5-Bromo-3-chloro-2-isobutoxy-pyridine
- Product Name
- 5-Bromo-3-chloro-2-isobutoxy-pyridine
- CAS No.
- 1289093-31-7
- Chemical Name
- 5-Bromo-3-chloro-2-isobutoxy-pyridine
- Synonyms
- 5-Bromo-3-chloro-2-isobutoxy-pyridine;5-Bromo-3-chloro-2-(2-methylpropoxy)pyridine;Pyridine, 5-bromo-3-chloro-2-(2-methylpropoxy)
- CBNumber
- CB13039620
- Molecular Formula
- C9H11BrClNO
- Formula Weight
- 264.55
- MOL File
- 1289093-31-7.mol
5-Bromo-3-chloro-2-isobutoxy-pyridine Property
- Boiling point:
- 267.5±35.0 °C(Predicted)
- Density
- 1.432±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- -0.76±0.32(Predicted)
- Appearance
- Colorless to light yellow Liquid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 182235
- Product name
- 5-Bromo-3-chloro-2-isobutoxypyridine
- Purity
- 95%
- Packaging
- 5g
- Price
- $908
- Updated
- 2021/12/16
- Product number
- 3126AJ
- Product name
- 5-Bromo-3-chloro-2-(2-methylpropoxy)pyridine
- Packaging
- 5g
- Price
- $928
- Updated
- 2021/12/16
- Product number
- 69R0913
- Product name
- 5-Bromo-3-chloro-2-isobutoxy-pyridine
- Purity
- 97%
- Packaging
- 5g
- Price
- $2554
- Updated
- 2021/12/16
- Product number
- A108059
- Product name
- 5-Bromo-3-chloro-2-isobutoxypyridine
- Purity
- 97%
- Packaging
- 250mg
- Price
- $16
- Updated
- 2021/12/16
- Product number
- A108059
- Product name
- 5-Bromo-3-chloro-2-isobutoxypyridine
- Purity
- 97%
- Packaging
- 1g
- Price
- $43
- Updated
- 2021/12/16
5-Bromo-3-chloro-2-isobutoxy-pyridine Chemical Properties,Usage,Production
Synthesis
38185-56-7
78-83-1
1289093-31-7
Step-1: Synthesis of 5-bromo-3-chloro-2-isobutoxypyridine To a solution of 5-bromo-3-chloro-2-fluoropyridine (5.0 g, 23.7 mmol) and 2-methylpropan-1-ol (5.28 g, 71.3 mmol) in DMSO (100 mL) was added CS2CO3 (23.0 g, 71.3 mmol). The reaction mixture was heated at 90 °C for 3 hours. After the reaction was completed, the mixture was cooled to room temperature and diluted by adding water (500 mL). The aqueous layer was extracted with ether (2 x 500 mL). The organic extracts were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to give the crude product. The crude product was purified by column chromatography (silica gel 100-200 mesh, 0-5% ethyl acetate in hexane solution) to afford the target compound 5-bromo-3-chloro-2-isobutoxypyridine (5.0 g, 86% yield) as a colorless oil. TLC conditions: 10% hexane solution of ethyl acetate, product Rf value: 0.8. MS (ESI, cation mode): no ionization peaks were observed. 1H NMR (400MHz, CDCl3) δ 8.06 (d, J = 2.2Hz, 1H), 7.74 (d, J = 2.2Hz, 1H), 4.11 (d, J = 6.7Hz, 2H), 2.12 (dp, J = 13.4,6.7Hz, 1H), 1.03 (d, J = 6.7Hz, 6H).
References
[1] Patent: WO2015/51043, 2015, A1. Location in patent: Paragraph 00214
[2] Journal of Medicinal Chemistry, 2016, vol. 59, # 17, p. 7818 - 7839
[3] Patent: WO2018/127800, 2018, A1. Location in patent: Page/Page column 156
[4] Patent: WO2017/184658, 2017, A1. Location in patent: Page/Page column 24
[5] Patent: WO2012/95781, 2012, A1. Location in patent: Page/Page column 103-104
5-Bromo-3-chloro-2-isobutoxy-pyridine Preparation Products And Raw materials
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