ChemicalBook > CAS DataBase List > MK2-IN-1 (hydrochloride)

MK2-IN-1 (hydrochloride)

Product Name
MK2-IN-1 (hydrochloride)
CAS No.
1314118-94-9
Chemical Name
MK2-IN-1 (hydrochloride)
Synonyms
MK 25;MK2 Inhibitor IV;MK 25 (hydrochloride);MK2-IN-1 (hydrochloride);MK2 inhibitor 1 hydrochloride;5-(4-Chlorophenyl)-N-(4-(piperazin-1-yl)phenyl)-N-(pyridin-2-ylmethyl)furan-2-carboxamide hydrochloride;5-(4-Chlorophenyl)-N-(4-(piperazin-1-yl)phenyl)-N-(pyridin-2-ylmethyl)furan-2-carboxamide hydrochloride[MK2 Inhibitor Hydrochloride];inhibit,MAP kinase activated protein kinase 2,MAPK activated protein kinase 2,MAPKAPK2 (MK2),Inhibitor,MK2IN1 hydrochloride,MK2 IN 1 hydrochloride,MAPKAP kinase 2,MK-2-IN-1 hydrochloride,Mitogen-activated protein kinase activated protein kinase 2
CBNumber
CB13041430
Molecular Formula
C27H26Cl2N4O2
Formula Weight
509.43
MOL File
1314118-94-9.mol
More
Less

MK2-IN-1 (hydrochloride) Property

storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
insoluble in DMSO; ≥16.5 mg/mL in EtOH with ultrasonic; ≥37.4 mg/mL in H2O
form 
A crystalline solid
color 
Light yellow to pink
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
14399
Product name
MK2 Inhibitor IV
Purity
≥95%
Packaging
5mg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
14399
Product name
MK2 Inhibitor IV
Purity
≥95%
Packaging
10mg
Price
$152
Updated
2024/03/01
Cayman Chemical
Product number
14399
Product name
MK2 Inhibitor IV
Purity
≥95%
Packaging
25mg
Price
$356
Updated
2024/03/01
AK Scientific
Product number
1740DU
Product name
MK2-IN-1hydrochloride
Packaging
50mg
Price
$417
Updated
2021/12/16
ChemScene
Product number
CS-4584
Product name
MK2-IN-1hydrochloride
Purity
99.19%
Packaging
50mg
Price
$480
Updated
2021/12/16
More
Less

MK2-IN-1 (hydrochloride) Chemical Properties,Usage,Production

Biological Activity

mk2 inhibitor iv is a highly selective and non-atp competitive mk2 inhibitor with ic50 value of 0.11 μm [1].map kinase-activated protein kinase 2 (mapkapk2 or mk2) is a member of the ser/thr protein kinase family and regulated through direct phosphorylation by p38 map kinase. activation of the p38/mk2 pathway involved in promoting pro-inflammatory cytokine production and related inflammatory diseases [1].mk2 inhibitor iv is a highly selective and non-atp competitive mk2 inhibitor. in a broad panel of 150 protein kinases, mk2 inhibitor iv only significantly inhibited ck1γ3 at greater than 50%. mk2 inhibitor iv also demonstrated no inhibition against a panel of cytochrome p450 (cyp) enzymes up to 30 μm. in the human thp1 acute monocytic leukemia cell line, mk2 inhibitor iv inhibited pro-inflammatory cytokine secretion. mk2 inhibitor iv also dose-dependently inhibited lps-stimulated tnfα and il6 secretion with ic50 values of 4.4 μm and 5.2 μm, respectively. in the sw1353 chondrosarcoma cell line and human primary chondrocyte cultures, mk2 inhibitor iv dose dependently inhibited il1β-stimulated matrixmetalloprotease (mmp)13 secretion with ic50 values of 5.7 μm and 2.2 μm, respectively.

References

[1]. huang x, shipps gw jr, cheng cc, et al. discovery and hit-to-lead optimization of non-atp competitive mk2 (mapkapk2) inhibitors. acs med chem lett. 2011 jun 24;2(8):632-7.

MK2-IN-1 (hydrochloride) Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

MK2-IN-1 (hydrochloride) Suppliers

Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
Guangzhou QiYun Biotechnology Co., Ltd.
Tel
020-61288194 61288195
Fax
020-61288700
Email
505721671@qq.com
Country
China
ProdList
3866
Advantage
58
Shanghai SuperLan Chemcial Technique Centre
Tel
021-2022843681 15618226720
Fax
+86-21-51601218
Email
lucy@atkchemical.com
Country
China
ProdList
10285
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
MQ (shanghai) Pharmaceuticals Co., Ltd.
Tel
13761635123
Fax
1014988033@qq
Email
1014988033@qq.com
Country
China
ProdList
4983
Advantage
55
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
Angel Pharmatech, Ltd.
Tel
17317130613
Fax
QQ3358272972
Email
3358272972@qq.com
Country
China
ProdList
3251
Advantage
58
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9729
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32165
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58

1314118-94-9, MK2-IN-1 (hydrochloride)Related Search:


  • MK2-IN-1 (hydrochloride)
  • MK2 Inhibitor IV
  • MK 25 (hydrochloride)
  • MK2 inhibitor 1 hydrochloride
  • MK 25
  • 5-(4-Chlorophenyl)-N-(4-(piperazin-1-yl)phenyl)-N-(pyridin-2-ylmethyl)furan-2-carboxamide hydrochloride[MK2 Inhibitor Hydrochloride]
  • 5-(4-Chlorophenyl)-N-(4-(piperazin-1-yl)phenyl)-N-(pyridin-2-ylmethyl)furan-2-carboxamide hydrochloride
  • inhibit,MAP kinase activated protein kinase 2,MAPK activated protein kinase 2,MAPKAPK2 (MK2),Inhibitor,MK2IN1 hydrochloride,MK2 IN 1 hydrochloride,MAPKAP kinase 2,MK-2-IN-1 hydrochloride,Mitogen-activated protein kinase activated protein kinase 2
  • 1314118-94-9
  • C27H25ClN4O2HCl