FIIN-2

ChemicalBook > CAS DataBase List > FIIN-2

Product Name: FIIN-2
CAS No.: 1633044-56-0
Chemical Name: FIIN-2
Synonyms: FIN-2;FIIN-2;CS-1618;FIIN2;FIIN-2;FIIN 2;inhibit,FGFR,FIIN2,FIIN 2,Fibroblast growth factor receptor,Inhibitor,FIIN-2;N-[4-[[3-(3,5-Dimethoxyphenyl)-3,4-dihydro-7-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-oxopyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl]phenyl]-2-propenamide;2-Propenamide, N-[4-[[3-(3,5-dimethoxyphenyl)-3,4-dihydro-7-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-oxopyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl]phenyl]-
CBNumber: CB13049254
Molecular Formula: C35H38N8O4
Formula Weight: 634.73
MOL File: 1633044-56-0.mol

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FIIN-2 Property

Density: 1.306±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≥31.75 mg/mL in DMSO; insoluble in H2O; ≥3.39 mg/mL in EtOH with gentle warming
form: solid
pka: 13.51±0.70(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19837
Product name: FIIN-2
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 19837
Product name: FIIN-2
Purity: ≥98%
Packaging: 5mg
Price: $151
Updated: 2024/03/01

Cayman Chemical

Product number: 19837
Product name: FIIN-2
Purity: ≥98%
Packaging: 10mg
Price: $278
Updated: 2024/03/01

Cayman Chemical

Product number: 19837
Product name: FIIN-2
Purity: ≥98%
Packaging: 25mg
Price: $533
Updated: 2024/03/01

TRC

Product number: F336505
Product name: FIIN2
Packaging: 5mg
Price: $275
Updated: 2021/12/16

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FIIN-2 Chemical Properties,Usage,Production

Description

FIIN-2 is an irreversible FGFR inhibitor with IC₅₀ values of 3.09, 4.3, 27, and 45.3 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively. It has been shown to inhibit cell proliferation of transformed Ba/F3 cell lines and demonstrates antiproliferative activity in cells dependent upon the gatekeeper mutants of FGFR1 or FGFR2. By inhibiting FGFR in a zebrafish developmental model, FIIN-2 caused mild to severe alterations in tail morphogenesis similar to the phenotypes reported following genetic knockdown of FGFR.

Uses

FIIN 2 is FGFR inhibitor. It can be used in biological study of DFG-out mode of inhibition by an irreversible Type-1 inhibitor capable of overcoming gate-keeper mutations in FGF receptors

FIIN-2 Preparation Products And Raw materials

Raw materials

Preparation Products

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1633044-56-0, FIIN-2Related Search:

CS-1618

FIIN2;FIIN-2;FIIN 2

FIIN-2

FIN-2

N-[4-[[3-(3,5-Dimethoxyphenyl)-3,4-dihydro-7-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-oxopyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl]phenyl]-2-propenamide

2-Propenamide, N-[4-[[3-(3,5-dimethoxyphenyl)-3,4-dihydro-7-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-oxopyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl]phenyl]-

inhibit,FGFR,FIIN2,FIIN 2,Fibroblast growth factor receptor,Inhibitor,FIIN-2

1633044-56-0

1533044-56-0

C35H38N8O4