Naloxegol Oxalate

ChemicalBook > CAS DataBase List > Naloxegol Oxalate

Product Name: Naloxegol Oxalate
CAS No.: 1354744-91-4
Chemical Name: Naloxegol Oxalate
Synonyms: NKTR-118;NKTR 118 oxalate;Naloxegol Oxalate;AZ 13337019 oxalate;Naloxegol oxalate salt;NKTR-118;NKTR118;NKTR 118;Naloxegol Oxalate NKTR-118;(5alpha,6alpha)-4,5-Epoxy-6-(3,6,9,12,15,18,21-heptaoxadocos-1-yloxy)-17-(2-propen-1-yl)-morphinan-3,14-diol ethanedioate;Morphinan-3,14-diol,4,5-epoxy-6-(3,6,9,12,15,18,21-heptaoxadocos-1-yloxy)-17-(2-propen-1-yl)-,(5α,6α)-,ethanedioate(1:1)(salt);Naloxegol OxalateQ: What is Naloxegol Oxalate Q: What is the CAS Number of Naloxegol Oxalate Q: What is the storage condition of Naloxegol Oxalate
CBNumber: CB13049698
Molecular Formula: C36H55NO15
Formula Weight: 741.83
MOL File: 1354744-91-4.mol

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Naloxegol Oxalate Property

Melting point:: 92-95°C
storage temp.: -20°C Freezer, Under inert atmosphere
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
color: White to Off-White

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H318Causes serious eye damage

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H335May cause respiratory irritation

H341Suspected of causing genetic defects

H361Suspected of damaging fertility or the unborn child

H370Causes damage to organs

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P272Contaminated work clothing should not be allowed out of the workplace.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P284Wear respiratory protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P341IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P310Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

P363Wash contaminated clothing before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 23731
Product name: Naloxegol (oxalate)
Purity: ≥98%
Packaging: 5mg
Price: $178
Updated: 2024/03/01

Cayman Chemical

Product number: 23731
Product name: Naloxegol (oxalate)
Purity: ≥98%
Packaging: 10mg
Price: $319
Updated: 2024/03/01

Cayman Chemical

Product number: 23731
Product name: Naloxegol (oxalate)
Purity: ≥98%
Packaging: 25mg
Price: $573
Updated: 2024/03/01

Cayman Chemical

Product number: 23731
Product name: Naloxegol (oxalate)
Purity: ≥98%
Packaging: 50mg
Price: $935
Updated: 2024/03/01

TRC

Product number: N284475
Product name: NaloxegolOxalate
Packaging: 25mg
Price: $475
Updated: 2021/12/16

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Naloxegol Oxalate Chemical Properties,Usage,Production

Description

Naloxegol oxalate (XXI) is a peripherally acting μ-opioid receptor antagonist that was approved in the USA and EU for the treatment of opioid-induced constipation in adults with chronic non-cancer pain. The drug, a pegylated version of naloxone, has significantly reduced central nervous system (CNS) penetration and works by inhibiting the binding of opioids in the gastrointestinal tract. Naloxegol oxalate was developed by Nektar and licensed to AstraZeneca. Although we were unable to find a single report in the primary or patent literature that describes the exact experimental procedures to prepare naloxegol oxalate, there have been reports on the preparation of closely related analogs with specific reports on improving the selectivity of the reduction step156 and the salt formation of the final drug substance.

Uses

Naloxegol Oxalate is an oxalate form of Naloxegol (N284470) which is a peripherally-selective opioid antagonist.

Synthesis

Naloxone (180) was treated with methoxyethyl chloride in the presence of Hunig?ˉs base to give the protected ketone 181. Reduction of the ketone with potassium trisec- butylborohydride exclusively provided the a-alcohol 182 in 85% yield. Alternatively, sodium trialkylborohydrides could also be used to provide similar a-selective reduction in high yield. Deprotonation of the alcohol with sodium hydride followed by alkylation with CH3(OCH2CH2)7Br (183) provided the pegylated intermediate 184 in 88% yield. Acidic removal of the methoxyethyl ether protecting group followed by treatment with oxalic acid and crystallization provided naloxegol oxalate (XXI) in good yield.

Naloxegol Oxalate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Naloxegol Oxalate manufacturers

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Product: Naloxegol Oxalate 1354744-91-4
Price: US $0.00/g
Min. Order: 1g
Purity: More Than 99%
Supply Ability: 100kg/Month
Release date: 2024-09-14

Hebei Weibang Biotechnology Co., Ltd

Product: Naloxegol Oxalate 1354744-91-4
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-29

Hebei Mojin Biotechnology Co., Ltd

Product: Naloxegol Oxalate 1354744-91-4
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-09-27

1354744-91-4, Naloxegol OxalateRelated Search:

Naloxegol Oxalate

Naloxegol Oxalate NKTR-118

NKTR-118

NKTR-118;NKTR118;NKTR 118

(5alpha,6alpha)-4,5-Epoxy-6-(3,6,9,12,15,18,21-heptaoxadocos-1-yloxy)-17-(2-propen-1-yl)-morphinan-3,14-diol ethanedioate

AZ 13337019 oxalate

NKTR 118 oxalate

(4R,4aS,7S,7aR,12bS)-7-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]-3-prop-2-enyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,9-diol,oxalic acid

(4R,4aS,7S,7aR,12bS)-7-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]-3-prop-2-enyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,9-diol

Morphinan-3,14-diol,4,5-epoxy-6-(3,6,9,12,15,18,21-heptaoxadocos-1-yloxy)-17-(2-propen-1-yl)-,(5α,6α)-,ethanedioate(1:1)(salt)

Naloxegol oxalate salt

Naloxegol OxalateQ: What is Naloxegol Oxalate Q: What is the CAS Number of Naloxegol Oxalate Q: What is the storage condition of Naloxegol Oxalate

1354744-91-4

C34H53NO11C2H2O4