VR23
- Product Name
- VR23
- CAS No.
- 1624602-30-7
- Chemical Name
- VR23
- Synonyms
- VR23;CS-1579;VR23(VR-23);VR23 >=98% (HPLC);7-chloro-4-(4-((2,4-dinitrophenyl)sulfonyl)piperazin-1-yl)quinoline;7-Chloro-4-[4-[(2,4-dinitrophenyl)sulfonyl]-1-piperazinyl]quinoline;Quinoline, 7-chloro-4-[4-[(2,4-dinitrophenyl)sulfonyl]-1-piperazinyl]-
- CBNumber
- CB13049249
- Molecular Formula
- C19H16ClN5O6S
- Formula Weight
- 477.88
- MOL File
- 1624602-30-7.mol
VR23 Property
- storage temp.
- Store at -20°C
- solubility
- insoluble in EtOH; insoluble in H2O; ≥45.55 mg/mL in DMSO
- form
- Powder
- color
- Light yellow to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 19133
- Product name
- VR23
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $36
- Updated
- 2024/03/01
- Product number
- 19133
- Product name
- VR23
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $155
- Updated
- 2024/03/01
- Product number
- 19133
- Product name
- VR23
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $274
- Updated
- 2024/03/01
- Product number
- 19133
- Product name
- VR23
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $553
- Updated
- 2024/03/01
- Product number
- V767023
- Product name
- VR23
- Packaging
- 100mg
- Price
- $440
- Updated
- 2021/12/16
VR23 Chemical Properties,Usage,Production
Description
VR23 is a chloroquine derivative that functions as a proteasome inhibitor (IC50s = 1 nM, 50-100 nM, and 3 μM for trypsin-like, chymotrypsin-like, and caspase-like proteasomes, respectively). It also deregulates the activity of cyclin E and other centrosomal proteins, resulting in the induction of multiple centrosome amplification, abnormal spindle formation, uneven cytokinesis, irreversible mitotic arrest, and eventually apoptosis that is specific to cancer cells. In combination with the chymotrypsin-like proteasome inhibitor bortezomib , VR23 can produce a synergistic effect in killing multiple myeloma cells, including those that are resistant to bortezomib.
Uses
VR23 is a quinoline-sulfonyl hybrid proteasome inhibitor which is used in cancer therapeutics. Targets cancer via cycline E-mediated centrosome.
in vivo
vr23 was effective in controlling metastatic breast cancer cells and multiple myelomas [1]. in engrafted animals, the treatment with vr23 at 30 mg/kg twice per week for three weeks inhibited tumor growth effectively. following 24 hours pre-treatment with paclitaxel at 20mg/kg/week, the administration of vr23 enhanced the anti-tumor activity of paclitaxel by 70%. histological data showed that vr23 substantially decreased mitotic index, inhibited tumor infiltration into surrounding tissues and remarkably reduced tumor cell proliferation and angiogenesis [4].
References
[1]. pundir s, vu hy, solomon vr, et al. vr23: a quinoline-sulfonyl hybrid proteasome inhibitor that selectively kills cancer via cyclin e-mediated centrosome amplification. cancer research, 2015, 75(19): 4164-4175.
[2]. almond jb, cohen gm. the proteasome: a novel target for cancer chemotherapy. leukemia, 2002, 16(4): 433-443.
[3]. adams j, palombella vj, sausville ea, et al. proteasome inhibitors: a novel class of potent and effective antitumor agents. cancer research, 1999, 59(11): 2615-2622.
[4]. vu hyt, pundir s, solomon rv, et al. anticancer effects and mechanism of vr23, a novel chloroquine derivative. cancer research, 2014, 74(19 supplement): 4545-4545.
VR23 Preparation Products And Raw materials
Raw materials
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