6-Bromo-8-fluoro-3,4-dihydroisoquinolin-1(2H)-one
- Product Name
- 6-Bromo-8-fluoro-3,4-dihydroisoquinolin-1(2H)-one
- CAS No.
- 1242157-15-8
- Chemical Name
- 6-Bromo-8-fluoro-3,4-dihydroisoquinolin-1(2H)-one
- Synonyms
- 6-Bromo-8-fluoro-3,4-dihydro-2H-isoquinolin-1-one;6-Bromo-8-fluoro-3,4-dihydroisoquinolin-1(2H)-one;1(2H)-Isoquinolinone, 6-bromo-8-fluoro-3,4-dihydro-;6-bromo-8-fluoro-1,2,3,4-tetrahydroisoquinolin-1-one;6-bromo-8-fluoro-3,4-dihydro-2H-isoquinolin-1-one - [B81907]
- CBNumber
- CB13051413
- Molecular Formula
- C9H7BrFNO
- Formula Weight
- 244.06
- MOL File
- 1242157-15-8.mol
6-Bromo-8-fluoro-3,4-dihydroisoquinolin-1(2H)-one Property
- Boiling point:
- 460.1±45.0 °C(Predicted)
- Density
- 1.635±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 13.24±0.20(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C9H7BrFNO/c10-6-3-5-1-2-12-9(13)8(5)7(11)4-6/h3-4H,1-2H2,(H,12,13)
- InChIKey
- QNEGTSCEMNYFFK-UHFFFAOYSA-N
- SMILES
- C1(=O)C2=C(C=C(Br)C=C2F)CCN1
Safety
- HS Code
- 2933499090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- AS146501
- Product name
- 6-Bromo-8-fluoro-3,4-dihydroisoquinolin-1(2H)-one
- Purity
- 95%
- Packaging
- 100mg
- Price
- $301
- Updated
- 2021/12/16
- Product number
- PC421086
- Product name
- 6-Bromo-8-fluoro-3,4-dihydroisoquinolin-1(2h)-one
- Purity
- 95%
- Packaging
- 250mg
- Price
- $725
- Updated
- 2021/12/16
- Product number
- 4826DP
- Product name
- 6-Bromo-8-fluoro-3,4-dihydroisoquinolin-1(2H)-one
- Packaging
- 1g
- Price
- $1010
- Updated
- 2021/12/16
- Product number
- A247800
- Product name
- 6-Bromo-8-fluoro-3,4-dihydroisoquinolin-1(2H)-one
- Purity
- 95+%
- Packaging
- 100mg
- Price
- $214
- Updated
- 2021/12/16
- Product number
- 1242157158
- Product name
- 6-Bromo-8-fluoro-3,4-dihydroisoquinolin-1(2H)-one
- Packaging
- 250mg
- Price
- $523.2
- Updated
- 2021/12/16
6-Bromo-8-fluoro-3,4-dihydroisoquinolin-1(2H)-one Chemical Properties,Usage,Production
Synthesis
1242157-14-7
1242157-15-8
Step 4: To a solution of dichloromethane (DCM, 75 mL) containing 5-bromo-7-fluoro-1-indanone (144d, 10.35 g, 45.19 mmol) was slowly added methanesulfonic acid (52.73 mL, 70.92 g, 737.90 mmol), followed by batchwise addition of sodium azide (5.88 g, 90.44 mmol), at 0 °C. The reaction mixture was stirred continuously at 0 °C for 2 hours. Upon completion of the reaction, the reaction was quenched by the addition of 20% aqueous sodium hydroxide solution (40 mL) and stirring was continued for 30 min. The aqueous phase was extracted with dichloromethane (DCM, 400 mL x 3) and the organic layers were combined. The organic layer was washed sequentially with saturated brine (200 mL × 2), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate=10/1 to 2/1) to afford 6-bromo-8-fluoro-3,4-dihydroisoquinolin-1(2H)-one (144e, 5.2 g, 47.1% yield). The product was confirmed by 1H NMR (400 MHz, CDCl3): δ 7.22-7.25 (d, J=10.4 Hz, 1H), 7.20 (s, 1H), 6.94 (s, 1H), 3.46-3.53 (m, 2H), 2.88-2.97 (m, 2H); MS-ESI [M+H]+=243.9/245.9.
References
[1] Patent: WO2015/949, 2015, A1. Location in patent: Page/Page column 106-107
[2] Patent: US2010/222325, 2010, A1. Location in patent: Page/Page column 140-141
[3] Journal of Medicinal Chemistry, 2015, vol. 58, # 1, p. 512 - 516
6-Bromo-8-fluoro-3,4-dihydroisoquinolin-1(2H)-one Preparation Products And Raw materials
Raw materials
Preparation Products
6-Bromo-8-fluoro-3,4-dihydroisoquinolin-1(2H)-one Suppliers
- Tel
- 15601952568
- Fax
- 3004479441
- sales4@myuchem.com
- Country
- China
- ProdList
- 2983
- Advantage
- 58
- Tel
- 029-86115547 17791676824
- Fax
- 02151602123
- sales@cochemical.com
- Country
- China
- ProdList
- 3014
- Advantage
- 58
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 42446
- Advantage
- 60
- Tel
- +86-2332782371 +86-18120098618
- sales@adobechem.com
- Country
- China
- ProdList
- 1250
- Advantage
- 50
- Tel
- 15618758386; 15618758386
- Fax
- QQ:3004479444
- sales3@myuchem.com
- Country
- China
- ProdList
- 1999
- Advantage
- 55
- Tel
- 17317567081
- info@coreuni.com
- Country
- China
- ProdList
- 201
- Advantage
- 55
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 2332782371
- Fax
- QQ: 2332782371
- adobechem@qq.com
- Country
- China
- ProdList
- 7980
- Advantage
- 58
- Tel
- 025-58851090 15955137747
- Fax
- (6)02557626880
- sales01@aikonchem.com
- Country
- China
- ProdList
- 15949
- Advantage
- 58
- Tel
- 021-61469567 13482353728
- Fax
- 021-61161605
- sales@fdc-chemical.com
- Country
- China
- ProdList
- 8840
- Advantage
- 58
View Lastest Price from 6-Bromo-8-fluoro-3,4-dihydroisoquinolin-1(2H)-one manufacturers
- Product
- 6-Bromo-8-fluoro-3,4-dihydroisoquinolin-1(2H)-one 1242157-15-8
- Price
- US $180.00-629.00/g
- Min. Order
- 1g
- Purity
- 0.99
- Supply Ability
- 1kg
- Release date
- 2024-04-12