MK2-IN-1 (hydrochloride)
- Product Name
- MK2-IN-1 (hydrochloride)
- CAS No.
- 1314118-94-9
- Chemical Name
- MK2-IN-1 (hydrochloride)
- Synonyms
- MK 25;MK2 Inhibitor IV;MK 25 (hydrochloride);MK2-IN-1 (hydrochloride);MK2 inhibitor 1 hydrochloride;5-(4-Chlorophenyl)-N-(4-(piperazin-1-yl)phenyl)-N-(pyridin-2-ylmethyl)furan-2-carboxamide hydrochloride;5-(4-Chlorophenyl)-N-(4-(piperazin-1-yl)phenyl)-N-(pyridin-2-ylmethyl)furan-2-carboxamide hydrochloride[MK2 Inhibitor Hydrochloride];inhibit,MAP kinase activated protein kinase 2,MAPK activated protein kinase 2,MAPKAPK2 (MK2),Inhibitor,MK2IN1 hydrochloride,MK2 IN 1 hydrochloride,MAPKAP kinase 2,MK-2-IN-1 hydrochloride,Mitogen-activated protein kinase activated protein kinase 2
- CBNumber
- CB13041430
- Molecular Formula
- C27H26Cl2N4O2
- Formula Weight
- 509.43
- MOL File
- 1314118-94-9.mol
MK2-IN-1 (hydrochloride) Property
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- insoluble in DMSO; ≥16.5 mg/mL in EtOH with ultrasonic; ≥37.4 mg/mL in H2O
- form
- A crystalline solid
- color
- Light yellow to pink
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 14399
- Product name
- MK2 Inhibitor IV
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $81
- Updated
- 2024/03/01
- Product number
- 14399
- Product name
- MK2 Inhibitor IV
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $152
- Updated
- 2024/03/01
- Product number
- 14399
- Product name
- MK2 Inhibitor IV
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $356
- Updated
- 2024/03/01
- Product number
- 1740DU
- Product name
- MK2-IN-1hydrochloride
- Packaging
- 50mg
- Price
- $417
- Updated
- 2021/12/16
- Product number
- CS-4584
- Product name
- MK2-IN-1hydrochloride
- Purity
- 99.19%
- Packaging
- 50mg
- Price
- $480
- Updated
- 2021/12/16
MK2-IN-1 (hydrochloride) Chemical Properties,Usage,Production
Biological Activity
mk2 inhibitor iv is a highly selective and non-atp competitive mk2 inhibitor with ic50 value of 0.11 μm [1].map kinase-activated protein kinase 2 (mapkapk2 or mk2) is a member of the ser/thr protein kinase family and regulated through direct phosphorylation by p38 map kinase. activation of the p38/mk2 pathway involved in promoting pro-inflammatory cytokine production and related inflammatory diseases [1].mk2 inhibitor iv is a highly selective and non-atp competitive mk2 inhibitor. in a broad panel of 150 protein kinases, mk2 inhibitor iv only significantly inhibited ck1γ3 at greater than 50%. mk2 inhibitor iv also demonstrated no inhibition against a panel of cytochrome p450 (cyp) enzymes up to 30 μm. in the human thp1 acute monocytic leukemia cell line, mk2 inhibitor iv inhibited pro-inflammatory cytokine secretion. mk2 inhibitor iv also dose-dependently inhibited lps-stimulated tnfα and il6 secretion with ic50 values of 4.4 μm and 5.2 μm, respectively. in the sw1353 chondrosarcoma cell line and human primary chondrocyte cultures, mk2 inhibitor iv dose dependently inhibited il1β-stimulated matrixmetalloprotease (mmp)13 secretion with ic50 values of 5.7 μm and 2.2 μm, respectively.
References
[1]. huang x, shipps gw jr, cheng cc, et al. discovery and hit-to-lead optimization of non-atp competitive mk2 (mapkapk2) inhibitors. acs med chem lett. 2011 jun 24;2(8):632-7.
MK2-IN-1 (hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
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