ChemicalBook > CAS DataBase List > 3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile

3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile

Product Name
3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile
CAS No.
913830-15-6
Chemical Name
3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile
Synonyms
NS 9283;NS-9283;NS9283;NS 9283;NS-9283;NS9283;3-[3-(3-Pyridinyl)-1,2,4-oxadiazol-5-yl]benzonitrile;3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile;Benzonitrile, 3-[3-(3-pyridinyl)-1,2,4-oxadiazol-5-yl]-;NS9283,Inhibitor,Nicotinic acetylcholine receptors,nAChR,inhibit
CBNumber
CB13049683
Molecular Formula
C14H8N4O
Formula Weight
248.24
MOL File
913830-15-6.mol
More
Less

3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile Property

Boiling point:
469.9±55.0 °C(Predicted)
Density 
1.37±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 10 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml; DMSO: 3 mg/ml; Ethanol: Partially soluble
form 
A crystalline solid
pka
1.40±0.12(Predicted)
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
29189
Product name
NS 9283
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
29189
Product name
NS 9283
Packaging
25mg
Price
$420
Updated
2024/03/01
Cayman Chemical
Product number
29189
Product name
NS 9283
Packaging
5mg
Price
$122
Updated
2024/03/01
Cayman Chemical
Product number
29189
Product name
NS 9283
Packaging
10mg
Price
$184
Updated
2024/03/01
Tocris
Product number
5112
Product name
NS9283
Purity
≥99%(HPLC)
Packaging
10
Price
$201
Updated
2021/12/16
More
Less

3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile Chemical Properties,Usage,Production

Description

NS 9283 is a positive allosteric modulator of α4β2 subunit-containing nicotinic acetylcholine receptors (nAChRs) that potentiates ACh-induced currents in HEK293 cells expressing human α4β2 subunit-containing nAChRs (EC50 = 4 μM). In vivo, NS 9283 potentiates ABT-594 analgesic efficacy in rat models of carrageenan-induced thermal hyperalgesia, paw skin incision post-operative pain, and monoiodoacetate-induced osteoarthritis. It reduces nicotine, but not sucrose, self-administration and reinstatement in rats when administered at a dose of 3.5 mg/kg.

Uses

NS 9283 is a positive allosteric modulator of α4β2 receptor affecting the potency of acetylcholine (Ach) related events. This has been linked to affect on everyday brain function including cognitive function and pain alleviation.

storage

Store at +4°C

3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile Suppliers

China 32 United Kingdom 1 United States 4 USA 1 Global 38
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2923
Advantage
55
Shanghai JiYi Biotechnology Co. Ltd.
Tel
13621943973
Fax
-
Email
sales@shjiyipharmatech.com
Country
China
ProdList
1166
Advantage
55
D&C Chemicals
Tel
+86-21-58447131
Fax
+86-21-61642470
Email
1724405207@qq.com
Country
China
ProdList
472
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9708
Advantage
58
Shanghai Biopharmaleader Co., Ltd.
Tel
+86 18721201413
Fax
+86 (21) 5775-8967
Email
sales@biopharmaleader.com
Country
China
ProdList
1720
Advantage
58
Angel Pharmatech, Ltd.
Tel
17317130613
Fax
QQ3358272972
Email
3358272972@qq.com
Country
China
ProdList
3246
Advantage
58
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6870
Advantage
58
DC Chemicals
Tel
021-58447131 13564518121
Email
sales@dcchemicals.com
Country
China
ProdList
9412
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11289
Advantage
58
Absin Bioscience Inc.
Tel
021-38015121 15000105423
Email
chenjw@absin.cn
Country
China
ProdList
24734
Advantage
58
Hebei Weite Medical Technology Co., Ltd
Tel
13180081292
Email
contact@wetogethermed.com
Country
China
ProdList
7321
Advantage
58
Nantong Hi-Future Biotechnology Co., Ltd
Tel
18051384581
Email
sales@chemhifuture.com
Country
China
ProdList
3061
Advantage
58
Hefei Ruiluo New Material Technology Co., Ltd.
Tel
19567218739
Email
1759672789@qq.com
Country
China
ProdList
1484
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24017
Advantage
58
Shanghai Tachizaki Biomedical Research Center
Tel
18014399201
Email
sales@chemlab-tachizaki.com
Country
China
ProdList
2494
Advantage
58
Nanjing Shizhou Biology Technology Co.,Ltd
Tel
025-85560043 15850508050
Fax
025-85563444
Email
cindy.huang@synzest.com
Country
China
ProdList
12007
Advantage
58
Shanghai Aladdin Biochemical Technology Co.,Ltd.
Tel
+86-18521732826
Email
market@aladdin-e.com
Country
China
ProdList
48467
Advantage
58
RD International Technology Co., Limited
Tel
18024082417
Email
market@ubiochem.com
Country
China
ProdList
9180
Advantage
58
ShenZhen Trendseen Biological Technology Co.,Ltd.
Tel
13417589054
Email
trendseenbio@gmail.com
Country
China
ProdList
11681
Advantage
58
Wuhan Topule Biopharmaceutical Co., Ltd
Tel
+8618327326525
Email
masar@topule.com
Country
China
ProdList
8474
Advantage
58
Nantong HI-FUTURE Biology Co., Ltd.
Tel
+undefined18051384581
Email
sales@chemhifuture.com
Country
China
ProdList
3136
Advantage
58
Xiamen Research Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
1562893815@qq.com
Country
CHINA
ProdList
6942
Advantage
58
Shanghai Hao Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
shxiyuanbio@163.com
Country
CHINA
ProdList
6921
Advantage
58
Beijing Shengke Boyuan Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
978560024@qq.com
Country
CHINA
ProdList
6011
Advantage
58
Shanghai Yuqi Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
847627550@qq.com
Country
CHINA
ProdList
6087
Advantage
58
Shanghai Haoyang Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
596799915@QQ.COM
Country
CHINA
ProdList
2905
Advantage
58
Beijing Bolide Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
1985563437@qq.com
Country
CHINA
ProdList
6172
Advantage
58
Shanghai Yubo Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
344843571@qq.com
Country
CHINA
ProdList
6322
Advantage
58
Wuhan Boot Biotechnology Co., Ltd.
Tel
--
Fax
--
Country
CHINA
ProdList
6829
Advantage
58
Shanghai Hao Zhun Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
info@zzsrm.com
Country
CHINA
ProdList
6846
Advantage
58
Absin Bioscience Inc.
Tel
--
Fax
--
Email
chenjw@absin.cn
Country
CHINA
ProdList
6661
Advantage
58

913830-15-6, 3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrileRelated Search:


  • 3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile
  • NS 9283
  • 3-[3-(3-Pyridinyl)-1,2,4-oxadiazol-5-yl]benzonitrile
  • NS 9283;NS-9283;NS9283
  • NS-9283;NS9283
  • Benzonitrile, 3-[3-(3-pyridinyl)-1,2,4-oxadiazol-5-yl]-
  • NS9283,Inhibitor,Nicotinic acetylcholine receptors,nAChR,inhibit
  • 913830-15-6