ChemicalBook > CAS DataBase List > Azido-PEG6-CH2CO2t-butyl ester

Azido-PEG6-CH2CO2t-butyl ester

Product Name: Azido-PEG6-CH2CO2t-butyl ester
CAS No.: 297162-49-3
Chemical Name: Azido-PEG6-CH2CO2t-butyl ester
Synonyms: N3-PEG6-COOtBu;Azido-PEG6-C1-Boc;N3-PEG6-CH2COOtBu;AZIDO-PEG6-CH2CO2TBU;Azido-PEG6-CH2COOtBu;Azido-PEG6-CH2COOH t-Bu Ester;Azido-PEG6-CH2CO2t-butyl ester;tert-Butyl 20-azido-3,6,9,12,15,18-hexaoxaic osanoate;N3-PEG6-CH2COOtBu/3,6,9,12,15,18-Hexaoxaeicosanoic acid, 20-azido-, 1,1-dimethylethyl ester
CBNumber: CB13062367
Molecular Formula: C18H35N3O8
Formula Weight: 421.49
MOL File: 297162-49-3.mol

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Apolloscientific

Product number: BIPG1151
Product name: Azido-PEG6-CH2CO2t-butyl ester
Packaging: 250mg
Price: $662
Updated: 2021/12/16

Activate Scientific

Product number: AS104044
Product name: N3-PEG6-CH2COOtBu
Purity: 95+%
Packaging: 1g
Price: $730
Updated: 2021/12/16

BroadPharm

Product number: BP-22132
Product name: Azido-PEG6-CH2CO2-t-Bu
Purity: 98%
Packaging: 1g
Price: $1200
Updated: 2021/12/16

Acrotein

Product number: B-0923
Product name: N3-PEG6-CH2COOtBu
Purity: 97%
Packaging: 0.5g
Price: $385
Updated: 2021/12/16

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Azido-PEG6-CH2CO2t-butyl ester Chemical Properties,Usage,Production

Description

Azido-PEG6-CH2CO2-t-Bu contain an azide group and a t-butyl ester. PEG spacer increases reagent's solubility in aqueous media. The azide (N3) group can react with alkyne, BCN, DBCO via Click Chemistry. The t-butyl protected carboxyl group can be deprotected under acidic condition.

Uses

Azido-PEG6-C1-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG6-C1-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Azido-PEG6-CH2CO2t-butyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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297162-49-3, Azido-PEG6-CH2CO2t-butyl esterRelated Search:

Azido-PEG6-CH2CO2t-butyl ester

AZIDO-PEG6-CH2CO2TBU

N3-PEG6-CH2COOtBu

Azido-PEG6-C1-Boc

Azido-PEG6-CH2COOtBu

Azido-PEG6-CH2COOH t-Bu Ester

N3-PEG6-CH2COOtBu/3,6,9,12,15,18-Hexaoxaeicosanoic acid, 20-azido-, 1,1-dimethylethyl ester

N3-PEG6-COOtBu

tert-Butyl 20-azido-3,6,9,12,15,18-hexaoxaic osanoate

297162-49-3

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