3-IODO-IMIDAZO[1,2-A]PYRIDINE
- Product Name
- 3-IODO-IMIDAZO[1,2-A]PYRIDINE
- CAS No.
- 307503-19-1
- Chemical Name
- 3-IODO-IMIDAZO[1,2-A]PYRIDINE
- Synonyms
- 3-IODO-IMIDAZO[1,2-A]PYRIDINE;3-Iodoimidazolo[1,2-a]pyridine;IMIDAZO[1,2-A]PYRIDINE, 3-IODO-;3-Iodoimidazo[1,2-a]pyridine 97%;3-Iodoimidazo[1,2-a]pyridine 95+%
- CBNumber
- CB1305731
- Molecular Formula
- C7H5IN2
- Formula Weight
- 244.03
- MOL File
- 307503-19-1.mol
3-IODO-IMIDAZO[1,2-A]PYRIDINE Property
- Melting point:
- 165-170°C
- Density
- 2.01±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- solid
- pka
- 4.15±0.50(Predicted)
- Appearance
- Light yellow to brown Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 766836
- Product name
- 3-Iodoimidazo[1,2-a]pyridine
- Purity
- 97%
- Packaging
- 1g
- Price
- $217
- Updated
- 2022/05/15
- Product number
- I737093
- Product name
- 3-Iodoimidazo[1,2-a]pyridine
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- I737093
- Product name
- 3-Iodoimidazo[1,2-a]pyridine
- Packaging
- 250mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 066672
- Product name
- 3-Iodoimidazo[1,2-a]pyridine
- Packaging
- 1g
- Price
- $219
- Updated
- 2021/12/16
- Product number
- OR305157
- Product name
- 3-Iodoimidazo[1,2-a]pyridine
- Purity
- 95+%
- Packaging
- 1g
- Price
- $273
- Updated
- 2021/12/16
3-IODO-IMIDAZO[1,2-A]PYRIDINE Chemical Properties,Usage,Production
Synthesis
274-76-0
307503-19-1
Example 1 Synthesis of 3-iodoimidazo[1,2-a]pyridine In a 250 mL three-necked round-bottomed flask equipped with a magnetic stirrer, thermocouple, nitrogen inlet and outlet, and an ice bath cooling device, 11.61 g (98.27 mmol) of imidazo[1,2-a]pyridine was added to a 100 mL acetonitrile solution. At 0 °C, 24.32 g (108.1 mmol, 1.1 eq.) of N-iodosuccinimide solid was added in batches and the reaction mixture gradually changed to a yellow suspension. The reaction system was then slowly warmed to room temperature and stirred overnight. Upon completion of the reaction, the solvent was removed by rotary evaporation to give 39.2 g of dark solid crude product. The crude product was dissolved in 0.5 L of dichloromethane and washed sequentially with 10% aqueous KOH (2 x 250 mL) and water (200 mL). The organic phase was separated and dried with anhydrous Na2SO4. After filtration, the solvent was removed by rotary evaporation to give a dark colored residue. The residue was dissolved in boiling ethyl acetate and recrystallized by adding hexane. The precipitated white solid was collected by filtration, washed with 40 mL of hexane and dried under a stream of nitrogen to constant weight to give 20.8 g (86% yield) of the target product 3-iodoimidazo[1,2-a]pyridine. The product characterization data were as follows: - Rf = 0.42 (Expander: EtOAc/hexane = 1:1) - 1H NMR (CDCl3, δ): 8.12 (d, 1H, J = 6.8 Hz), 7.69 (s, 1H), 7.62 (d, 1H, J = 6.8 Hz), 7.24 (t, 1H, J = 6.8 Hz), 6.94 (t, 1H, J = 6.8 Hz) - 13C NMR (CDCl3, δ): 147.52, 140.02, 126.08, 125.23, 117.76, 113.43, 60.91 - LC-MS (ESI): m/z 245 [M+H]+ (C7H5N2I)
References
[1] Journal of Organic Chemistry, 2000, vol. 65, # 20, p. 6572 - 6575
[2] Patent: WO2010/33978, 2010, A2. Location in patent: Page/Page column 26-27
[3] Patent: CN103420977, 2016, B. Location in patent: Paragraph 0241-0244
[4] Patent: CN104341425, 2018, B. Location in patent: Paragraph 0137; 0139; 0140; 0141
[5] Chemistry of Heterocyclic Compounds, 2018, vol. 54, # 5, p. 568 - 571
3-IODO-IMIDAZO[1,2-A]PYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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