following side effects occur:
Abdominal or stomach discomfort,bloody urine,dark urine,decreased appetite,decreased frequency or amount of urine,troubled breathing,cough,headache,back pain.

Synthesis

Under a nitrogen atmosphere, 200 g of isopropanol, 9 g of fumaric acid, and 50 g of TAF-3 were sequentially added to a 2 L reaction flask. Turn on the stirring, control the temperature at 40 ~ 50 °C, stir and dissolve, filter while hot, collect the mother liquor. Transfer the mother liquor to a 2L reaction bottle, start stirring, control the temperature at 40 ~ 50 °C, stir and dissolve, slowly reduce the temperature to 0 ~ 5 ° C, cooling time 2 ~ 3 hours, heat stirring for 10 hours. Filtration, drying at 60-65 ° C for 12 to 16 hours, to obtain 37.5 g of Tenofovir Alafenamide Fumarate finished product, white powder, yield 75.0%.

Drug interactions

Some products that may interact with this drug are: adefovir, orlistat, other drugs that may harm the kidneys (including aminoglycosides such as amikacin/gentamicin).

Advantages

One major advantage of the hemifumarate form of tenofovir alafenamide over the monofumarate form is its exceptional capability to purge GS-7339 (i.e., 9-[(R)-2-[[(R)-[[(S)-1-(isopropoxycarbonyl)ethyl]amino]phenoxyphosphinyl]methoxy]propyl]adenine, which is the major diastereomeric impurity in the active pharmaceutical ingredient. Thus, the hemifumarate form of tenofovir alafenamide can be more readily and easily separated from impurities than the monofumarate form. Other major advantages of tenofovir alafenamide hemifumarate over the monofumarate form include improved thermodynamic and chemical stability (including long-term storage stability), superior process reproducibility, superior drug product content uniformity, and a higher melting point.

Tenofovir alafenamide hemifumarate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Tenofovir alafenamide hemifumarate manufacturers

Hebei Dangtong Import and export Co LTD

Product: Tenofovir alafenamide hemifumarate 1392275-56-7
Price: US $1050.00-1000.00/kilograms
Min. Order: 10kilograms
Purity: 99%
Supply Ability: 100ton
Release date: 2023-02-24

Sinoway Industrial co., ltd.

Product: Tenofovir Alafenamide Fumarate / TAF 1392275-56-7
Price: US $0.00/KG
Min. Order: 2KG
Purity: DMF, for R&D use
Supply Ability: 20 tons
Release date: 2024-04-09

Shaanxi TNJONE Pharmaceutical Co., Ltd

Product: Tenofovir Alafenamide Fumarate 1392275-56-7
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000kg
Release date: 2024-04-25

1392275-56-7, Tenofovir alafenamide hemifumarateRelated Search:

Tenofovir Alafenamide Tenofovir Diisopropyl Tenofovir FuMarate 2,4,6,8-Tetraoxa-5-phosphanonanedioic acid, 5-[[(1R)-2-[6-[[[[9-[(2R)-5-hydroxy-2,11-diMethyl-5-oxido-9-oxo-3,6,8,10-tetraoxa-5-phosphadodec-1-yl]-9H-purin-6-yl]aMino]Methyl]aMino]-9H-purin-9-yl]-1-Methylethoxy]Methyl]-, 1,9-bis(1-Methylethyl) ester, 5-ox P-[[(1S)-2-(6-AMino-9H-purin-9-yl)-1-Methylethoxy]Methyl]-phosphonic Acid Monoethyl Ester Tenofovir Alafenamide Impurity 30 Tenofovir Impurity H (E)-9-(prop-1-en-1-yl)-9H-purin-6-amine Tenofovir Related Compound 6 isopropyl ((R)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-D-alaninate TENOFOVIR-D6 Tenofovir Related Compound 1 (((((1-(6-aMino-9H-purin-9-yl)propan-2-yl)oxy)Methyl)phosphoryl)bis(oxy))bis(Methylene) isopropyl Methyl dicarbonate isopropyl ((S)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-D-alaninate Tenofovir Disopropyl Ethyl Diester Mono-POC Tenofovir FuMarate Salt ((((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(((isopropoxycarbonyl)oxy)methoxy)phosphoryl)oxy)methyl dimethylcarbamate Tenofovir disoproxil

L-Alanine,N-[(S)-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-, 1-methylethyl ester, (2E)-2-butenedioate (2:1)

N-[(S)-[[(1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-L-alanine 1-methylethyl ester (2E)-2-butenedioate (2:1)

GS-7340 (hemifumarate)

TENOFOVIR ALAFENAMIDE HEMIFUMARATE (GS-7340 HEMIFUMARATE)

Tenofovir levamide amine fumarate

GS7340(Tenofovir Alafenamide Fumarate)

(Tenofovir alafenamide : fumarate = 2:1)

Anti-HIV

API-Anti-HBV

(S)-Isopropyl 2-(((S)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)amino)propanoate fumarate(2:1)

(R)-isopropyl 2-(((S)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)amino)propanoate fumarate

N-[(S)-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-, 1-methylethyl ester

(S)-isopropyl 2-(((S)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)amino)propanoate hemifumarate

Tenofovir Alafenamide fumarate [USAN]

Alafenamide hemifumarate

Tenofovir Alafenamide Hemifumarate(2:1)

Tenofovir Alafenamide Fumarate USP/EP/BP

Tenofovir Alafenamid

Tenofovir Alafenamide Hemifumarate salt[USAN

Tenofovir alafenamide hemifumarate

Tenofovir alafenamide hemifumarate (GS-7340)

Tenofovir Alafenamide Hemifumarate salt

Tenofovir Alafenamide fumarateQ: What is Tenofovir Alafenamide fumarate Q: What is the CAS Number of Tenofovir Alafenamide fumarate

3H-1,2,4-Triazole-3-thione,4-amino-2,4-dihydro-5-(10-methoxyphenyl)-

Tenofovir Alafenamide fumarate

Isopropyl (((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-L-alaninate hemifumarate

Tenofovir dipivoxil phenol amine fumarate

2-fluoro-5-[(4' -0x0-3'H-phthalazin-1'-yl)methyllbenzoic acide'

Celiprolol Impurity 8(Celiprolol EP Impurity H)

Tenofovir Alafenamide Hemifumarate(2:1) CRS

Tenofovir Alafenamide Fumarate API

1392275-56-7

C46H62N12O14P2

2C21H29N6O5PC4H4O4

API

1392275-56-7